{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T20:14:10Z","timestamp":1785615250575,"version":"3.56.0"},"reference-count":82,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Bras. Parasitol. Vet."],"abstract":"<jats:p>Abstract The anthelminthic activity of the essential oil (EO) of Piper aduncum L. was tested in vitro on eggs and larvae of resistant (Embrapa2010) and susceptible (McMaster) isolates of Haemonchus contortus. The EO was obtained by steam distillation and its components identified by chromatography. EO concentrations of 12.5 to 0.02 mg\/mL were used in the egg hatch test (EHT) and concentrations of 3.12 to 0.01 mg\/mL in the larval development test (LDT). Inhibition concentrations (IC) were determined by the SAS Probit procedure, and significant differences assessed by ANOVA followed by Tukey\u2019s test. In the EHT, the IC50 for the susceptible isolate was 5.72 mg\/mL. In the LDT, the IC50 and IC90 were, respectively, 0.10 mg\/mL and 0.34 mg\/mL for the susceptible isolate, and 0.22 mg\/mL and 0.51 mg\/mL for the resistant isolate. The EO (dillapiole 76.2%) was highly efficacious on phase L1. Due to the higher ICs obtained for the resistant isolate, it was raised the hypothesis that dillapiole may have a mechanism of action that resembles those of other anthelmintic compounds. We further review and discuss studies, especially those conducted in Brazil, that quantified the major constituents of P. aduncum-derived EO.<\/jats:p>","DOI":"10.1590\/s1984-29612016073","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T21:42:01Z","timestamp":1480542121000},"page":"383-393","source":"Crossref","is-referenced-by-count":19,"title":["Piper aduncum against Haemonchus contortus isolates: cross resistance and the research of natural bioactive compounds"],"prefix":"10.1590","volume":"25","author":[{"given":"Yousmel Alem\u00e1n","family":"Ga\u00ednza","sequence":"first","affiliation":[{"name":"Centro Nacional de Sanidad Agropecuaria, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela Regina","family":"Fantatto","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Celio Maia","family":"Chaves","sequence":"additional","affiliation":[{"name":"Embrapa Amaz\u00f4nia Ocidental, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto Ribeiro","family":"Bizzo","sequence":"additional","affiliation":[{"name":"Embrapa Agroind\u00fastria de Alimentos, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio Novita","family":"Esteves","sequence":"additional","affiliation":[{"name":"Embrapa Pecu\u00e1ria Sudeste, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina de Souza","family":"Chagas","sequence":"additional","affiliation":[{"name":"Embrapa Pecu\u00e1ria Sudeste, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2016,12,1]]},"reference":[{"key":"ref1","series-title":"Identification of essential oils components by gas chromatography\/mass spectrometry","author":"Adams RP","year":"2007","edition":"4th"},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1002\/cbdv.200800212","article-title":"Chemical variation in Piper aduncum and biological properties of its dillapiole-rich essential oil","volume":"6","author":"Almeida RRP","year":"2009","journal-title":"Chem Biodivers"},{"key":"ref3","series-title":"Isolamento, purifica\u00e7\u00e3o e isomeriza\u00e7\u00e3o do dilapiol, componente majorit\u00e1rio do \u00f3leo essencial de P. aduncum para comprova\u00e7\u00e3o de sua atividade biol\u00f3gica","author":"Almeida RRP","year":"2004"},{"key":"ref4","series-title":"Variabilidade qu\u00edmica em \u00f3leos essenciais de esp\u00e9cies de Piper da Amaz\u00f4nia","author":"Andrade EHA","year":"2009","edition":"22nd"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s10493-012-9545-x","article-title":"Acaricidal activity and repellency of essential oil from Piper aduncum and its components against Tetranychus urticae.","volume":"57","author":"Ara\u00fajo MJC","year":"2012","journal-title":"Exp Appl Acarol"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/0972060X.2008.10643597","article-title":"Essential oils from Bolivia. VIII. Piperaceae: Piper heterophyllum Ruiz et Pav\u00f3n, P. aduncum L","volume":"11","author":"Arze JBL","year":"2008","journal-title":"J Ess Oil Bearing-Pl"},{"issue":"8","key":"ref7","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1590\/S0100-40422007000800030","article-title":"Seasonal variation in the composition of volatile oils from Schinus terebinthifolius raddi","volume":"30","author":"Barbosa LCA","year":"2007","journal-title":"Quim Nova"},{"issue":"8","key":"ref8","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.3390\/molecules13081864","article-title":"Evaluation of the chemical composition of Brazilian commercial Cymbopogon citratus (D.C.) stapf samples","volume":"13","author":"Barbosa LCA","year":"2008","journal-title":"Molecules"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/pest.1999.2453","article-title":"Dillapiol derivatives as synergists: structure-activity relationship analysis","volume":"66","author":"Belzile AS","year":"2000","journal-title":"Pestic Biochem Physiol"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1570-7458.1990.tb01411.x","article-title":"In vivo effect of mixtures of allelochemicals on the life cycle of the European corn borer, Ostrinia nubilalis.","volume":"57","author":"Bernard CB","year":"1990","journal-title":"Entomol Exp Appl"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/BF02033462","article-title":"Insecticidal defenses of Piperaceae from the neotropics","volume":"21","author":"Bernard CB","year":"1995","journal-title":"J Chem Ecol"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/ffj.957","article-title":"Sarisan from leaves of Piper affinis hispidinervum C. DC (long pepper)","volume":"16","author":"Bizzo HR","year":"2001","journal-title":"Flavour Fragrance J"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1590\/S0102-695X2007000400014","article-title":"Influence of season, harvest time and drying on Java citronella (Cymbopogon winterianus Jowitt) volatile oil","volume":"17","author":"Blank AF","year":"2007","journal-title":"Rev Brasil Farmacogn"},{"issue":"6","key":"ref14","first-page":"517","article-title":"Antibacterial activity of the Piper aduncum oil and dillapiole, its main constituent, against multidrug-resistant strains","volume":"13","author":"Braz\u00e3o MAB","year":"2014","journal-title":"Bol Latinoam Caribe Plantas Med Aromat"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.parint.2012.07.001","article-title":"Haemonchus contortus: a multiple-resistant Brazilian isolate and the costs for its characterization and maintenance for research use","volume":"62","author":"Chagas ACS","year":"2013","journal-title":"Parasitol Int"},{"key":"ref16","series-title":"Manual pr\u00e1tico: metodologias de diagn\u00f3stico da resist\u00eancia e de detec\u00e7\u00e3o de subst\u00e2ncias ativas em parasitas de ruminantes","author":"Chagas ACS","year":"2011"},{"issue":"S1","key":"ref17","first-page":"156","article-title":"Controle de parasitas utilizando extratos vegetais","volume":"13","author":"Chagas ACS","year":"2004","journal-title":"Rev Bras Parasitol Vet"},{"issue":"2","key":"ref18","first-page":"783","article-title":"Constituyentes vol\u00e1tiles de las hojas y espigas de Piper aduncum (Piperaceae) de Costa Rica","volume":"45","author":"Cicci\u00f3 JF","year":"1997","journal-title":"Rev Biol Trop"},{"issue":"1-2","key":"ref19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0304-4017(92)90141-U","article-title":"World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) methods for the detection of anthelmintic resistance in nematodes of veterinary importance","volume":"44","author":"Coles GC","year":"1992","journal-title":"Vet Parasitol"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1590\/S1413-70542007000100017","article-title":"Propriedade inseticida dos \u00f3leos essenciais de Piper hispidinervum C. DC.; Piper aduncum L. e Tanaecium nocturnum (Barb. Rodr.) Bur. & K. Shum sobre Tenebrio molitor L., 1758","volume":"31","author":"Fazolin M","year":"2007","journal-title":"Cienc Agrotec"},{"key":"ref21","series-title":"Potencialidades da pimenta-de-macaco (Piper aduncum L.): caracter\u00edsticas gerais e resultados de pesquisa","author":"Fazolin M","year":"2006"},{"key":"ref22","series-title":"Medicinal plants: phytochemistry, pharmacology and therapeutics","first-page":"423","volume-title":"Amazon Piperaceae with potential insecticide use","volume":"3","author":"Fazolin M","year":"2014"},{"key":"ref23","series-title":"Trocas gasosas, biomassa, teor e composi\u00e7\u00e3o do \u00f3leo essencial de folhas e ra\u00edzes de Piper aduncum L. sob diferentes n\u00edveis de luminosidade","author":"Ferreira MI","year":"2011"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/ffj.1875","article-title":"Factors affecting secondary metabolite production in plants: volatile components and essential oils","volume":"23","author":"Figueiredo AC","year":"2008","journal-title":"Flavour Fragrance J"},{"issue":"3-4","key":"ref25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0304-4017(02)00321-7","article-title":"Amphidial structure of ivermectin-resistant and susceptible laboratory and field strains of Haemonchus contortus.","volume":"110","author":"Freeman AS","year":"2003","journal-title":"Vet Parasitol"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1590\/S0102-695X2010005000026","article-title":"Varia\u00e7\u00e3o dos teores de constituintes vol\u00e1teis de Cymbopogon citratus (DC) Staf, Poaceae, coletados em diferentes regi\u00f5es do Estado de S\u00e3o Paulo","volume":"20","author":"Furlan MR","year":"2010","journal-title":"Rev Bras Farmacogn"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0020-7519(94)00087-5","article-title":"Avermectin inhibition of larval development in Haemonchus contortus - Effects of ivermectin resistance","volume":"25","author":"Gill JH","year":"1995","journal-title":"Int J Parasitol"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1590\/1809-43921981111143","article-title":"\u00d3leos essenciais da Amaz\u00f4nia VII","volume":"11","author":"Gottlieb OR","year":"1981","journal-title":"Acta Amazon"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.etap.2008.08.002","article-title":"Bioactivities of Piper aduncum L. and Piper obliquum Ruiz & Pavon (Piperaceae) essential oils from Eastern Ecuador","volume":"27","author":"Guerrini A","year":"2009","journal-title":"Environ Toxicol Pharmacol"},{"key":"ref30","series-title":"Lista de esp\u00e9cies da flora do Brasil","volume-title":"Piperaceae","author":"Guimar\u00e3es EF","year":"2015"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1590\/S0100-40422008000600037","article-title":"Influ\u00eancia da luz e da temperatura sobre a oxida\u00e7\u00e3o do \u00f3leo essencial de capim-lim\u00e3o (Cymbopogon citratus (DC.) Stapf)","volume":"31","author":"Guimar\u00e3es LG","year":"2008","journal-title":"Quim Nova"},{"issue":"1","key":"ref32","first-page":"35","article-title":"The composition of the essential oil of Piper aduncum L. from Panama","volume":"14","author":"Gupta MP","year":"1983","journal-title":"Rev Latinoamer Quim"},{"key":"ref33","series-title":"270 Plantas Medicinales Iberoamericanas","author":"Gupta MP","year":"1995"},{"key":"ref34","series-title":"Caracteriza\u00e7\u00e3o da diversidade gen\u00e9tica via marcador microssat\u00e9lite, e constituintes do \u00f3leo essencial de Lychnophora pinaste MART","author":"Haber LL","year":"2008"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/jee\/92.3.676","article-title":"Bioactivities of safrole and isosafrole on Sitophilus zeamais (Coleoptera: Curculionidae) and Tribolium castaneum (Coleoptera: Tenebrionidae)","volume":"92","author":"Huang Y","year":"1999","journal-title":"J Econ Entomol"},{"issue":"20","key":"ref36","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1136\/vr.130.20.442","article-title":"A microlarval development assay for the detection of anthelmintic resistance in sheep nematodes","volume":"130","author":"Hubert J","year":"1992","journal-title":"Vet Rec"},{"key":"ref37","series-title":"Flavours and fragrances chemistry, bioprocessing and sustainability","first-page":"43","volume-title":"Chemistry of essential oils","author":"Husnu K","year":"2007"},{"key":"ref38","series-title":"ISO 9235:2013: aromatic natural raw materials: vocabulary","year":"2013"},{"issue":"7","key":"ref39","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.pt.2009.04.004","article-title":"Drug resistance mechanisms in helminths: is it survival of the fittest?","volume":"25","author":"James CE","year":"2009","journal-title":"Trends Parasitol"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/ffj.2730090611","article-title":"A comparative study of the essential oils of five Piper species from Peninsular Malaysia","volume":"9","author":"Jantan BI","year":"1994","journal-title":"Flavour Fragrance J"},{"issue":"4","key":"ref41","doi-asserted-by":"crossref","first-page":"706","DOI":"10.2307\/2657072","article-title":"Phylogeny and patterns of floral diversity in the genus Piper (Piperaceae)","volume":"88","author":"Jaramillo MA","year":"2001","journal-title":"Am J Bot"},{"issue":"1-2","key":"ref42","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.vetpar.2011.07.001","article-title":"Anthelmintic activity of Cymbopogon martinii, Cymbopogon schoenanthus and Mentha piperita essential oils evaluated in four different in vitro tests","volume":"183","author":"Katiki LM","year":"2011","journal-title":"Vet Parasitol"},{"issue":"4","key":"ref43","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1351\/pac200779040529","article-title":"Chemistry and evolution of the Piperaceae","volume":"79","author":"Kato MJ","year":"2007","journal-title":"Pure Appl Chem"},{"issue":"3-4","key":"ref44","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.vetpar.2005.11.001","article-title":"Synergism of rotenone by piperonyl butoxide in Haemonchus contortus and Trichostrongylus colubriformis in vitro: Potential for drug-synergism through inhibition of nematode oxidative detoxification pathways","volume":"136","author":"Kotze AC","year":"2006","journal-title":"Vet Parasitol"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1645\/0022-3395(2000)086[0873:OAIMRA]2.0.CO;2","article-title":"Oxidase activities in macrocyclic-resistant and -susceptible Haemonchus contortus.","volume":"86","author":"Kotze AC","year":"2000","journal-title":"J Parasitol"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/ffj.1160","article-title":"Composition and niticidal activity of essential oils of three chemotypes of Rosmarinus officinalis L. acclimatized in Morocco","volume":"18","author":"Lahlou M","year":"2003","journal-title":"Flav Frag J"},{"issue":"21","key":"ref47","first-page":"3800","article-title":"Antimicrobial activity of essential oil of Piper aduncum L. (Piperaceae)","volume":"6","author":"Lara-J\u00fanior CR","year":"2012","journal-title":"J. Med. Plants Res"},{"issue":"2","key":"ref48","first-page":"61","article-title":"Produ\u00e7\u00e3o de biomassa e \u00f3leo essencial em plantas de capim cidreira [Cymbopogon citratus (Dc.). Stapf] em diferentes idades","volume":"5","author":"Leal TCAB","year":"2003","journal-title":"Rev Bras Pl Med"},{"issue":"2","key":"ref49","first-page":"1","article-title":"Evaluation of Piper aduncum Linn. essential oil (Fam: Piperaceae) against Periplaneta americana (L.)","volume":"3","author":"Ling IA","year":"2009","journal-title":"Iran J Arthropod-Borne Dis"},{"issue":"2","key":"ref50","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.beproc.2009.06.009","article-title":"Tannins and self-medication: implications for sustainable parasite control in herbivores","volume":"82","author":"Lisonbee LD","year":"2009","journal-title":"Behav Processes"},{"key":"ref51","series-title":"Plantas medicinais no Brasil: nativas e ex\u00f3ticas","author":"Lorenzi H","year":"2002"},{"issue":"4","key":"ref52","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/(SICI)1099-1026(1998070)13:4<269::AID-FFJ744>3.0.CO;2-A","article-title":"Constituents of the essential oil of Piper aduncum L. growing wild in the Amazon region","volume":"13","author":"Maia JGS","year":"1998","journal-title":"Flavour Fragrance J"},{"issue":"3","key":"ref53","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1590\/S0102-05362007000300020","article-title":"Caracter\u00edsticas do \u00f3leo essencial de capim-citronela em fun\u00e7\u00e3o de espa\u00e7amento, altura e \u00e9poca de corte","volume":"25","author":"Marco CA","year":"2007","journal-title":"Hortic Bras"},{"issue":"1","key":"ref54","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1590\/S0102-695X2005000100003","article-title":"Estudo comparativo dos \u00f3leos vol\u00e1teis de algumas esp\u00e9cies de Piperaceae","volume":"15","author":"Mesquita JMO","year":"2005","journal-title":"Rev Bras Farm"},{"issue":"6","key":"ref55","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1021\/jf60226a033","article-title":"New methylenedioxyphenyl synergists for pyrethrins","volume":"27","author":"Mukerjee SK","year":"1979","journal-title":"J Agric Food Chem"},{"issue":"3","key":"ref56","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1590\/S0100-40422006000300012","article-title":"Composition and antifungal activity of essential oils from Piper aduncum, Piper arboreum and Piper tuberculatum.","volume":"29","author":"Navickiene HMD","year":"2006","journal-title":"Quim Nova"},{"issue":"7","key":"ref57","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1094\/PHYTO.2000.90.7.710","article-title":"Nematicidal activity of essential oils and their components against the root-knot nematode","volume":"90","author":"Oka Y","year":"2000","journal-title":"Phytopathology"},{"issue":"5","key":"ref58","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1590\/S0102-695X2013000500005","article-title":"Growth study and essential oil analysis of Piper aduncum L. from two sites of Cerrado biome of Minas Gerais State, Brazil","volume":"23","author":"Oliveira GL","year":"2013","journal-title":"Rev Bras Farmacogn"},{"issue":"3","key":"ref59","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.bjp.2014.07.004","article-title":"Chemical composition and efficacy in the egg-hatching inhibition of essential oil of Piper aduncum against Haemonchus contortus from sheep","volume":"24","author":"Oliveira GL","year":"2014","journal-title":"Rev Bras Farmacogn"},{"issue":"5","key":"ref60","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1080\/10412905.2006.9699166","article-title":"Volatile constituents of the leaf oils of Piper aduncum L. from different regions of Pernambuco (Northeast of Brazil)","volume":"18","author":"Oliveira JCS","year":"2006","journal-title":"J Essent Oil Res"},{"issue":"8","key":"ref61","doi-asserted-by":"crossref","first-page":"723","DOI":"10.3923\/ijps.2006.723.730","article-title":"Essential oils on mixed Coccidia vaccination and infection in broilers","volume":"5","author":"Oviedo-Rond\u00f3n EO","year":"2006","journal-title":"Int J Poult Sci"},{"issue":"12","key":"ref62","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/ardp.201200212","article-title":"Dillapiole as antileishmanial agent: discovery, cytotoxic activity and preliminary SAR studies of dillapiole analogues","volume":"345","author":"Parise-Filho R","year":"2012","journal-title":"Arch Pharm"},{"issue":"11","key":"ref63","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.3109\/13880209.2011.575793","article-title":"The anti-inflammatory activity of dillapiole and some semisynthetic analogues","volume":"49","author":"Parise-Filho R","year":"2011","journal-title":"Pharm Biol"},{"issue":"2","key":"ref64","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1080\/10412905.2004.9698670","article-title":"Essential oils of Piper peltata (L.) Miq. and Piper aduncum L. from Cuba","volume":"16","author":"Pino JA","year":"2004","journal-title":"J Essent Oil Res"},{"issue":"1","key":"ref65","first-page":"52","article-title":"Caracterizaci\u00f3n qu\u00edmica y actividad acaricida del aceite esencial de Piper aduncum subsp. ossanum frente a Varroa destructor.","volume":"26","author":"Pino O","year":"2011","journal-title":"Rev Protecci\u00f3n Veg"},{"issue":"1","key":"ref66","doi-asserted-by":"crossref","first-page":"7","DOI":"10.32712\/2446-4775.2006.37","article-title":"Piper aduncum L.: pluripotente plant and important phytochemical substance source","volume":"2","author":"Pohlit AM","year":"2006","journal-title":"Rev Fitos"},{"issue":"1","key":"ref67","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bse.2011.12.025","article-title":"Chemical characterization of essential oil constituents of four populations of Piper aduncum L. from Distrito Federal, Brazil","volume":"42","author":"Potzernheim MCL","year":"2012","journal-title":"Biochem Syst Ecol"},{"issue":"1","key":"ref68","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.supflu.2008.02.015","article-title":"Obtaining \u03b2-caryophyllene from Cordia verbenacea de Candolle by supercritical fluid extraction","volume":"46","author":"Quispe-Condori S","year":"2008","journal-title":"J Supercrit Fluids"},{"issue":"3","key":"ref69","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3390\/12030389","article-title":"Volatile chemical constituents of Piper aduncum L. and Piper gibbilimbum C. DC (Piperaceae) from Papua New Guinea","volume":"12","author":"Rali T","year":"2007","journal-title":"Molecules"},{"issue":"1","key":"ref70","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1071\/AR9500099","article-title":"Methods for egg counts and larval cultures for strongyles infesting the gastro-intestinal tract of cattle","volume":"1","author":"Roberts FHS","year":"1950","journal-title":"Aust J Agric Res"},{"issue":"1","key":"ref71","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/B978-0-12-407705-8.00004-5","article-title":"Next-generation molecular-diagnostic tools for gastrointestinal nematodes of livestock, with an emphasis on small ruminants: a turning point?","volume":"83","author":"Roeber F","year":"2013","journal-title":"Adv Parasitol"},{"issue":"1","key":"ref72","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11101-006-9058-5","article-title":"A review of Piper spp. (Piperaceae) phytochemistry, insecticidal activity and mode of action","volume":"7","author":"Scott IM","year":"2008","journal-title":"Phytochem Rev"},{"issue":"2-4","key":"ref73","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.vetpar.2009.06.006","article-title":"Toxicity of Piper aduncum L. (Piperales: Piperaceae) from the Amazon forest for the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae)","volume":"164","author":"Silva WC","year":"2009","journal-title":"Vet Parasitol"},{"issue":"4","key":"ref74","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.exppara.2009.08.002","article-title":"Inhibitory effect of essential oils of Allium sativum and Piper longum on spontaneous muscular activity of liver fluke, Fasciola gigantica.","volume":"123","author":"Singh TU","year":"2009","journal-title":"Exp Parasitol"},{"issue":"1","key":"ref75","first-page":"127","article-title":"Essential oil of Piper aduncum from Fiji","volume":"2","author":"Smith RM","year":"1979","journal-title":"New Zeal J Sci"},{"issue":"2","key":"ref76","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1590\/S0102-695X2008000200013","article-title":"Avalia\u00e7\u00e3o toxicol\u00f3gica do \u00f3leo essencial de Piper aduncum L","volume":"18","author":"Sousa PJC","year":"2008","journal-title":"Rev Bras Farmacogn"},{"key":"ref77","series-title":"Atividades repelente e inseticida de \u00f3leos essenciais de Piper spp Linnaeus da Amaz\u00f4nia em Anopheles marajoara Galv\u00e3o e Damasceno, Stegomyia aegypti Linnaeus (D\u00edptera: Culicidae) e Solenopsis saevissima Fr. 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