{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:42:19Z","timestamp":1759963339112},"reference-count":32,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. bras. pneumol."],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>ABSTRACT  Objective:  To determine whether COPD severity correlates with sputum cell counts, atopy, and asthma.  Methods:  This was a cross-sectional study involving 37 patients with COPD and 22 healthy subjects with normal lung function (controls). Sputum cell counts were determined by microscopy after centrifugation of samples. Skin prick tests were performed, and serum cytokines were determined by ELISA.  Results:  Patients were stratified by bronchodilator response: a non-reversible airflow limitation (nonRAL) group comprised 24 patients showing no significant post-bronchodilator change in FEV1; and a partially reversible airflow limitation (partialRAL) group comprised 13 patients showing FEV1 reversibility (post-bronchodilator FEV1 increase \u2265 12%). The proportion of eosinophils in sputum was higher in the partialRAL group than in the nonRAL group (p &lt; 0.01), and there was an inverse correlation between the proportion of eosinophils and FEV1 (p &lt; 0.05). However, none of the patients had a history of asthma and skin prick test results did not differ between the two groups. In the patient sputum samples, neutrophils predominated. Serum levels of TNF, IL-6, IL-8, and RANTES (CCL5) were higher in patients than in controls (p &lt; 0.001) but did not differ between the two patient groups.  Conclusions:  COPD patients with partial FEV1 reversibility appear to have higher sputum eosinophil counts and greater airway hyperresponsiveness than do those with no FEV1 reversibility. However, we found that COPD severity did not correlate with atopy or with the cytokine profile.<\/jats:p>","DOI":"10.1590\/s1806-37562015000000122","type":"journal-article","created":{"date-parts":[[2016,9,3]],"date-time":"2016-09-03T20:59:00Z","timestamp":1472936340000},"page":"241-247","source":"Crossref","is-referenced-by-count":16,"title":["Inflammatory and immunological profiles in patients with COPD: relationship with FEV 1 reversibility"],"prefix":"10.1590","volume":"42","author":[{"given":"Cleriston Farias","family":"Queiroz","sequence":"first","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Carlos Moreira","family":"Lemos","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria de Lourdes Santana","family":"Bastos","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarida C\u00e9lia Lima Costa","family":"Neves","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aquiles Assun\u00e7\u00e3o","family":"Camelier","sequence":"additional","affiliation":[{"name":"Universidade do Estado da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e1lia Barbosa","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar Marcelino de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"6","key":"ref1","first-page":"1926","article-title":"Airway eosinophilia in chronic bronchitis during 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