{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:10:02Z","timestamp":1761581402961},"reference-count":38,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Bras. Parasitol. Vet."],"abstract":"<jats:p>Abstract The aim of this work was a correlation study and histopathological description of alterations associated with the presence of Leishmania infantumamastigote in the intestinal wall of dogs infected with canine visceral leishmaniasis (CVL). Three groups were used: G1 (n = 8), comprising naturally infected dogs with CVL with amastigotes of L. infantum in the small and large intestines; G2 (n = 9), infected dogs with CVL, without intestinal amastigotes; and G3 (n = 3), uninfected dogs. Histochemistry and immunohistochemistry methods were used for histopathology and amastigotes identification. 47.1% (8\/17) of dogs from G1 group had amastigotes in the mucosa, submucosa and muscle layers of the small and large intestines and it was observed a prominent inflammatory reaction characterized by chronic infiltration of mononuclear cells: macrophages, lymphocytes and plasma cells. Comparison between the groups showed only a significant difference in relation to mucosal microscopic structural alterations in dogs from G1 in relation to G2 and G3. Parasite burden showed significant correlations with the microscopic alterations and clinical status of dogs in G1. By the conclusion, the inflammatory reactions caused by the parasites in the intestines might have contributed towards alterations in digestive processes, worsening the dogs\u2019 clinical status of CVL.<\/jats:p>","DOI":"10.1590\/s1984-29612016009","type":"journal-article","created":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T23:19:09Z","timestamp":1457565549000},"page":"24-36","source":"Crossref","is-referenced-by-count":10,"title":["Correlation study and histopathological description of intestinal alterations in dogs infected with Leishmania infantum"],"prefix":"10.1590","volume":"25","author":[{"given":"Diogo Tiago","family":"Silva","sequence":"first","affiliation":[{"name":"Universidade Estadual Paulista, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Francisca","family":"Neves","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina Mari Gual Pimenta de","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio Cesar Pereira","family":"Spada","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luana","family":"Alves","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Fl\u00f3ro e Silva","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willian Marinho Dourado","family":"Coelho","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Educacional de Andradina, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan Rodrigo","family":"Panosso","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Carlos Faconti","family":"Noronha Junior","sequence":"additional","affiliation":[{"name":"Centro de Controle de Zoonoses, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilma Aparecida","family":"Starke-Buzetti","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2016,3,11]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4269\/ajtmh.2007.76.53","article-title":"Asymptomatic colitis in naturally infected dogs withLeishmania infantum: a prospective study","volume":"76","author":"Adamama-Moraitou KK","year":"2007","journal-title":"Am J Trop Med 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