{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T07:58:12Z","timestamp":1700553492570},"reference-count":22,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. bras. pneumol."],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>ABSTRACT  Objective: To determine the presence of staphylococcal superantigen-specific IgE antibodies and degree of IgE-mediated sensitization, as well as whether or not those are associated with the severity of asthma in adult patients.  Methods: This was a cross-sectional study involving outpatients with asthma under treatment at a tertiary care university hospital in the city of Rio de Janeiro, Brazil. Consecutive patients were divided into two groups according to the severity of asthma based on the Global Initiative for Asthma criteria: mild asthma (MA), comprising patients with mild intermittent or persistent asthma; and moderate or severe asthma (MSA). We determined the serum levels of staphylococcal toxin-specific IgE antibodies, comparing the results and performing a statistical analysis.  Results: The study included 142 patients: 72 in the MA group (median age = 46 years; 59 females) and 70 in the MSA group (median age = 56 years; 60 females). In the sample as a whole, 62 patients (43.7%) presented positive results for staphylococcal toxin-specific IgE antibodies: staphylococcal enterotoxin A (SEA), in 29 (20.4%); SEB, in 35 (24.6%); SEC, in 33 (23.2%); and toxic shock syndrome toxin (TSST), in 45 (31.7%). The mean serum levels of IgE antibodies to SEA, SEB, SEC, and TSST were 0.96 U\/L, 1.09 U\/L, 1.21 U\/L, and 1.18 U\/L, respectively. There were no statistically significant differences between the two groups in terms of the qualitative or quantitative results.  Conclusions: Serum IgE antibodies to SEA, SEB, SEC, and TSST were detected in 43.7% of the patients in our sample. However, neither the qualitative nor quantitative results showed a statistically significant association with the clinical severity of asthma.<\/jats:p>","DOI":"10.1590\/s1806-37562016000000010","type":"journal-article","created":{"date-parts":[[2016,10,29]],"date-time":"2016-10-29T20:39:22Z","timestamp":1477773562000},"page":"356-361","source":"Crossref","is-referenced-by-count":3,"title":["Staphylococcal superantigen-specific IgE antibodies: degree of sensitization and association with severity of asthma"],"prefix":"10.1590","volume":"42","author":[{"given":"Jos\u00e9","family":"Elabras Filho","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brazil; Universidade Federal do Rio de Janeiro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Carvalho de Queiroz","family":"Mello","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Lupi","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brazil; Universidade Federal do Estado do Rio de Janeiro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca Elena Rios Gomes","family":"Bica","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Angelo de Souza","family":"Papi","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfeu Tavares","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  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