{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T16:09:44Z","timestamp":1696522184444},"reference-count":18,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. oral res."],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p>The aim of the present parallel, double-blind investigation was to evaluate the effect of using systemic metronidazole alone or associated to scaling and root planing on adult chronic periodontal disease, monitored at baseline, 30, 60 and 90 days. Twelve subjects were divided into three groups: the first group (Group I - 22 sites) was submitted to scaling and root planing (SRP) alone; the second group (Group II - 30 sites) received SRP and 250 mg of metronidazole (3 times a day for 10 days), and the third group (Group III - 31 sites) was treated with metronidazole alone. The clinical parameters evaluated were probing depth (PD), clinical attachment level (CAL), plaque index (PlI), gingival index (GI) and bleeding upon probing (BP). Microbiological (BANA test) and enzymatic (Pocket Watch) tests were also performed. All three proposed treatments produced significant improvements in clinical conditions of subjects, from baseline, 30, 60 and 90-day period, except for clinical attachment level. The results obtained by microbiological and enzymatic tests did not show statistical differences among the groups for the 90-day period (r = 0.7924 and r = 0.7757, respectively). In relation to clinical parameters, statistical differences among groups were observed only for the gingival index (p = 0.0261) between Groups I and II, and probing depth (p = 0.0124) between Group I and the others. We conclude that the use of systemic metronidazole did not produce additional effects on the microbiological conditions of these patients with chronic periodontal disease.<\/jats:p>","DOI":"10.1590\/s1806-83242004000200006","type":"journal-article","created":{"date-parts":[[2005,4,18]],"date-time":"2005-04-18T11:49:26Z","timestamp":1113824966000},"page":"121-127","source":"Crossref","is-referenced-by-count":9,"title":["Systemic use of metronidazole in the treatment of chronic periodontitis: a pilot study using clinical, microbiological, and enzymatic evaluation"],"prefix":"10.1590","volume":"18","author":[{"given":"Solange Alonso","family":"Vergani","sequence":"first","affiliation":[{"name":"S\u00e3o Paulo State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Em\u00edlio Barbosa e","family":"Silva","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Helena","family":"Vinholis","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary Adriana Chi\u00e9rici","family":"Marcantonio","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"28","article-title":"The effects of metronidazole on clinical and microbiologic parameters of periodontal disease","volume":"13","author":"Eisenberg L","year":"1991","journal-title":"Clin Prev Dent","ISSN":"http:\/\/id.crossref.org\/issn\/0163-9633","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1600-051X.1985.tb01357.x","article-title":"Effects of short-term administration of metronidazole on the subgingival microflora","volume":"12","author":"Giedrys-Leeper E","year":"1985","journal-title":"J Clin Periodontol","ISSN":"http:\/\/id.crossref.org\/issn\/0303-6979","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1600-051X.1988.tb01011.x","article-title":"Combined antibiotic (metronidazole) and mechanical treatment effects on the subgingival bacterial flora of sites with recurrent periodontal disease","volume":"15","author":"Gusberti FA","year":"1988","journal-title":"J Clin Periodontol","ISSN":"http:\/\/id.crossref.org\/issn\/0303-6979","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1902\/jop.1983.54.8.476","article-title":"The effect of metronidazole on human periodontal disease. 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I","volume":"55","author":"Loesche WJ","year":"1984","journal-title":"Clinical and bacteriological results after 15 to 30 weeks. 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II. 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