{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:47:06Z","timestamp":1790275626433,"version":"4.1.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,21]],"date-time":"2011-10-21T00:00:00Z","timestamp":1319155200000},"content-version":"vor","delay-in-days":293,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1590\/s1807-59322011000300023","type":"journal-article","created":{"date-parts":[[2011,5,5]],"date-time":"2011-05-05T11:29:26Z","timestamp":1304594966000},"page":"493-499","source":"Crossref","is-referenced-by-count":40,"title":["Atypical mole syndrome and dysplastic nevi: identification of populations at risk for developing melanoma - review article"],"prefix":"10.1016","volume":"66","author":[{"given":"Juliana Hyp\u00f3lito","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Costa Soares","family":"de S\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Leon Ribeiro","family":"de \u00c1vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Landman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Pedreira Duprat","family":"Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1590\/S1807-59322011000300023_bib1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0190-9622(93)70279-3","article-title":"How common is the atypical mole syndrome phenotype in apparently sporadic melanoma","volume":"29","author":"Newton","year":"1993","journal-title":"J Am Acad Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib2","first-page":"44","article-title":"Meta-analysis of risk factors for cutaneous melanoma: I. Common and atypical naevi","volume":"41","author":"Gandini","year":"2005","journal-title":"Eur J Cancer"},{"key":"10.1590\/S1807-59322011000300023_bib3","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/0190-9622(95)90073-X","article-title":"Atypical mole syndrome: Risk factor for cutaneous malignant melanoma and implications for management","volume":"32","author":"Slade","year":"1995","journal-title":"J Am Acad Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1056\/NEJMra052166","article-title":"Melanoma","volume":"355","author":"Miller","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1590\/S1807-59322011000300023_bib5","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0140-6736(05)17951-3","article-title":"Cutaneous Melanoma","volume":"365","author":"Thompson","year":"2005","journal-title":"Lancet"},{"key":"10.1590\/S1807-59322011000300023_bib6","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1200\/JCO.2009.23.4799","article-title":"Final Version of 2009 AJCC Melanoma Staging and Classification","volume":"27","author":"Balch","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1590\/S1807-59322011000300023_bib7","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1056\/NEJMra041245","article-title":"Management of Cutaneous Melanoma","volume":"351","author":"Tsao","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1590\/S1807-59322011000300023_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.clindermatol.2008.09.008","article-title":"The \u201cdysplastic\u201d nevus","volume":"27","author":"Friedman","year":"2009","journal-title":"Clin Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib9","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.clindermatol.2008.09.005","article-title":"Melanoma and genetics","volume":"27","author":"Nelson","year":"2009","journal-title":"Clin Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib10","first-page":"65","article-title":"Case of Fungoid Disease","volume":"16","author":"Norris","year":"1820","journal-title":"Edinburgh Medical and Surgical Journal"},{"key":"10.1590\/S1807-59322011000300023_bib11","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1001\/archderm.1978.01640170032006","article-title":"Origin of familial malignant melanomas from heritable melanocytic lesions. \u2018The B-K mole syndome\u2019","volume":"114","author":"Clark","year":"1978","journal-title":"Arch Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib12","first-page":"93","article-title":"Dermatoscopy of \u201cdysplastic nevi\u201d : A beacon in diagnostic darkness","volume":"16","author":"Roesch","year":"2006","journal-title":"Eur J Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3109\/00313028509063770","article-title":"The dysplastic nevus","volume":"17","author":"Elder","year":"1985","journal-title":"Pathology"},{"key":"10.1590\/S1807-59322011000300023_bib14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0046-8177(84)80310-X","article-title":"A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma","volume":"15","author":"Clark","year":"1984","journal-title":"Hum Pathol"},{"key":"10.1590\/S1807-59322011000300023_bib15","first-page":"3","article-title":"Risk gradient for malignant melanoma in individuals with dysplastic naevi","volume":"1","author":"Rigel","year":"1988","journal-title":"Lancet"},{"key":"10.1590\/S1807-59322011000300023_bib16","first-page":"7","article-title":"Dysplastic naevi and cutaneous melanoma risk","volume":"2","author":"Kraemer","year":"1983","journal-title":"Lancet"},{"key":"10.1590\/S1807-59322011000300023_bib17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/1097-0142(19941215)74:12<3118::AID-CNCR2820741210>3.0.CO;2-7","article-title":"Dysplastic Nevi as a Melanoma Risk Factor in Patients with Familial Melanona","volume":"74","author":"Carey","year":"1994","journal-title":"Cancer"},{"key":"10.1590\/S1807-59322011000300023_bib18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1056\/NEJMcp023017","article-title":"Dysplastic Nevi","volume":"349","author":"Naeyaert","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1590\/S1807-59322011000300023_bib19","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.det.2008.12.002","article-title":"Melanoma Epidemiology and Public Health","volume":"27","author":"Berwick","year":"2009","journal-title":"Dermatol Clin"},{"key":"10.1590\/S1807-59322011000300023_bib20","first-page":"4","article-title":"Genome-wide linkage scan for atypical nevi in p16-Leiden melanoma families","volume":"16","author":"de Snoo","year":"2008","journal-title":"Eur J Hum Genet"},{"key":"10.1590\/S1807-59322011000300023_bib21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0733-8635(18)30897-0","article-title":"Dysplastic nevus syndrome: familial and sporadic precursor of cutaneous melanoma","volume":"3","author":"Kraemer","year":"1985","journal-title":"Dermatol Clin"},{"key":"10.1590\/S1807-59322011000300023_bib22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1365-2230.2004.01656.x","article-title":"Evaluation of germline CDKN2A, ARF, CDK4, PTEN, and BRAF alterations in atypical mole syndrome","volume":"30","author":"Celebi","year":"2005","journal-title":"Clin Exp Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib23","first-page":"20","article-title":"Atypical (dysplastic) cell nevus: histopathology and historical aspects","volume":"23","author":"Landman","year":"2003","journal-title":"Acta oncol. Bras"},{"key":"10.1590\/S1807-59322011000300023_bib24","first-page":"94","article-title":"Gene-covariate interaction between dysplastic nevi and the CDKN2A gene in American melanoma-prone families","volume":"9","author":"Goldstein","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1590\/S1807-59322011000300023_bib25","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1158\/1055-9965.EPI-04-0777","article-title":"Melanocortin-1 receptor (MC1R) gene variants and dysplastic nevi modify penetrance of CDKN2A mutations in French melanoma-prone pedigrees","volume":"14","author":"Chaudru","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1590\/S1807-59322011000300023_bib26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1001\/archderm.139.12.1620","article-title":"Cutaneous melanomas associated with nevi","volume":"139","author":"Bevona","year":"2003","journal-title":"Arch Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0190-9622(93)70151-I","article-title":"Natural history of dysplastic nevi","volume":"29","author":"Halpern","year":"1993","journal-title":"J Am Acad Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib28","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0190-9622(08)80006-0","article-title":"Atypical mole syndrome","volume":"22","author":"Kopf","year":"1990","journal-title":"J Am Acad Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib29","first-page":"9","article-title":"Diagnosis and treatment of early melanoma","volume":"268","year":"1992","journal-title":"JAMA"},{"key":"10.1590\/S1807-59322011000300023_bib30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/1097-0142(19890115)63:2<386::AID-CNCR2820630231>3.0.CO;2-6","article-title":"Dysplastic nevi: markers for increased risk for melanoma","volume":"63","author":"Rigel","year":"1989","journal-title":"Cancer"},{"key":"10.1590\/S1807-59322011000300023_bib31","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1136\/jmg.15.5.352","article-title":"Familial atypical multiple mole-melanoma syndrome","volume":"15","author":"Lynch","year":"1978","journal-title":"J Med Genet"},{"key":"10.1590\/S1807-59322011000300023_bib32","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/jid.1993.62","article-title":"The risk of melanoma and other cancers in melanoma-prone families","volume":"100","author":"Tucker","year":"1993","journal-title":"J Invest Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib33","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.hoc.2009.03.001","article-title":"Melanoma Early Detection","volume":"23","author":"Terushkin","year":"2009","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1590\/S1807-59322011000300023_bib34","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1067\/mjd.2000.107504","article-title":"Follow-up of melanocytic skin lesions with digital epiluminescence microscopy: patterns of modifications observed in early melanoma, atypical nevi, and common nevi","volume":"43","author":"Kittler","year":"2000","journal-title":"J Am Acad Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jaad.2003.09.009","article-title":"Addition of dermoscopy to conventional naked-eye examination in melanoma screening: a randomized study","volume":"50","author":"Carli","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib36","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jaad.2007.01.014","article-title":"Sensitivity, specificity, and diagnostic accuracy of three dermoscopic algorithmic methods in the diagnosis ofdoubtful melanocytic lesions: the importance of light brown structureless areas in differentiating atypical melanocytic nevi from thim melanomas","volume":"56","author":"Annessi","year":"2007","journal-title":"J Am Acad Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib37","series-title":"Manual de Dermatoscop\u00eda.","first-page":"45","article-title":"Lesiones Melanoc\u00edticas","author":"Malvehy","year":"2006"},{"key":"10.1590\/S1807-59322011000300023_bib38","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1590\/S0365-05962006000300009","article-title":"Dermatoscopia: o m\u00e9todo de an\u00e1lise de padr\u00f5es","volume":"81","author":"Rezze","year":"2006","journal-title":"An Bras Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib39","series-title":"Atlas de Dermatoscopia Aplicada","first-page":"103","article-title":"Dermatoscopia dos Nevos At\u00edpicos","author":"Soares de S\u00e1","year":"2009"},{"key":"10.1590\/S1807-59322011000300023_bib40","first-page":"12","article-title":"Pigmented lesions clinic for early detection of melanoma: preliminary results","volume":"9","author":"Nathansohn","year":"2007","journal-title":"Isr Med Assoc J"},{"key":"10.1590\/S1807-59322011000300023_bib41","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1159\/000096904","article-title":"Dermoscopy key points: recommendations from the international dermoscopy society","volume":"214","author":"Bowling","year":"2007","journal-title":"Dermatology"},{"key":"10.1590\/S1807-59322011000300023_bib42","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00008469-200404000-00007","article-title":"Results of a surveillance programme for patients at high risk of malignant melanoma using digital and conventional dermoscopy","volume":"13","author":"Haenssle","year":"2004","journal-title":"Eur J Cancer Prev"},{"key":"10.1590\/S1807-59322011000300023_bib43","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1067\/mjd.2003.283","article-title":"Early melanoma detection:nonuniform dermoscopic features ad growth","volume":"48","author":"Lucas","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib44","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1001\/archderm.141.8.998","article-title":"Incidence of new and changed nevi and melanomas detected using baseline images and dermoscopy in patients with high risk for melanoma","volume":"141","author":"Banky","year":"2005","journal-title":"Arch Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib45","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1529-8019.2005.00054.x","article-title":"Cutaneous melanoma: making a clinical diagnosis, present and future","volume":"19","author":"Menzies","year":"2006","journal-title":"Dermatol Ther"},{"key":"10.1590\/S1807-59322011000300023_bib46","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1001\/archderm.137.12.1583","article-title":"Short-term digital surface microscopic monitoring of atypical or changing melanocytic lesions","volume":"137","author":"Menzies","year":"2001","journal-title":"Arch Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib47","first-page":"48","article-title":"Final Version of the American Joint Committee on Cancer Staging System for Cutaneous Melanoma","volume":"19","author":"Balch","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1590\/S1807-59322011000300023_bib48","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0190-9622(86)70100-X","article-title":"Importance of complete cutaneous examination for the detection of malignant melanoma","volume":"14","author":"Rigel","year":"1986","journal-title":"J Am Acad Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib49","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0190-9622(87)70239-4","article-title":"In vivo epiluminescence microscopy of pigmented skin lesions: I. pattern analysis of pigmented skin lesions","volume":"17","author":"Pehamberger","year":"1987","journal-title":"J Am Acad Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib50","first-page":"91","article-title":"In vivo epiluminescence microscopy of pigmented skin lesions: II","volume":"17","author":"Steiner","year":"1987","journal-title":"Diagnosis of small pigmented skin lesions and early detection of malignant melanoma. J Am Acad Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib51","series-title":"Atlas de Dermatoscopia Aplicada","first-page":"17","article-title":"Hist\u00f3rio e Fundamentos da Dermatoscopia","year":"2009"},{"key":"10.1590\/S1807-59322011000300023_bib52","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1001\/archderm.136.7.915","article-title":"Laser treatment of pigmented lesions - 2000: how far have we gone","volume":"136","author":"Stratigos","year":"2000","journal-title":"Arch Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib53","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0161-6420(86)33684-4","article-title":"Ocular findings in patients with dysplastic nevus syndrome","volume":"93","author":"Rodriguez-Sains","year":"1986","journal-title":"Ophthalmology"},{"key":"10.1590\/S1807-59322011000300023_bib54","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/0190-9622(90)70304-Z","article-title":"Ocular melanoma in families with dysplastic nevus syndrome","volume":"23","author":"Vink","year":"1990","journal-title":"J Am Acad Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib55","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/bmj.288.6411.99","article-title":"Pigmentation and skin reaction to sun as risk factors for cutaneous melanoma: Western Canada Melanoma Study","volume":"288","author":"Elwood","year":"1984","journal-title":"Br Med J"},{"key":"10.1590\/S1807-59322011000300023_bib56","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/1523-1747.ep12347994","article-title":"Comet assay demonstrates a higher ultraviolet B sensitivity to DNA damage in dysplastic nevus cells than in common melanocytic nevus cells and foreskin melanocytes","volume":"106","author":"Noz","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1590\/S1807-59322011000300023_bib57","first-page":"9","article-title":"Hereditary dysplastic nevus syndrome: lymphoid cell ultraviolet hypermutability in association with increased melanoma susceptibility","volume":"46","author":"Perera","year":"1986","journal-title":"Cancer Res"},{"key":"10.1590\/S1807-59322011000300023_bib58","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1529-8019.2005.00050.x","article-title":"Cutaneous melanoma: Family screening and genetic testing","volume":"19","author":"Niendorf","year":"2006","journal-title":"Dermatol Ther"},{"key":"10.1590\/S1807-59322011000300023_bib59","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/01.cco.0000208791.22442.09","article-title":"Melanoma genetics: a review of genetic factor and clinical phenotypes in familial melanoma","volume":"18","author":"Pho","year":"2006","journal-title":"Curr Opin Oncol"}],"updated-by":[{"DOI":"10.1590\/s1807-59322011000700032","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000}}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S180759322201506X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S180759322201506X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.scielo.br\/pdf\/clin\/v66n3\/v66n3a23.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T22:29:11Z","timestamp":1658010551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S180759322201506X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S180759322201506X"],"URL":"https:\/\/doi.org\/10.1590\/s1807-59322011000300023","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}