{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T01:17:59Z","timestamp":1776734279919,"version":"3.51.2"},"reference-count":38,"publisher":"FapUNIFESP (SciELO)","issue":"6","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. bras. pneumol."],"abstract":"<jats:p>ABSTRACT Objective: To estimate the prevalence of latent Mycobacterium tuberculosis infection (LTBI) in renal transplant recipients and to assess sociodemographic, behavioral, and clinical associations with positive tuberculin skin test (TST) results. Methods: This was a cross-sectional study of patients aged \u2265 18 years who underwent renal transplantation at the Renal Transplant Center of the Federal University of Minas Gerais Hospital das Cl\u00ednicas, located in the city of Belo Horizonte, Brazil. We included renal transplant recipients who underwent the TST between January 2011 and July 2013. If the result of the first TST was negative, a second TST was administered. Bivariate and multivariate analyses using logistic regression were used to determine factors associated with positive TST results. Results: The sample included 216 patients. The prevalence of LTBI was 18.5%. In the multivariate analysis, history of contact with a tuberculosis case and preserved graft function (estimated glomerular filtration rate \u2265 60 mL\/min\/1.73 m2) were associated with positive TST results. TST induration increased by 5.8% from the first to the second test, which was considered significant (p = 0.012). Conclusions: The prevalence of LTBI was low in this sample of renal transplant recipients. The TST should be administered if renal graft function is preserved. A second TST should be administered if the first TST is negative.<\/jats:p>","DOI":"10.1590\/s1806-37562017000000367","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T19:49:56Z","timestamp":1549396196000},"page":"461-468","source":"Crossref","is-referenced-by-count":11,"title":["Prevalence of latent Mycobacterium tuberculosis infection in renal transplant recipients"],"prefix":"10.1590","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3884-9507","authenticated-orcid":false,"given":"M\u00f4nica Maria Moreira Delgado","family":"Maciel","sequence":"first","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brazil; Universidade Federal de Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4340-0659","authenticated-orcid":false,"given":"Maria das Gra\u00e7as","family":"Ceccato","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2575-6352","authenticated-orcid":false,"given":"W\u00e2nia da Silva","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3267-4985","authenticated-orcid":false,"given":"Pedro Daibert de","family":"Navarro","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8978-4512","authenticated-orcid":false,"given":"K\u00e1tia de Paula","family":"Farah","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7245-4472","authenticated-orcid":false,"given":"Silvana Spindola de","family":"Miranda","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2018,12]]},"reference":[{"issue":"4","key":"ref1","article-title":"Dimensionamento dos transplantes no Brasil e em cada estado (2009-2016)","volume":"XXII","year":"2016","journal-title":"Registro Brasileiro de Transplantes"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1086\/427692","article-title":"Mycobacterium tuberculosis infection in recipients of solid organ transplants","volume":"40","author":"Mu-oz P","year":"2005","journal-title":"Clin Infect Dis"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0002-9343(79)90240-7","article-title":"Tuberculosis in patients undergoing maintenance hemodialysis","volume":"67","author":"Lundin AP","year":"1979","journal-title":"Am J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1111\/j.1600-6143.2009.02894.x","article-title":"Mycobacterium tuberculosis in solid organ transplant recipients","volume":"9","author":"Subramanian A","year":"2009","journal-title":"Am J Transplant"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.transproceed.2006.03.029","article-title":"Mycobacterium tuberculosis infection in renal transplant recipients","volume":"38","author":"Ergun I","year":"2006","journal-title":"Transplant Proc"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/ndt\/gfh691","article-title":"Tuberculosis in renal transplant recipients on various immunosuppressive regimens","volume":"20","author":"Atasever A","year":"2005","journal-title":"Nephrol Dial Transplant"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1086\/514993","article-title":"Mycobacterium tuberculosis infection in solid-organ transplant recipients Impact and implications for management","volume":"27","author":"Singh N","year":"1998","journal-title":"Clin Infect Dis"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1086\/599035","article-title":"Tuberculosis after solid-organ transplant incidence, risk factors, and clinical characteristics in the RESITRA (Spanish Network of Infection in Transplantation) cohort","volume":"48","author":"Torre-Cisneros J","year":"2009","journal-title":"Clin Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/ajt.12100","article-title":"Mycobacterium tuberculosis infectious in solid organ transplantation","volume":"13","author":"Subramanian AK","year":"2013","journal-title":"Am J Transplant"},{"issue":"9","key":"ref10","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1097\/00007890-199705150-00015","article-title":"Clinical presentation and outcome of tuberculosis in kidney, liver, and heart transplant recipients in Spain Spanish Transplantation Infection Study Group, GESITRA","volume":"63","author":"Aguado JM","year":"1997","journal-title":"Transplantation"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1590\/S1806-37132013000200013","article-title":"Prevalence of latent tuberculosis infection and risk of infection in patients with chronic kidney disease undergoing hemodialysis in a referral center in Brazil","volume":"39","author":"Fonseca JC","year":"2013","journal-title":"J Bras Pneumol"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.transproceed.2009.01.075","article-title":"Tuberculosis in renal transplant recipients a Brazilian center registry","volume":"41","author":"Guida JP","year":"2009","journal-title":"Transplant Proc"},{"issue":"10","key":"ref13","first-page":"1018","article-title":"III Brazilian Thoracic Association Guidelines on tuberculosis","volume":"35","author":"Conde MB","year":"2009","journal-title":"J Bras Pneumol"},{"key":"ref14","series-title":"Guidelines on the management of latent tuberculosis infection","year":"2017"},{"issue":"3","key":"ref15","first-page":"546","article-title":"Interpretation of the tuberculin test [Article in Portuguese] Rev Saude","volume":"40","author":"Ruffino-Netto A","year":"2006","journal-title":"Publica"},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1176\/ajp.131.10.1121","article-title":"The CAGE questionnaire Validation of a new alcoholism instrument","volume":"131","author":"Mayfield D","year":"1974","journal-title":"Am J Psychiatry"},{"issue":"10","key":"ref17","first-page":"845","article-title":"Smoking cessation guidelines--2008","volume":"34","author":"Reichert J","year":"2008","journal-title":"J Bras Pneumol"},{"key":"ref18","series-title":"Obesity: preventing and managing the global epidemic. Report of a World Health Organization Consultation","year":"2000"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.2337\/diacare.26.2007.S5","article-title":"Report of the expert committee on the diagnosis and classification of diabetes mellitus","volume":"26","year":"2003","journal-title":"Diabetes Care"},{"key":"ref20","series-title":"Tratamento e acompanhamento do Diabetes Mellitus--Diretrizes da Sociedade Brasileira de Diabetes","first-page":"14","volume-title":"M\u00e9todos e crit\u00e9rios para o diagn\u00f3stico de Diabetes mellitus","year":"2007"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1097\/TP.0b013e3182301602","article-title":"Estimating glomerular filtration rate in kidney transplant recipients performance over time of four creatinine-based formulas","volume":"92","author":"Buron F","year":"2011","journal-title":"Transplantation"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"206","DOI":"10.5935\/0101-2800.20130033","article-title":"Preval\u00eancia de tuberculose em transplantados renais revis\u00e3o sistem\u00e1tica e meta-an\u00e1lise","volume":"35","author":"Reis-Santos B","year":"2013","journal-title":"J Bras Nefrol"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1183\/09031936.00072909","article-title":"Global lung health the colliding epidemics of tuberculosis, tobacco smoking, HIV and COPD","volume":"35","author":"Van Zyl Smit RN","year":"2010","journal-title":"Eur Respir J"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1001\/archinte.167.4.335","article-title":"The risk of tuberculosis from exposure to tobacco smoke a systematic review and meta-analysis","volume":"167","author":"Bates MN","year":"2007","journal-title":"Arch Intern Med"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"340","DOI":"10.7326\/0003-4819-146-5-200703060-00006","article-title":"Meta-analysis new tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research","volume":"146","author":"Menzies D","year":"2007","journal-title":"Ann Intern Med"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1016\/j.transproceed.2006.06.010","article-title":"Efficacy of isoniazid prophylaxis in renal allograft recipients","volume":"38","author":"Naqvi R","year":"2006","journal-title":"Transplant Proc"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"634","DOI":"10.4269\/ajtmh.2009.80.634","article-title":"Impact of diabetes mellitus on treatment outcomes of patients with active tuberculosis","volume":"80","author":"Dooley KE","year":"2009","journal-title":"Am J Trop Med Hyg"},{"issue":"9","key":"ref28","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/j.1432-2277.2008.00694.x","article-title":"Hepatitis C virus, an important risk factor for tuberculosis in immunocompromised experience with kidney transplantation","volume":"21","author":"Torres J","year":"2008","journal-title":"Transpl Int"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1093\/ndt\/gfp489","article-title":"Use of isoniazid chemoprophylaxis in renal transplant recipients","volume":"25","author":"Naqvi R","year":"2010","journal-title":"Nephrol Dial Transplant"},{"issue":"11","key":"ref30","first-page":"1192","article-title":"False-positive tuberculin skin tests what is the absolute effect of BCG and non-tuberculous mycobacteria?","volume":"10","author":"Farhat M","year":"2006","journal-title":"Int J Tuberc Lung Dis"},{"issue":"2","key":"ref31","first-page":"1","article-title":"Minist\u00e9rio da Sa\u00fade Informe eletr\u00f4nico da tuberculose","volume":"9","year":"2009","journal-title":"Boletim Eletr\u00f4nico Epidemiol\u00f3gico"},{"issue":"5","key":"ref32","first-page":"498","article-title":"Thinking in three dimensions a web-based algorithm to aid the interpretation of tuberculin skin test results","volume":"12","author":"Menzies D","year":"2008","journal-title":"Int J Tuberc Lung Dis"},{"issue":"7","key":"ref33","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/TP.0b013e3181ecea8d","article-title":"Tuberculosis in renal transplant recipients the evidence for prophylaxis","volume":"90","author":"Currie AC","year":"2010","journal-title":"Transplantation"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/ndt\/gfg569","article-title":"The value of tuberculin skin testing in haemodialysis patients","volume":"19","author":"Wauters A","year":"2004","journal-title":"Nephrol Dial Transplant"},{"issue":"11","key":"ref35","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1093\/ndt\/gfl416","article-title":"Improved efficiency in detecting cellular immunity towards M tuberculosis in patients receiving immunosuppressive drug therapy","volume":"21","author":"Sester U","year":"2006","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"ref36","first-page":"1","article-title":"Minist\u00e9rio da Sa\u00fade O controle da tuberculose no Brasil: avan\u00e7os, inova\u00e7\u00f5es e desafios","volume":"45","year":"2014","journal-title":"Boletim Epidemiol\u00f3gico"},{"key":"ref37","series-title":"Understanding Tuberculosis: global experiences and innovative approaches to the diagnosis","first-page":"395","volume-title":"Exosomes: New Tuberculosis Biomarkers - Prospects From the Bench to the Clinic","author":"Kruh-Garcia NA","year":"2012"},{"issue":"9729","key":"ref38","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1016\/S0140-6736(10)60359-5","article-title":"Biomarkers and diagnostics for tuberculosis progress, needs, and translation into practice","volume":"375","author":"Wallis R","year":"2010","journal-title":"Lancet"}],"container-title":["Jornal Brasileiro de Pneumologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/jbpneu\/v44n6\/1806-3713-jbpneu-44-06-00461.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T11:59:31Z","timestamp":1694606371000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1806-37132018000600461&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":38,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["S1806-37132018000600461"],"URL":"https:\/\/doi.org\/10.1590\/s1806-37562017000000367","relation":{},"ISSN":["1806-3756","1806-3713"],"issn-type":[{"value":"1806-3756","type":"electronic"},{"value":"1806-3713","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]}}}