{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:10:27Z","timestamp":1790424627694,"version":"4.1.0"},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Bras. Parasitol. Vet."],"abstract":"<jats:p>Abstract Platynosomiasis is a common feline hepatic disease caused by Platynosomum fastosum (Trematoda - Dicrocoelidae), which is also known as \u2018lizard poisoning\u2019. Most reports of feline platynosomiasis show that this disease is sporadic and manifests with uncommon lesions; its pathogenicity is still not well understood. This study aimed to describe liver injuries and enzymatic changes associated with natural P. fastosum infection in 47 stray cats in an endemic area. Overall, 38.3% (18\/47) of cats were parasitized, and 2,358 flukes (P. fastosum) were collected (131 \u2013 mean intensity of parasitism; 50.2 \u2013 mean abundance). The alanine transaminase (ALT) measure was significantly higher in parasitized animals, while alkaline phosphatase (ALP) showed no statistical difference between parasitized and non-parasitized animals. In infected animals, gross pathological lesions and microscopic liver injuries ranged from mild to severe, and were similar to those in previous descriptions of feline platynosomiasis. Nonetheless, the intensity of parasitism was not related to the severity of macroscopic or microscopic hepatic injuries. However, feline platynosomiasis should be considered in the differential diagnosis of feline liver disorders, as well as, in any program of helminth control, even if no clinical abnormalities are present.<\/jats:p>","DOI":"10.1590\/s1984-29612017009","type":"journal-article","created":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T14:08:39Z","timestamp":1489673319000},"page":"54-59","source":"Crossref","is-referenced-by-count":16,"title":["Feline platynosomiasis: analysis of the association of infection levels with pathological and biochemical findings"],"prefix":"10.1590","volume":"26","author":[{"given":"Dirceu Guilherme de Souza","family":"Ramos","sequence":"first","affiliation":[{"name":"Universidade Federal de Goi\u00e1s, Brasil; Centro Universit\u00e1rio de Mineiros, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Raiza Gon\u00e7alves Lima Oliveira","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leodil da Costa","family":"Freitas","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00cdsis Assis","family":"Braga","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio de Mineiros, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica Pereira da","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Maria Curtio","family":"Soares","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e1dia Aline Bobbi","family":"Antoniassi","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Henrique","family":"Furlan","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard de Campos","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2017,3,16]]},"reference":[{"key":"ref1","series-title":"Veterinary Hematology and Clinical Chemistry","volume-title":"Laboratory evaluation of the liver","author":"Allison RW","year":"2012","edition":"2nd"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2460\/javma.2001.218.669","article-title":"Report of the AVMA panel on Euthanasia","volume":"218","year":"2001","journal-title":"J Am Vet Med Assoc"},{"issue":"1-2","key":"ref3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.vetpar.2012.04.015","article-title":"Platynosomum fastosum-induced cholangiocarcinomas in cats","volume":"190","author":"Andrade RL","year":"2012","journal-title":"Vet Parasitol"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2307\/3275412","article-title":"Helminth parasites of dogs and cats in Hawaii","volume":"48","author":"Ash LR","year":"1962","journal-title":"J Parasitol"},{"issue":"1-2","key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetpar.2013.12.016","article-title":"A review of the cat liver fluke Platynosomum fastosum Kossack, 1910 (Trematoda: Dicrocoeliidae)","volume":"200","author":"Basu AK","year":"2014","journal-title":"Vet Parasitol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.vetpar.2016.07.021","article-title":"Prevalence of Platynosomum fastosum infection in free roaming cats in northeastern Brazil: fluke burden and grading of lesions","volume":"227","author":"Braga RR","year":"2016","journal-title":"Vet Parasitol"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2307\/3284227","article-title":"Parasitology meets ecology on its own terms: Margolis et al. revisited","volume":"83","author":"Bush AO","year":"1997","journal-title":"J Parasitol"},{"issue":"S1","key":"ref8","first-page":"184","article-title":"Feline cholangitis\/cholangiohepatitis complex secondary to Platynosomum fastosum infection in a cat","volume":"17","author":"Carreira VS","year":"2008","journal-title":"Rev Bras Parasitol Vet"},{"key":"ref9","series-title":"Feline Medicine and Surgery (Flukes by Renaux, E.A.)","author":"Catcott EJ","year":"1964"},{"issue":"2","key":"ref10","first-page":"19","article-title":"Liver fluke infection (Platynosomum concinnum) in Brazilian cats: prevalence and pathology","volume":"27","author":"Ferreira AMR","year":"1999","journal-title":"Feline Pract"},{"issue":"10","key":"ref11","first-page":"1271","article-title":"Platynosomum concinnum infection in cats","volume":"16","author":"Foley RH","year":"1994","journal-title":"Compend Contin Educ Pract Vet"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"234","DOI":"10.5326\/0420234","article-title":"Severe cholestatic liver disease secondary to liver fluke (Platynosomum concinnum) infection in three cats","volume":"42","author":"Haney DR","year":"2006","journal-title":"J Am Anim Hosp Assoc"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1017\/S0022149X11000265","article-title":"Platynosomum fastosum- induced chronic intrahepatic cholangitis and Spirometra spp. infections in feral cats from Grand Cayman","volume":"86","author":"Headley SA","year":"2012","journal-title":"J Helminthol"},{"issue":"24","key":"ref14","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1136\/vr.89.24.635","article-title":"Platynosomum concinnum infection in cats in Nigeria","volume":"89","author":"Ikede BO","year":"1971","journal-title":"Vet Rec"},{"key":"ref15","series-title":"Essentials of veterinary hematology","author":"Jain NC","year":"1993"},{"key":"ref16","series-title":"Rev Colom Cienc Pecua","first-page":"659","volume-title":"First case of platinosomosis from Colombia: Platynosomum illiciens (Digenea: Dicrocoeliidae) in Felis catus, Turbo, Antioquia","volume":"22","author":"Lenis C","year":"2009"},{"issue":"1","key":"ref17","first-page":"17","article-title":"The life history and biology of Platynosomum fastosum Kossak, 1910 (Trematoda, Dicrocoeliidae)","volume":"21","author":"Maldonado JF","year":"1945","journal-title":"PR J Public Health Trop Med"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1751-0813.1976.tb00077.x","article-title":"Concurrent infection with Yersinia pseudotuberculosis and Platynosomum fastosum in a cat","volume":"52","author":"O\u2019Sullivan BM","year":"1976","journal-title":"Aust Vet J"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1007\/s00436-014-3926-5","article-title":"New insights into the life cycle of Platynosomum (Trematoda: Dicrocoeliidae)","volume":"113","author":"Pinto HA","year":"2014","journal-title":"Parasitol Res"},{"key":"ref20","series-title":"AFIP Laboratory Methods in Histotechnology","author":"Prophet EB","year":"1992"},{"key":"ref21","series-title":"R: a language and environment for statistical computing, reference index version 2.14.0","year":"2011"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1590\/S1984-29612013000200040","article-title":"Survey of helminth parasites of cats from the metropolitan area of Cuiab\u00e1, Mato Grosso, Brazil","volume":"22","author":"Ramos DGS","year":"2013","journal-title":"Rev Bras Parasitol Vet"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1136\/vr.88.3.62","article-title":"The liver-fluke Platynosomum fastosum in domestic cats","volume":"88","author":"Retnasabapathy A","year":"1971","journal-title":"Vet Rec"},{"issue":"22","key":"ref24","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1136\/vr.154.22.693","article-title":"Prevalence, abundance and risk factors of liver fluke (Platynosomum fastosum) infection in cats in Mexico","volume":"154","author":"Rodriguez-Vivas RI","year":"2004","journal-title":"Vet Rec"},{"issue":"3","key":"ref25","first-page":"271","article-title":"Ultrasonography in hepatobiliary evaluation of domestic cats (Felis catus, L., 1758) infected by Platynosomum Looss, 1907","volume":"3","author":"Salom\u00e3o M","year":"2005","journal-title":"Intern J Appl Res Vet Med"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1017\/S0022149X07214117","article-title":"Toxocara cati infections in stray cats in northern Iran","volume":"81","author":"Sharif M","year":"2007","journal-title":"J Helminthol"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/S0020-7519(97)00120-3","article-title":"Immunological approaches for the control of fasciolosis","volume":"27","author":"Spithill TW","year":"1997","journal-title":"Int J Parasitol"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2460\/ajvr.1977.38.01.51","article-title":"Experimental infection of cats with the liver fluke Platynosomum concinnum.","volume":"38","author":"Taylor D","year":"1977","journal-title":"Am J Vet Res"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jfms.2006.08.006","article-title":"Cystic liver disease related to high Platynosomum fastosum infection in a domestic cat","volume":"9","author":"Xavier FG","year":"2007","journal-title":"J Feline Med Surg"}],"container-title":["Revista Brasileira de Parasitologia Veterin\u00e1ria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rbpv\/v26n1\/1984-2961-rbpv-S1984-29612017009.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T23:14:02Z","timestamp":1750115642000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1984-29612017000100054&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,16]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,3]]}},"alternative-id":["S1984-29612017000100054"],"URL":"https:\/\/doi.org\/10.1590\/s1984-29612017009","relation":{},"ISSN":["1984-2961","0103-846X"],"issn-type":[{"value":"1984-2961","type":"electronic"},{"value":"0103-846X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3,16]]}}}