{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:12:19Z","timestamp":1761743539921,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,8,30]],"date-time":"2011-08-30T00:00:00Z","timestamp":1314662400000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1590\/s1807-59322011000800016","type":"journal-article","created":{"date-parts":[[2011,9,8]],"date-time":"2011-09-08T14:33:25Z","timestamp":1315492405000},"page":"1401-1406","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association analysis of anti-Epstein-Barr nuclear antigen-1 antibodies, anti-cyclic citrullinated peptide antibodies, the shared epitope and smoking status in Brazilian patients with rheumatoid arthritis"],"prefix":"10.1016","volume":"66","author":[{"given":"Michel Alexandre","family":"Yazbek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"de Barros-Mazon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udio L\u00facio","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina","family":"Londe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian Tereza Lavras","family":"Costallat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoel Barros","family":"B\u00e9rtolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1590\/S1807-59322011000800016_bib1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0140-6736(09)60008-8","article-title":"Rheumatoid Arthritis","volume":"373","author":"Klareskog","year":"2009","journal-title":"Lancet"},{"key":"10.1590\/S1807-59322011000800016_bib2","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/BOR.0b013e32832a2e2d","article-title":"Recent progress in rheumatoid arthritis genetics","volume":"21","author":"Plenge","year":"2009","journal-title":"Curr Opin Rheumatol"},{"key":"10.1590\/S1807-59322011000800016_bib3","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/BOR.0b013e32832a2e44","article-title":"What happens before onset of rheumatoid arthritis","volume":"21","author":"Rantap\u00e4\u00e4-Dahlqvist","year":"2009","journal-title":"Curr Opin Rheumatol"},{"key":"10.1590\/S1807-59322011000800016_bib4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/BOR.0b013e32832a2e16","article-title":"Environmental influences on risk for rheumatoid arthritis","volume":"21","author":"Liao","year":"2009","journal-title":"Curr Opin Rheumatol"},{"key":"10.1590\/S1807-59322011000800016_bib5","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1002\/art.24572","article-title":"Gene-environment interaction between the DRB1 shared epitope and smoking in the risk of anti-citrullinated protein antibody-positive rheumatoid arthritis- All alleles are important","volume":"60","author":"L\u00fcndstrom","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1590\/S1807-59322011000800016_bib6","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/ard.2008.102962","article-title":"Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis","volume":"69","author":"Karlson","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1590\/S1807-59322011000800016_bib7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/art.27272","article-title":"Smoking increases rheumatoid arthritis susceptibility in individuals carrying the HLA-DRB1 shared epitope, regardless of rheumatoid factor or anti-cyclic citrullinated peptide antibody status","volume":"62","author":"Bang","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1590\/S1807-59322011000800016_bib8","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1136\/ard.2005.041079","article-title":"Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles","volume":"65","author":"Linn-Rasker","year":"2006","journal-title":"Ann rheum Dis"},{"key":"10.1590\/S1807-59322011000800016_bib9","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/ar2751","article-title":"Rheumatoid arthritis and smoking: putting the pieces together","volume":"11","author":"Baka","year":"2009","journal-title":"Arthritis Res Ter"},{"key":"10.1590\/S1807-59322011000800016_bib10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/art.21575","article-title":"A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)- restricted immune reactions to autoantigens modified by citrullination","volume":"54","author":"Klareskog","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1590\/S1807-59322011000800016_bib11","first-page":"1831","article-title":"Viruses and autoimmune disease","volume":"23","author":"Vaughan","year":"1996","journal-title":"J Rheumatol"},{"key":"10.1590\/S1807-59322011000800016_bib12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF00196166","article-title":"The Epstein-Barr virus in autoimmunity","volume":"17","author":"Vaughan","year":"1995","journal-title":"Springer Semin Immunopathol"},{"key":"10.1590\/S1807-59322011000800016_bib13","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.berh.2008.09.007","article-title":"Epstein-Barr virus in autoimmune diseases","volume":"22","author":"Toussirot","year":"2008","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1590\/S1807-59322011000800016_bib14","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/ar1893","article-title":"Epstein-Barr virus and rheumatoid arthritis: is there a link","volume":"8","author":"Costenbader","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1590\/S1807-59322011000800016_bib15","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jbspin.2007.05.001","article-title":"Pathophysiological links between rheumatoid arthritis and the Epstein-Barr virus: an update","volume":"74","author":"Toussirot","year":"2007","journal-title":"Joint Bone Spine"},{"key":"10.1590\/S1807-59322011000800016_bib16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/infdis\/164.1.22","article-title":"Analysis of antibody titers to Epstein-Barr virus nuclear antigens in sera of patients with Sj\u00f6gren's syndrome and with rheumatoid arthritis","volume":"164","author":"Inoue","year":"1991","journal-title":"J Infect Dis"},{"key":"10.1590\/S1807-59322011000800016_bib17","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1002\/art.1780241202","article-title":"Antibodies to Epstein-Barr viral antigens in early rheumatoid arthritis","volume":"24","author":"Silverman","year":"1981","journal-title":"Arthritis Rheum"},{"key":"10.1590\/S1807-59322011000800016_bib18","first-page":"1442","article-title":"Antibodies to synthetic peptides from Epstein-Barr nuclear antigen-1 in sera of patients with early rheumatoid arthritis and in preillness sera","volume":"17","author":"Kouri","year":"1990","journal-title":"J Rheumatol"},{"key":"10.1590\/S1807-59322011000800016_bib19","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/art.1780330711","article-title":"Altered immune response to glycine-rich sequences of Epstein-Barr nuclear antigen-1 in patients with rheumatoid arthritis and systemic lupus erythematosus","volume":"33","author":"Petersen","year":"1990","journal-title":"Arthritis Rheum"},{"key":"10.1590\/S1807-59322011000800016_bib20","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1172\/JCI112469","article-title":"Rheumatoid arthritis synovial membrane contains a 62,000-molecular-weight protein that shares an antigenic epitope with the Epstein-Barr virus encoded associated EBNA-1 antigen","volume":"77","author":"Fox","year":"1986","journal-title":"J Clin Invest"},{"key":"10.1590\/S1807-59322011000800016_bib21","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1136\/ard.50.11.772","article-title":"Cross-reaction of antibodies to a glycine\/alanine repeat sequence of EpsteineBarr virus nuclear antigen-1 with collagen, cytokeratin, and actin","volume":"50","author":"Baboonian","year":"1991","journal-title":"Ann Rheum Dis"},{"key":"10.1590\/S1807-59322011000800016_bib22","series-title":"HLA 1991. Proceedings of the Eleventh International Histocompatibility Workshop and Conference,vol 1","first-page":"397","article-title":"Eleventh International Histocompatibility Workshop reference protocol for the HLA DNA typing technique","author":"Kimura","year":"1992"},{"key":"10.1590\/S1807-59322011000800016_bib23","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/1529-0131(197607\/08)19:4<711::AID-ART1780190409>3.0.CO;2-I","article-title":"Serum antibody in rheumatoid arthritis reactive with a cell- associated antigen. Demonstration by precipitation and immunofluorescence","volume":"19","author":"Alpsaugh","year":"1976","journal-title":"Arthritis Rheum"},{"key":"10.1590\/S1807-59322011000800016_bib24","doi-asserted-by":"crossref","first-page":"5104","DOI":"10.1073\/pnas.86.13.5104","article-title":"Susceptibility to rheumatoid arthritis maps to a T-cell epitope shared by the HLA-Dw4 DR beta-1 chain and the Epstein-Barr virus glycoprotein gp110","volume":"86","author":"Roudier","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1590\/S1807-59322011000800016_bib25","first-page":"978","article-title":"Les proteins EBNA-1 et gp110 du virus d'EpsteinBarr sont les cibles d'une forte r\u00e9ponse anticorps chez les patients atteints de polyarthrite rhumato\u00efde qui expriment l'\u00e9pitope partag\u00e9","volume":"72","author":"Deblon","year":"2005","journal-title":"Rev Rhum"},{"key":"10.1590\/S1807-59322011000800016_bib26","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.autrev.2009.04.006","article-title":"Anti-citrullinated protein\/peptide autoantibodies in association with genetic and environmental factors as indicators of disease outcome in rheumatoid arthritis","volume":"9","author":"Szodoray","year":"2010","journal-title":"Autoimmun Rev"},{"key":"10.1590\/S1807-59322011000800016_bib27","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/art.21739","article-title":"The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis","volume":"54","author":"van der Helm-van Mil","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1590\/S1807-59322011000800016_bib28","first-page":"647","article-title":"Antibodies to viral citrullinated peptide in rheumatoid arthritis","volume":"33","author":"Anzilotti","year":"2006","journal-title":"J Rheumatol"},{"key":"10.1590\/S1807-59322011000800016_bib29","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/art.21629","article-title":"Deiminated Epstein-Barr virus nuclear antigen 1 is a target of anti-citrullinated protein antibodies in rheumatoid arthritis","volume":"54","author":"Pratesi","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1590\/S1807-59322011000800016_bib30","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1212\/WNL.0b013e3181dad57e","article-title":"Combined effects of smoking, anti-EBNA antibodies, and HLA-DRB1\u22171501 on multiple sclerosis risk","volume":"74","author":"Simon","year":"2010","journal-title":"Neurology"},{"issue":"25","key":"10.1590\/S1807-59322011000800016_bib31","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1212\/01.wnl.0000294325.63006.f8","article-title":"Integrating risk factors: HLA-DRB1\u22171501 and Epstein-Barr virus in multiple sclerosis","volume":"70","author":"De Jager","year":"2008","journal-title":"Neurology"},{"key":"10.1590\/S1807-59322011000800016_bib32","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1002\/art.10933","article-title":"Epstein-Barr virus load in the peripheral blood of patients with rheumatoid arthritis","volume":"48","author":"Balandraud","year":"2003","journal-title":"Arhtritis Rheum"},{"key":"10.1590\/S1807-59322011000800016_bib33","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1093\/rheumatology\/kem193","article-title":"IgG, IgA, IgM antibodies to a viral citrullinated peptide in patients affected by rheumatoid arthritis, chronic arthritides and connective tissue disorders","volume":"46","author":"Anzilotti","year":"2007","journal-title":"Rheumatology (Oxford)"},{"key":"10.1590\/S1807-59322011000800016_bib34","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1590\/S0100-879X2008005000021","article-title":"A majority of Brazilian patients with rheumatoid arthritis HLA-DRB1 alleles carry both the HLA-DRB1 shared epitope and anti-citrunillated peptide antibodies","volume":"41","author":"Louzada-Junior","year":"2008","journal-title":"Braz J Med Biol Res"},{"key":"10.1590\/S1807-59322011000800016_bib35","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s12016-007-8017-2","article-title":"Share epitope, citrullinated cyclic peptide antibodies and smoking in Brazilian rheumatoid arthritis patients","volume":"34","author":"Oliveira","year":"2008","journal-title":"Clin Rev Allergy Immunol"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222019792?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222019792?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.scielo.br\/pdf\/clin\/v66n8\/16.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:09:17Z","timestamp":1761721757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593222019792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S1807593222019792"],"URL":"https:\/\/doi.org\/10.1590\/s1807-59322011000800016","relation":{},"ISSN":["1807-5932"],"issn-type":[{"type":"print","value":"1807-5932"}],"subject":[],"published":{"date-parts":[[2011,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association analysis of anti-Epstein-Barr nuclear antigen-1 antibodies, anti-cyclic citrullinated peptide antibodies, the shared epitope and smoking status in Brazilian patients with rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1590\/S1807-59322011000800016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 CLINICS. Published by Elsevier Spain","name":"copyright","label":"Copyright"}]}}