{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:38:08Z","timestamp":1770482288211,"version":"3.49.0"},"reference-count":8,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. bras. pneumol."],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>A correla\u00e7\u00e3o entre a resist\u00eancia \u00e0 pirazinamida (PZA) e a resist\u00eancia a outros f\u00e1rmacos antituberculose de primeira linha foi investigada em 395 cepas de Mycobacterium tuberculosis provenientes de esp\u00e9cimes cl\u00ednicos, que representavam 14% do total de isolados de M. tuberculosis no per\u00edodo entre 2003 e 2008 no laborat\u00f3rio de um hospital universit\u00e1rio de refer\u00eancia para tuberculose. Uma alta correla\u00e7\u00e3o foi encontrada entre resist\u00eancia a PZA e multirresist\u00eancia, assim como entre resist\u00eancia a PZA e resist\u00eancia a rifampicina, isoniazida e etambutol (p &lt; 0,01 para todos). Esses resultados enfatizam a import\u00e2ncia da realiza\u00e7\u00e3o do teste de sensibilidade a PZA antes de prescrever a droga para o tratamento de tuberculose resistente e multirresistente.<\/jats:p>","DOI":"10.1590\/s1806-37132012000500013","type":"journal-article","created":{"date-parts":[[2012,11,10]],"date-time":"2012-11-10T10:58:32Z","timestamp":1352545112000},"page":"630-633","source":"Crossref","is-referenced-by-count":7,"title":["Correla\u00e7\u00e3o entre a resist\u00eancia a pirazinamida e a resist\u00eancia a outros f\u00e1rmacos antituberculose em cepas de Mycobacterium tuberculosis isoladas em um hospital de refer\u00eancia"],"prefix":"10.1590","volume":"38","author":[{"given":"Leila de Souza","family":"Fonseca","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Grazia","family":"Marsico","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisele Betzler de Oliveira","family":"Vieira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael da Silva","family":"Duarte","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Helena F\u00e9res","family":"Saad","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Instituto Oswaldo Cruz,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda de Carvalho Queiroz","family":"Mello","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"1","key":"ref1","first-page":"6","article-title":"The curious characteristics of pyrazinamide: a review","volume":"7","author":"Zhang Y","year":"2003","journal-title":"Int J Tuberc Lung Dis","ISSN":"https:\/\/id.crossref.org\/issn\/1027-3719","issn-type":"print"},{"key":"ref2","series-title":"Global tuberculosis control: a short update to the 2009 report"},{"key":"ref3","year":"2011"},{"key":"ref4","series-title":"Manual nacional de vigil\u00e2ncia laboratorial da tuberculose e outras micobact\u00e9rias","year":"2008"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/1471-2180-10-223","article-title":"Surveillance of pyrazinamide susceptibility among multidrug-resistant Mycobacterium tuberculosis isolates from Siriraj Hospital, Thailand","volume":"10","author":"Jonmalung J","year":"2010","journal-title":"BMC Microbiol"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1128\/JCM.00973-08","article-title":"Pyrazinamide resistance among South African multidrug-resistant Mycobacterium tuberculosis isolates","volume":"46","author":"Mphahlele M","year":"2008","journal-title":"J Clin Microbiol","ISSN":"https:\/\/id.crossref.org\/issn\/0095-1137","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/1471-2334-11-240","article-title":"Characteristics of pncA mutations in multidrug-resistant tuberculosis in Taiwan","volume":"11","author":"Chiu YC","year":"2011","journal-title":"BMC Infect Dis"},{"key":"ref8","series-title":"Guidelines for the programmatic management of drug-resistant tuberculosis, Emergency update 2008","year":"2008"}],"container-title":["Jornal Brasileiro de Pneumologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/jbpneu\/v38n5\/v38n5a13.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T10:26:49Z","timestamp":1495880809000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1806-37132012000500013&lng=pt&tlng=pt"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S1806-37132012000500013"],"URL":"https:\/\/doi.org\/10.1590\/s1806-37132012000500013","relation":{},"ISSN":["1806-3713"],"issn-type":[{"value":"1806-3713","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}