{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T09:59:15Z","timestamp":1770544755202,"version":"3.49.0"},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","issue":"6","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. bras. pneumol."],"abstract":"<jats:p>ABSTRACT  Objective: To conduct a longitudinal investigation of cardiac vagal activity (CVA) by measuring resting HR and calculating the cardiac vagal index (CVI) in individuals undergoing sympathectomy for the treatment of primary hyperhidrosis.  Methods: This was a descriptive longitudinal study involving 22 patients, 13 of whom were female. The mean age was 22.5 \u00b1 8.8 years. The palms, soles, and axillae were the most commonly affected sites. Resting HR was measured by an electrocardiogram performed 20 min before the 4-second exercise test (4sET), which was used in order to evaluate CVA at three different time points: before surgery, one month after surgery, and four years after surgery.  Results: Resting HR (expressed as mean \u00b1 SE) was found to have decreased significantly at 1 month after surgery (73.1 \u00b1 1.6 bpm before surgery vs. 69.7 \u00b1 1.2 bpm at one month after surgery; p = 0.01). However, the HR values obtained at four years after surgery tended to be similar to those obtained before surgery (p = 0.31). The CVI (expressed as mean \u00b1 SE) was found to have increased significantly at one month after surgery (1.44 \u00b1 0.04 before surgery vs. 1.53 \u00b1 0.03 at one month after surgery; p = 0.02). However, the CVI obtained at four years after surgery tended to be similar to that obtained before surgery (p = 0.10).  Conclusions: At one month after sympathectomy for primary hyperhidrosis, patients present with changes in resting HR and CVA, both of which tend to return to baseline at four years after surgery.<\/jats:p>","DOI":"10.1590\/s1806-37562017000000464","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T15:08:04Z","timestamp":1549379284000},"page":"456-460","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal follow-up of cardiac vagal activity in individuals undergoing endoscopic thoracic sympathectomy"],"prefix":"10.1590","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5761-798X","authenticated-orcid":false,"given":"Ana Paula","family":"Ferreira","sequence":"first","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro,  Brazil; Faculdade de Ci\u00eancias M\u00e9dicas e da Sa\u00fade de Juiz de Fora,  Brazil; Hospital e Maternidade Therezinha de Jesus,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4035-3890","authenticated-orcid":false,"given":"Plinio dos Santos","family":"Ramos","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro,  Brazil; Faculdade de Ci\u00eancias M\u00e9dicas e da Sa\u00fade de Juiz de Fora,  Brazil; Hospital e Maternidade Therezinha de Jesus,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0143-8384","authenticated-orcid":false,"given":"Jorge","family":"Montessi","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas e da Sa\u00fade de Juiz de Fora,  Brazil; Hospital e Maternidade Therezinha de Jesus,  Brasil; Hospital Monte Sinai,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7736-3094","authenticated-orcid":false,"given":"Fl\u00e1via Duarte","family":"Montessi","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas e da Sa\u00fade de Juiz de Fora,  Brazil; Hospital e Maternidade Therezinha de Jesus,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4973-2398","authenticated-orcid":false,"given":"Eveline Montessi","family":"Nicolini","sequence":"additional","affiliation":[{"name":"Hospital e Maternidade Therezinha de Jesus,  Brasil; Hospital Monte Sinai,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5510-0015","authenticated-orcid":false,"given":"Edmilton Pereira de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Hospital Monte Sinai,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2456-1470","authenticated-orcid":false,"given":"Djalma Rabelo","family":"Ricardo","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro,  Brazil; Faculdade de Ci\u00eancias M\u00e9dicas e da Sa\u00fade de Juiz de Fora,  Brazil; Hospital e Maternidade Therezinha de Jesus,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2018,12]]},"reference":[{"key":"ref1","article-title":"Hyperhidrosis medical and surgical treatment","volume":"8","author":"Stolman LP","year":"2008","journal-title":"Eplasty"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0733-8635(05)70062-0","article-title":"Treatment of hyperhidrosis","volume":"16","author":"Stolman LP","year":"1998","journal-title":"Dermatol Clin"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1067\/mtc.2002.119340","article-title":"Anatomic variations of the T2 nerve root (including the nerve of Kuntz) and their implications for sympathectomy","volume":"123","author":"Chung IH","year":"2002","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"3","key":"ref4","first-page":"248","article-title":"Video-assisted thoracic sympathectomy in the treatment of primary hyperhidrosis a retrospective study of 521 cases comparing different levels of ablation","volume":"33","author":"Montessi J","year":"2007","journal-title":"J Bras Pneumol"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1378\/chest.20.2.139","article-title":"The endoscopic approach to the vegetative nervous system and its therapeutic possibilities; especially in duodenal ulcer, angina pectoris, hypertension and diabetes","volume":"20","author":"KUX E","year":"1951","journal-title":"Dis Chest"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.5688\/aj710478","article-title":"Physiology of the autonomic nervous system","volume":"71","author":"McCorry LK","year":"2007","journal-title":"Am J Pharm Educ"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1152\/advan.00004.2010","article-title":"Case studies in a physiology course on the autonomic nervous system design, implementation, and evaluation","volume":"34","author":"Zimmermann M","year":"2010","journal-title":"Adv Physiol Educ"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s007010070114","article-title":"Endoscopic transthoracic sympathicotomy affects the autonomic modulation of heart rate in patients with palmar hyperhidrosis","volume":"142","author":"Wiklund U","year":"2000","journal-title":"Acta Neurochir (Wien)"},{"issue":"8942","key":"ref9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0140-6736(95)90065-9","article-title":"Endoscopic transthoracic sympathicotomy for severe angina","volume":"345","author":"Wettervik MD","year":"1995","journal-title":"Lancet"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0165-1838(96)00034-3","article-title":"Changes in cardiocirculatory autonomic function after thoracoscopic upper dorsal sympathicolysis for essential hyperhidrosis","volume":"60","author":"Noppen M","year":"1996","journal-title":"J Auton Nerv Syst"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/S0003-4975(02)04080-8","article-title":"Holter changes resulting from right-sided and bilateral infrastellate upper thoracic sympathectomy","volume":"74","author":"Abraham P","year":"2002","journal-title":"Ann Thorac Surg"},{"issue":"18","key":"ref12","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1056\/NEJM199910283411804","article-title":"Heart-rate recovery immediately after exercise as a predictor of mortality","volume":"341","author":"Cole CR","year":"1999","journal-title":"N Engl J Med"},{"issue":"8","key":"ref13","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1161\/01.CIR.0000027565.12764.E1","article-title":"Exercise-induced increase in baroreflex sensitivity predicts improved prognosis after myocardial infarction","volume":"106","author":"La Rovere MT","year":"2002","journal-title":"Circulation"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.biopsycho.2005.11.013","article-title":"The role of vagal function in the risk for cardiovascular disease and mortality","volume":"74","author":"Thayer JF","year":"2007","journal-title":"Biol Psychol"},{"key":"ref15","first-page":"1","article-title":"VI Brazilian Guidelines on Hypertension [Article in Portuguese]","volume":"95","year":"2010","journal-title":"Arq Bras Cardiol"},{"issue":"5","key":"ref16","first-page":"293","article-title":"Intra and interdays reliability of the 4-second exercise test","volume":"9","author":"Ara\u00fajo CGS","year":"2003","journal-title":"Rev Bras Med Esporte"},{"issue":"6","key":"ref17","first-page":"493","article-title":"Comparison of assessment methods of cardiac vagal modulation","volume":"97","author":"Paiva VC","year":"2011","journal-title":"Arq Bras Cardiol"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF01824209","article-title":"Heart rate responses to deep breathing and 4-seconds of exercise before and after pharmacological blockade with atropine and propranolol","volume":"2","author":"Araujo CG","year":"1992","journal-title":"Clin Auton Res"},{"issue":"8","key":"ref19","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1007\/s00464-010-0885-5","article-title":"Endoscopic thoracic sympathectomy for primary palmar hyperhidrosis","volume":"24","author":"Prasad A","year":"2010","journal-title":"Surg Endosc"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3349\/ymj.2012.53.6.1081","article-title":"The effects of thoracic sympathotomy on heart rate variability in patients with palmar hyperhidrosis","volume":"53","author":"Zhang TY","year":"2012","journal-title":"Yonsei Med J"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S1010-7940(98)00309-1","article-title":"Influences of bilateral endoscopic transthoracic sympathicotomy on cardiac autonomic nervous activity","volume":"15","author":"Tedoriya T","year":"1999","journal-title":"Eur J Cardiothorac Surg"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.jtcvs.2008.07.021","article-title":"Effects of endoscopic thoracic sympathectomy for primary hyperhidrosis on cardiac autonomic nervous activity","volume":"137","author":"Cruz J","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10286-010-0080-8","article-title":"Autonomic function following endoscopic thoracic sympathotomy for hyperhidrosis","volume":"21","author":"Schmidt JE","year":"2011","journal-title":"Clin Auton Res"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10286-003-0104-8","article-title":"Blood pressure and heart rate variability in patients with essential hyperhidrosis","volume":"13","author":"Senard JM","year":"2003","journal-title":"Clin Auton Res"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.athoracsur.2016.10.055","article-title":"Cardiac Autonomic Changes After Thoracic Sympathectomy A Prospective, Randomized Study","volume":"103","author":"Fiorelli A","year":"2017","journal-title":"Ann Thorac Surg"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1161\/01.HYP.29.5.1119","article-title":"Baroreflex sensitivity assessed by complex demodulation of cardiovascular variability","volume":"29","author":"Kim SY","year":"1997","journal-title":"Hypertension"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ijcard.2004.09.013","article-title":"The reliability of short-term measurements of heart rate variability","volume":"103","author":"Sandercock GR","year":"2005","journal-title":"Int J Cardiol"},{"issue":"2","key":"ref28","first-page":"205","article-title":"Basic notions of heart rate variability and its clinical applicability","volume":"24","author":"Vanderlei LC","year":"2009","journal-title":"Rev Bras Cir Cardiovasc"}],"container-title":["Jornal Brasileiro de Pneumologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/jbpneu\/v44n6\/1806-3713-jbpneu-44-06-00456.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T12:34:42Z","timestamp":1579869282000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1806-37132018000600456&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":28,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["S1806-37132018000600456"],"URL":"https:\/\/doi.org\/10.1590\/s1806-37562017000000464","relation":{},"ISSN":["1806-3756","1806-3713"],"issn-type":[{"value":"1806-3756","type":"electronic"},{"value":"1806-3713","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]}}}