{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:16:00Z","timestamp":1765268160261},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. bras. pneumol."],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>OBJETIVO: Investigar o significado de marcadores de imunidade celular e de componentes el\u00e1sticos\/col\u00e1geno da matriz extracelular em estruturas granulomatosas em bi\u00f3psias de pacientes com sarcoidose pulmonar ou extrapulmonar. M\u00c9TODOS: Determina\u00e7\u00f5es qualitativas e quantitativas de c\u00e9lulas inflamat\u00f3rias, de fibras de col\u00e1geno e de fibras el\u00e1sticas em estruturas granulomatosas em bi\u00f3psias cir\u00fargicas de 40 pacientes com sarcoidose pulmonar e extrapulmonar foram realizadas por histomorfometria, imuno-histoqu\u00edmica, e t\u00e9cnicas de colora\u00e7\u00e3o com picrosirius e resorcina-fucsina de Weigert. RESULTADOS: A densidade de linf\u00f3citos, macr\u00f3fagos e neutr\u00f3filos nas bi\u00f3psias extrapulmonares foi significativamente maior do que nas bi\u00f3psias pulmonares. Os granulomas pulmonares apresentaram uma quantidade significativamente maior de fibras de col\u00e1geno e menor densidade de fibras el\u00e1sticas que os granulomas extrapulmonares. A quantidade de macr\u00f3fagos nos granulomas pulmonares correlacionou-se com CVF (p &lt; 0,05), ao passo que as quantidades de linf\u00f3citos CD3+, CD4+ e CD8+ correlacionaram-se com a rela\u00e7\u00e3o VEF1\/CVF e com CV. Houve correla\u00e7\u00f5es negativas entre CPT e contagem de c\u00e9lulas CD1a+ (p &lt; 0,05) e entre DLCO e densidade de fibras col\u00e1genas\/el\u00e1sticas (r = -0,90; p = 0,04). CONCLUS\u00d5ES: A imunofenotipagem e o remodelamento apresentaram caracter\u00edsticas diferentes nas bi\u00f3psias dos pacientes com sarcoidose pulmonar e extrapulmonar. Essas diferen\u00e7as correlacionaram-se com os dados cl\u00ednicos e espirom\u00e9tricos dos pacientes, sugerindo que h\u00e1 duas vias envolvidas no mecanismo de depura\u00e7\u00e3o de ant\u00edgenos, que foi mais eficaz nos pulm\u00f5es e linfonodos.<\/jats:p>","DOI":"10.1590\/s1806-37132012000300007","type":"journal-article","created":{"date-parts":[[2012,7,7]],"date-time":"2012-07-07T08:38:43Z","timestamp":1341650323000},"page":"321-330","source":"Crossref","is-referenced-by-count":5,"title":["Imunofenotipagem e remodelamento da matriz extracelular na sarcoidose pulmonar e extrapulmonar"],"prefix":"10.1590","volume":"38","author":[{"given":"Pedro Henrique Ramos Quintino da","family":"Silva","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin Roger","family":"Parra","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William Sanches","family":"Zocolaro","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivy","family":"Narde","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fab\u00edola","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronaldo Adib","family":"Kairalla","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Roberto Ribeiro de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, S\u00e3o Paulo, 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