{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:33:27Z","timestamp":1762659207741},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. bras. pneumol."],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>OBJETIVO: Investigar os efeitos da idade no enfisema pulmonar, com base nos valores do \u00edndice de enfisema (IE) em uma coorte de pacientes que nunca fumou e que n\u00e3o possu\u00eda doen\u00e7a pulmonar conhecida. M\u00c9TODOS: Foram revisados exames de TC, considerados normais, de 315 pacientes. Tabagismo, doen\u00e7as cardiorrespirat\u00f3rias e exposi\u00e7\u00e3o a drogas que poderiam causar doen\u00e7a pulmonar foram crit\u00e9rios de exclus\u00e3o. Dessa coorte, selecionamos 32 pacientes (16 homens e 16 mulheres), igualmente divididos em dois grupos (idade &lt; 50 anos e idade &gt; 50 anos), que foram pareados por g\u00eanero e \u00edndice de massa corp\u00f3rea. Realizou-se a quantifica\u00e7\u00e3o do enfisema utilizando um programa espec\u00edfico. O IE foi calculado com um limiar de -950 UH. O volume pulmonar total (VPT) e a densidade pulmonar m\u00e9dia (DPM) tamb\u00e9m foram avaliados. RESULTADOS: As m\u00e9dias gerais de VPT, DPM e IE foram 5.027 mL, -827 UH e 2,54%, respectivamente. A compara\u00e7\u00e3o entre os mais velhos e os mais novos mostrou as seguintes m\u00e9dias: VPT, 5.229 mL vs. 4.824 mL (p &gt; 0,05); DPM, -846 UH vs. -813 UH (p &lt; 0,04) e IE, 3,30% vs. 1,28% (p &lt; 0,001). Houve correla\u00e7\u00f5es significativas entre IE e idade (r = 0,66; p = 0,001), IE e VPT (r = 0,58; p = 0,001) e IE e DPM (r = -0,67; p &lt; 0,001). O IE previsto por idade foi definido atrav\u00e9s da equa\u00e7\u00e3o de regress\u00e3o (r\u00b2 = 0,43): p50(IE) = 0,049 \u00d7 idade - 0,5353. CONCLUS\u00d5ES: \u00c9 importante considerar a influ\u00eancia da idade na quantifica\u00e7\u00e3o de enfisema em pacientes com mais de 50 anos. Baseado na an\u00e1lise de regress\u00e3o, valores de IE de 2,6%, 3,5% e 4,5% podem ser considerados normais para pacientes com 30, 50 e 70 anos, respectivamente.<\/jats:p>","DOI":"10.1590\/s1806-37132012000400012","type":"journal-article","created":{"date-parts":[[2012,9,5]],"date-time":"2012-09-05T09:58:31Z","timestamp":1346839111000},"page":"494-502","source":"Crossref","is-referenced-by-count":5,"title":["\u00cdndice de enfisema pulmonar em coorte de pacientes sem doen\u00e7a pulmonar conhecida: influ\u00eancia da idade"],"prefix":"10.1590","volume":"38","author":[{"given":"Bruno","family":"Hochhegger","sequence":"first","affiliation":[{"name":"Hospital Moinhos de Vento; Santa Casa de Miseric\u00f3rdia de Porto Alegre,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giordano Rafael Tronco","family":"Alves","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus Loureiro","family":"Irion","sequence":"additional","affiliation":[{"name":"Liverpool Heart and Chest Hospital NHS Foundation Trust,  Reino Unido"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 da Silva","family":"Moreira","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de Porto Alegre,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edson dos Santos","family":"Marchiori","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"1","key":"ref1","first-page":"182","article-title":"The definition of emphysema: Report of a National Heart, Lung, and Blood Institute, Division of Lung Diseases workshop","volume":"132","year":"1985","journal-title":"Am Rev Respir Dis","ISSN":"http:\/\/id.crossref.org\/issn\/0003-0805","issn-type":"print"},{"issue":"5288","key":"ref2","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1126\/science.274.5288.740","article-title":"Evidence-based health policy: lessons from the Global Burden of Disease Study","volume":"274","author":"Murray CJ","year":"1996","journal-title":"Science","ISSN":"http:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1378\/chest.101.3.793","article-title":"The senile lung: Comparison with normal and emphysematous lungs. 1. 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Pneumologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/jbpneu\/v38n4\/v38n4a12.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T08:58:23Z","timestamp":1495875503000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1806-37132012000400012&lng=pt&tlng=pt"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S1806-37132012000400012"],"URL":"https:\/\/doi.org\/10.1590\/s1806-37132012000400012","relation":{},"ISSN":["1806-3713"],"issn-type":[{"value":"1806-3713","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}