{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T09:47:00Z","timestamp":1719481620089},"reference-count":21,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Bras. Parasitol. Vet."],"abstract":"<jats:p>Abstract Cyathostomins are the most prevalent nematodes of horses, and multidrug resistance has been reported worldwide. There is a need to implement alternative drug monitoring analytical tests. The objective of this study was to determine the consistency (5 repetitions) of the larval migration on agar test (LMAT) using ivermectin, moxidectin, pyrantel or albendazole against cyathostomin infective-stage larvae in eight different concentrations. LMAT showed a strong coefficient of determination (R2 &gt; 0.91), between the test repetitions (n=5). The average 50% effective concentration (EC50) for ivermectin, moxidectin, pyrantel and albendazole were 0.0404, 0.0558, 0.0864 and 0.0988 nMol, respectively. The results of the EC50 for albendazole showed the greatest range of concentration. Ivermectin and moxidectin had the lowest in between-test variation. In the future, internationally certified susceptible isolates could be used for screening new drug candidates, or to follow up the pattern of drug efficacy from field populations.<\/jats:p>","DOI":"10.1590\/s1984-29612017055","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T22:44:55Z","timestamp":1510181095000},"page":"90-93","source":"Crossref","is-referenced-by-count":1,"title":["In vitro evaluation of ivermectin, moxidectin, albendazole and pyrantel against cyathostomins of horses"],"prefix":"10.1590","volume":"27","author":[{"given":"Marcelo Beltr\u00e3o","family":"Molento","sequence":"first","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brasil; Instituto Nacional de Ci\u00eancia e Tecnologia Gen\u00e9tico-Sanit\u00e1ria da Pecu\u00e1ria Brasileira,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Jos\u00e9","family":"Canever","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2017,11,9]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.vetpar.2012.12.020","article-title":"Lack of Cyathostomin sp. reduction after anthelmintic treatment in horses in Brazil","volume":"194","author":"Canever RJ","year":"2013","journal-title":"Vet Parasitol"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0304-4017(99)00113-2","article-title":"A comparison of in vitro tests and a faecal egg count reduction test in detecting anthelmintic resistance in horse strongyles","volume":"85","author":"Craven J","year":"1999","journal-title":"Vet Parasitol"},{"issue":"1-2","key":"ref3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.vetpar.2010.08.020","article-title":"Standardization of the larval migration inhibition test for the detection of 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