{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T15:44:51Z","timestamp":1769096691616,"version":"3.49.0"},"reference-count":14,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Bras. Parasitol. Vet."],"abstract":"<jats:p>Abstract Leishmania infantum chagasi liver parasite load was compared to hemostatic abnormalities, as well as to clinical, laboratorial, and histopathological findings in dogs with visceral leishmaniasis. The liver parasite load of 30 dogs L. infantum chagasi naturally-infected was evaluated by quantitative real- time PCR and the results were compared with serum biochemistry and primary and secondary hemostasis findings. Moreover, hepatic histological lesions were described in these dogs. Prolonged bleeding time, prothrombin time (PT), and activated partial thromboplastin time (APTT), were observed in the group with visceral leishmaniasis. Eleven dogs presented inflammatory liver lesions, with predominance of mild multifocal mononuclear periportal hepatitis. No association between the presence of parasites and abnormalities in screening tests was observed by Spearman\u2019s rank correlation coefficient. The clinical progression in leishmaniasis is associated with the occurrence of hemorrhagic diathesis, which depends not only on the presence of the parasite but also the inflammatory process, compromised immunological response, hepatic and renal failure in symptomatic dogs.<\/jats:p>","DOI":"10.1590\/s1984-29612016036","type":"journal-article","created":{"date-parts":[[2016,6,11]],"date-time":"2016-06-11T12:32:44Z","timestamp":1465648364000},"page":"244-247","source":"Crossref","is-referenced-by-count":3,"title":["Hemostatic assessment of dogs associated with hepatic parasite load of Leishmania infantum chagasi"],"prefix":"10.1590","volume":"25","author":[{"given":"Mariana de Medeiros","family":"Torres","sequence":"first","affiliation":[{"name":"Universidade Federal de Mato Grosso,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arleana do Bom Parto Ferreira de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daphine Ariadne Jesus de","family":"Paula","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriane Jorge","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Nakazato","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline Argenta","family":"Pescador","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria R\u00e9gia Franco","family":"Sousa","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2016,6,14]]},"reference":[{"issue":"3","key":"ref1","first-page":"127","article-title":"Infec\u00e7\u00e3o por Ehrlichia canis e Anaplasma platys em cadelas e neonatos de Cuiab\u00e1, Mato Grosso","volume":"15","author":"Almeida ABPF","year":"2010","journal-title":"Arch Vet Sci"},{"issue":"3-4","key":"ref2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.vetpar.2006.03.031","article-title":"Use of PCR-RFLP to identify Leishmania species in naturally-infected dogs","volume":"140","author":"Andrade HM","year":"2006","journal-title":"Vet Parasitol"},{"issue":"22","key":"ref3","doi-asserted-by":"crossref","first-page":"4502","DOI":"10.1016\/j.vaccine.2007.03.014","article-title":"DNA vaccination against the parasite enzyme gamma-glutamylcysteine synthetase confers protection against Leishmania donovani infection","volume":"25","author":"Carter 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