{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:24:21Z","timestamp":1792272261721,"version":"4.4.0"},"reference-count":51,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Bras. Parasitol. Vet."],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>The increased incidence of visceral leishmaniasis (VL) in Brazil is due to a lack of effective disease control measures. In addition to that, no effective treatment exists for canine VL in response to synthetic drugs. Thus, the objective of this study was to evaluate the effect of the essential oils of Coriandrum sativum and Lippia sidoides, and oleoresin from Copaifera reticulata, on Leishmania chagasi promastigotes and amastigotes. We also examined the toxicity of these treatments on the murine monocyte cell line RAW 264.7. To determine the IC50 a MTT test (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) was performed on promastigotes, and an in situ ELISA assay was conducted on amastigotes. Here, we demonstrate that oleoresin from C. reticulata was effective against both promastigotes (IC50 of 7.88 \u00b5g.mL-1) and amastigotes (IC50 of 0.52 \u00b5g.mL-1), and neither of the two treatments differed significantly (p &gt; 0.05) from pentamidine (IC50 of 2.149 \u00b5g.mL-1) and amphotericin B (IC50 of 9.754 \u00b5g.mL-1). Of the three plant oils tested, only oleoresin showed no toxicity toward monocyte, with 78.45% viability after treatment. Inhibition of promastigote and amastigote growth and the lack of cytotoxicity by C. reticulata demonstrate that oleoresin may be a viable option for analyzing the in vivo therapeutic effects of leishmanicidal plants<\/jats:p>","DOI":"10.1590\/s1984-29612012000300002","type":"journal-article","created":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T11:38:43Z","timestamp":1350041923000},"page":"185-191","source":"Crossref","is-referenced-by-count":33,"title":["In vitro efficacy of Coriandrum sativum, Lippia sidoides and Copaifera reticulata against Leishmania chagasi"],"prefix":"10.1590","volume":"21","author":[{"given":"Fernanda Cristina Macedo","family":"Rondon","sequence":"first","affiliation":[{"name":"Universidade Estadual do Cear\u00e1, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Maria Leal","family":"Bevilaqua","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Cear\u00e1, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Parissi","family":"Accioly","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Cear\u00e1, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selene Maia de","family":"Morais","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Cear\u00e1, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heitor Franco de","family":"Andrade-J\u00fanior","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Aparecida de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josemar Coelho","family":"Lima","sequence":"additional","affiliation":[{"name":"Embrapa Agroind\u00fastria Tropical, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilton C\u00e9sar Rodrigues","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Embrapa Agroind\u00fastria Tropical, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","series-title":"Identification of essential oils by ion trap mass spectroscopy","author":"Adams RP","year":"1989"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jep.2007.09.007","article-title":"Acute diuretic effect of continuous intravenous infusion of an aqueous extract of Coriandrum sativum L. in anesthetized rats","volume":"115","author":"Aissaoui A","year":"2008","journal-title":"J Ethnopharmacol","ISSN":"https:\/\/id.crossref.org\/issn\/0378-8741","issn-type":"print"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1021\/np50035a028","article-title":"Kovats' indices as a preselection 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