{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T11:43:03Z","timestamp":1768736583237,"version":"3.49.0"},"reference-count":45,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Bras. Parasitol. Vet."],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>Abstract Toxoplasmosis, a disease caused by Toxoplasma gondii, is an important health problem, especially in immunocompromised hosts. T. gondii uses the gut wall as an infection gateway, with tropism for muscular and nervous tissues causing intestinal alterations, including some in the enteric nervous system. This study aims at investigating the colon of rats infected by T. gondii in order to understand how the amount of oocysts influences in myenteric neuronal changes. Sixty Wistar rats (Rattus norvegicus) were divided into six groups. One group remained as a control and the others received inocula of 10, 50, 100, 500 or 5,000 oocysts of T. gondii. The animals were euthanized after 30 days of infection. The total neuronal population and the nitrergic subpopulation in the colon myenteric plexus of each animal was counted. The data were statistically analyzed showing less weight gain in rats with 10, 500 and 5,000 oocysts. A decrease in the number of total neurons with 50, 100 or 5,000 oocysts and an increase in the nitrergic population with 10, 100, 500 or 5,000 oocysts were verified. These results show that neuronal alterations are more significant when the infection is induced by larger inocula and reinforces the suspicion that neuronal loss is directed at cholinergic neurons.<\/jats:p>","DOI":"10.1590\/s1984-29612017003","type":"journal-article","created":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T13:25:28Z","timestamp":1491830728000},"page":"47-53","source":"Crossref","is-referenced-by-count":9,"title":["Different inoculum loads of Toxoplasma gondii induce reduction of myenteric neurons of the rat colon"],"prefix":"10.1590","volume":"26","author":[{"given":"Rafael Isolani","family":"Ferezin","sequence":"first","affiliation":[{"name":"Universidade Estadual de Maring\u00e1, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suellen Lais","family":"Vicentino-Vieira","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Maring\u00e1, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Biondaro","family":"G\u00f3is","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Maring\u00e1, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Jos\u00e9 de Almeida","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Londrina, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gessilda de Alc\u00e2ntara Nogueira de","family":"Melo","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Maring\u00e1, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Luis","family":"Garcia","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Londrina, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora de Mello Gon\u00e7ales","family":"Sant'Ana","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Maring\u00e1, 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