{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T10:46:20Z","timestamp":1775645180240,"version":"3.50.1"},"reference-count":14,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. bras. pneumol."],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>ABSTRACT Objective: The halo sign consists of an area of ground-glass opacity surrounding pulmonary lesions on chest CT scans. We compared immunocompetent and immunosuppressed patients in terms of halo sign features and sought to identify those of greatest diagnostic value. Methods: This was a retrospective study of CT scans performed at any of seven centers between January of 2011 and May of 2015. Patients were classified according to their immune status. Two thoracic radiologists reviewed the scans in order to determine the number of lesions, as well as their distribution, size, and contour, together with halo thickness and any other associated findings. Results: Of the 85 patients evaluated, 53 were immunocompetent and 32 were immunosuppressed. Of the 53 immunocompetent patients, 34 (64%) were diagnosed with primary neoplasm. Of the 32 immunosuppressed patients, 25 (78%) were diagnosed with aspergillosis. Multiple and randomly distributed lesions were more common in the immunosuppressed patients than in the immunocompetent patients (p &lt; 0.001 for both). Halo thickness was found to be greater in the immunosuppressed patients (p &lt; 0.05). Conclusions: Etiologies of the halo sign differ markedly between immunocompetent and immunosuppressed patients. Although thicker halos are more likely to occur in patients with infectious diseases, the number and distribution of lesions should also be taken into account when evaluating patients presenting with the halo sign.<\/jats:p>","DOI":"10.1590\/s1806-37562015000000029","type":"journal-article","created":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T21:38:01Z","timestamp":1483825081000},"page":"435-439","source":"Crossref","is-referenced-by-count":21,"title":["The halo sign: HRCT findings in 85 patients"],"prefix":"10.1590","volume":"42","author":[{"given":"Giordano Rafael Tronco","family":"Alves","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Universidade Federal do Rio de Janeiro, Brazil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edson","family":"Marchiori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Irion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Schuler","family":"Nin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme","family":"Watte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro Comar\u00fa","family":"Pasqualotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Carlos","family":"Severo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Hochhegger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Liverpool Heart and Chest Hospital, United Kingdom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre, Brazil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"3","key":"ref1","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1148\/radiol.2462070712","article-title":"Fleischner Society glossary of terms for thoracic imaging","volume":"246","author":"Hansell DM","year":"2008","journal-title":"Radiology"},{"issue":"3","key":"ref2","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1148\/radiology.157.3.3864189","article-title":"Invasive pulmonary aspergillosis in acute leukemia characteristic findings on CT, the CT halo sign, and the role of CT in early diagnosis","volume":"157","author":"Kuhlman JE","year":"1985","journal-title":"Radiology"},{"issue":"933","key":"ref3","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1259\/bjr\/77712845","article-title":"CT halo sign the spectrum of pulmonary diseases","volume":"78","author":"Lee YR","year":"2005","journal-title":"Br J Radiol"},{"issue":"4","key":"ref4","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1097\/00004728-199907000-00025","article-title":"Halo sign on high resolution CT findings in spectrum of pulmonary diseases with pathologic correlation","volume":"23","author":"Kim Y","year":"1999","journal-title":"J Comput Assist Tomogr"},{"issue":"7","key":"ref5","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/S1579-2129(08)60066-X","article-title":"The halo sign in computed tomography images differential diagnosis and correlation with pathology findings [Article in Spanish]. 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