{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T07:11:54Z","timestamp":1714806714793},"reference-count":44,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. bras. pneumol."],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>O transplante pulmonar consolidou-se como a melhor op\u00e7\u00e3o terap\u00eautica para diversas pneumopatias terminais. O baixo n\u00famero de doadores vi\u00e1veis ainda persiste como uma grande limita\u00e7\u00e3o ao aumento do n\u00famero de transplantes de pulm\u00e3o, causando alta mortalidade na lista de espera. Diferentemente do transplante de outros \u00f3rg\u00e3os s\u00f3lidos, a maior limita\u00e7\u00e3o do transplante pulmonar n\u00e3o \u00e9 o n\u00famero absoluto de doadores e sim a viabilidade desses \u00f3rg\u00e3os, que \u00e9 reduzida devido \u00e0s agress\u00f5es ao pulm\u00e3o ocasionadas pela morte encef\u00e1lica e aos cuidados na UTI. Diversas s\u00e3o as propostas para o aumento do n\u00famero de doadores: intensifica\u00e7\u00e3o das campanhas de doa\u00e7\u00e3o, o uso de doadores com cora\u00e7\u00e3o parado, transplante pulmonar lobar intervivos e maior flexibilidade dos crit\u00e9rios para aceita\u00e7\u00e3o de doadores de pulm\u00e3o. Todavia, a proposta que atrai a aten\u00e7\u00e3o de diversos grupos de transplante pulmonar \u00e9 a perfus\u00e3o pulmonar ex vivo, principalmente pela perspectiva de recupera\u00e7\u00e3o de pulm\u00f5es inicialmente descartados. Esse sistema consiste na reperfus\u00e3o e ventila\u00e7\u00e3o do bloco pulmonar isolado em um circuito de circula\u00e7\u00e3o extracorp\u00f3rea modificado. Devido aos bons resultados apresentados e \u00e0 perspectiva de aumento no n\u00famero de \u00f3rg\u00e3os aptos a transplante, diversos grupos t\u00eam estudado a t\u00e9cnica. Pesquisadores na Su\u00e9cia, Canad\u00e1, \u00c1ustria, Inglaterra, Espanha e Brasil j\u00e1 possuem experi\u00eancia s\u00f3lida com o m\u00e9todo e introduziram algumas varia\u00e7\u00f5es. O objetivo deste artigo foi revisar o desenvolvimento, o estado da arte e as perspectivas futuras do modelo ex vivo de perfus\u00e3o e recondicionamento pulmonar.<\/jats:p>","DOI":"10.1590\/s1806-37132012000600015","type":"journal-article","created":{"date-parts":[[2013,1,3]],"date-time":"2013-01-03T08:35:15Z","timestamp":1357202115000},"page":"776-785","source":"Crossref","is-referenced-by-count":5,"title":["Recondicionamento pulmonar ex vivo: uma nova era para o transplante pulmonar"],"prefix":"10.1590","volume":"38","author":[{"given":"Alessandro Wasum","family":"Mariani","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Manuel","family":"P\u00eago-Fernandes","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis 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