{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:07:23Z","timestamp":1787828843481,"version":"build-2784847793"},"reference-count":37,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Bras. Parasitol. Vet."],"abstract":"<jats:p>Abstract Coxiella burnetii is a zoonotic agent transmitted mainly by small ruminants. In Brazil the disease has been classified as a notifiable disease since 2013, when human cases were reported. This study aimed to identify risk factors associated with the presence of anti- Coxiella burnetii antibodies in goats and sheep in a semiarid region of Northeastern Brazil. Sera of 412 goats and 403 sheep from municipality of Petrolina, Pernambuco, were examined by the Indirect Fluorescent Antibody Test (IFAT) against antigens of C. burnetii. Information about management variables (independent variables) that could be associated with the presence of the microorganism (dependent variables) were obtained from the supervisor of each farm. It was determined that 2.2% (9\/412) of the goats and 2.1% (9\/403) of the sheep had antibodies reactive to C. burnetii. The presence of anti-C. burnetii antibodies was associated with the dry area of the Sequeiro (a region in the northern part of the municipality of Petrolina) (P = 0.025), male sheep (P = 0.020), and intensive goat breeding (P = 0.005). This study therefore showed the presence of anti-C. burnetii antibodies in goat and sheep, confirming for the first time that this agent is likely circulating among goat herds in the Caatinga Biome, semi-arid of Brazil.<\/jats:p>","DOI":"10.1590\/s1984-296120180086","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T17:14:36Z","timestamp":1543943676000},"page":"514-520","source":"Crossref","is-referenced-by-count":24,"title":["Serological diagnosis and risk factors for Coxiella burnetii in goats and sheep in a semi-arid region of Northeastern Brazil"],"prefix":"10.1590","volume":"27","author":[{"given":"Eline Almeida Rodrigues de","family":"Souza","sequence":"first","affiliation":[{"name":"Universidade Federal do Vale do S\u00e3o Francisco,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine Monalize Serafim de","family":"Castro","sequence":"additional","affiliation":[{"name":"Universidade Federal do Vale do S\u00e3o Francisco,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glauber Meneses Barboza de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Vale do S\u00e3o Francisco,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio Santos","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Universidade Federal de Campina Grande,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo de Moraes","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Instituto Federal de Educa\u00e7\u00e3o, Ci\u00eancia e Tecnologia,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Bahia","family":"Labruna","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio Claudio","family":"Horta","sequence":"additional","affiliation":[{"name":"Universidade Federal do Vale do S\u00e3o Francisco,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2018,12]]},"reference":[{"issue":"1","key":"ref1","first-page":"131","article-title":"Perfil sanit\u00e1rio dos rebanhos caprinos e ovinos no sert\u00e3o de Pernambuco","volume":"11","author":"Alencar SPA","year":"2010","journal-title":"Cienc Anim Bras"},{"issue":"3-4","key":"ref2","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.vetmic.2013.08.004","article-title":"Serological evidence of exposure to Coxiella burnetii in sheep and goats in central Portugal","volume":"167","author":"Anast\u00e1cio S","year":"2013","journal-title":"Vet Microbiol"},{"issue":"3-4","key":"ref3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.vetmic.2009.07.016","article-title":"Q fever","volume":"140","author":"Angelakis E","year":"2010","journal-title":"Vet Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.prevetmed.2016.01.026","article-title":"A cross sectional study evaluating the prevalence of Coxiella burnetii , potential risk factors for infection, and agreement between diagnostic methods in goats in Indiana","volume":"126","author":"Bauer AE","year":"2016","journal-title":"Prev Vet Med"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.11606\/issn.2358-792X.v7i1p127-131","article-title":"Investiga\u00e7\u00f5es sobre a febre \u201cQ\u201d em S\u00e3o Paulo \u2013 I \u2013 Estudo sorol\u00f3gico em oper\u00e1rios de um frigor\u00edfico","volume":"7","author":"Brand\u00e3o H","year":"1953","journal-title":"Arq Fac Hig S Pub Univ Sao Paulo"},{"key":"ref6","article-title":"Instru\u00e7\u00e3o Normativa n\u00b0 50 de 24 de setembro de 2013","year":"2013","journal-title":"Di\u00e1rio Oficial da Rep\u00fablica Federativa do Brasil"},{"issue":"8","key":"ref7","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1590\/S0074-02762005000800006","article-title":"Antibodies to Rickettsia rickettsii, Rickettsia typhi, Coxiella burnetii, Bartonella henselae, Bartonella quintana, and Ehrlichia chaffeensis among healthy population in Minas Gerais, Brazil","volume":"100","author":"Costa PSG","year":"2005","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1590\/S0036-46652006000100002","article-title":"Questing one brazilian query: reporting 16 cases of Q fever from Minas Gerais, Brazil","volume":"48","author":"Costa PSG","year":"2006","journal-title":"Rev Inst Med Trop S\u00e3o Paulo"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0167-5877(96)01074-4","article-title":"An overview of techniques for dealing with large numbers of independent variables in epidemiologic studies","volume":"29","author":"Dohoo IR","year":"1997","journal-title":"Prev Vet Med"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1128\/CMR.00045-16","article-title":"From Q Fever to Coxiella burnetii Infection: a Paradigm Change","volume":"30","author":"Eldin C","year":"2017","journal-title":"Clin Microbiol Rev"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1590\/s0100-736x2017000600004","article-title":"Investiga\u00e7\u00e3o sorol\u00f3gica de Rickettsia rickettsii e Coxiella burnetii em caprinos e ovinos no entorno do Parque Nacional da Serra das Confus\u00f5es, Piau\u00ed","volume":"37","author":"Guimar\u00e3es MF","year":"2017","journal-title":"Pesq Vet Bras"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"e96607","DOI":"10.1371\/journal.pone.0096607","article-title":"Land-Applied goat manure as a source of human Q-Fever in the Netherlands, 2006-2010","volume":"9","author":"Hermans T","year":"2014","journal-title":"PLoS One"},{"key":"ref13","series-title":"Applied Logistic Regression. Second Edition","author":"Hosmer DW","year":"2000"},{"key":"ref14","series-title":"Panorama da Pecu\u00e1ria Nacional","year":"2015"},{"issue":"1-2","key":"ref15","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.vetmic.2014.06.029","article-title":"Molecular and serologic detection of Coxiella burnetii in native Korean goats (Capra hircus coreanae)","volume":"173","author":"Jung BY","year":"2014","journal-title":"Vet Microbiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1469-0691.2008.02144.x","article-title":"Seroprevalence of Coxiella burnetii antibodies in human immunodeficiency virus-positive patients in Jacarepagu\u00e1, Rio de Janeiro, Brazil","volume":"15","author":"Lamas CC","year":"2009","journal-title":"Clin Microbiol Infect"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijid.2012.10.009","article-title":"Bartonella and Coxiella infective endocarditis in Brazil: molecular evidence from excised valves from a cardiac surgery referral center in Rio de Janeiro, Brazil, 1998 to 2009","volume":"17","author":"Lamas CC","year":"2013","journal-title":"Int J Infect Dis"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1089\/vbz.2009.0261","article-title":"Q Fever as a cause of fever of unknown origin and thrombocytosis: First Molecular evidence of Coxiella burnetii in Brazil","volume":"11","author":"Lemos ERS","year":"2011","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4269\/ajtmh.17-0979","article-title":"Q Fever in military firefighters during cadet training in Brazil","volume":"99","author":"Lemos ERS","year":"2018","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1590\/0037-8682-0076-2013","article-title":"Molecular identification of the agent of Q fever \u2013 Coxiella burnetii \u2013 in domestic animals in State of Rio de Janeiro, Brazil","volume":"47","author":"Mares-Guia MAMM","year":"2014","journal-title":"Rev Soc Bras Med Trop"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.4269\/ajtmh.15-0575","article-title":"Molecular identification of Q Fever in patients with a suspected diagnosis of Dengue in Brazil in 2013\u20132014","volume":"94","author":"Mares-Guia MAMM","year":"2016","journal-title":"Am J Trop Med Hyg"},{"issue":"1-2","key":"ref22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.prevetmed.2015.07.007","article-title":"Coxiella burnetii seropositivity and associated risk factors in sheep in Ontario, Canada","volume":"122","author":"Meadows S","year":"2015","journal-title":"Prev Vet Med"},{"issue":"3-4","key":"ref23","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.prevetmed.2015.06.014","article-title":"Coxiella burnetii seropositivity and associated risk factors in goats in Ontario, Canada","volume":"121","author":"Meadows S","year":"2015","journal-title":"Prev Vet Med"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/zph.12342","article-title":"Seroprevalence and factors associated with Coxiella burnetii infection in small ruminants in Baringo County, Kenya","volume":"64","author":"Muema J","year":"2017","journal-title":"Zoonoses Public Health"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.actatropica.2018.04.010","article-title":"Coxiella burnetii in dairy goats with a history of reproductive disorders in Brazil","volume":"183","author":"Oliveira JMB","year":"2018","journal-title":"Acta Trop"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3201\/eid1902.120362","article-title":"Coxiella burnetii in ticks, Argentina","volume":"19","author":"Pacheco RC","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"ref27","first-page":"18","article-title":"Estudo de casos de aborto em caprinos e ovinos no estado de Pernambuco, Brasil","volume":"16","author":"Pereira MF","year":"2013","journal-title":"Ci\u00eanc Vet Tr\u00f3p"},{"issue":"3-4","key":"ref28","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10493-006-9012-7","article-title":"Borrelia, Coxiella and Rickettsia in Carios capensis (Acari: Argasidae) from a brown pelican (Pelecanus occidentalis) rookery in South Carolina, USA","volume":"39","author":"Reeves WK","year":"2006","journal-title":"Exp Appl Acarol"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/oxfordjournals.aje.a112028","article-title":"Antibodies to Toxoplasma gondii and Coxiella burnetii among students and other personnel in veterinary colleges in California and Brazil","volume":"100","author":"Riemann HP","year":"1974","journal-title":"Am J Epidemiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.prevetmed.2016.05.014","article-title":"Q fever seroprevalence and risk factors in sheep and goats in northwest Italy","volume":"130","author":"Rizzo F","year":"2016","journal-title":"Prev Vet Med"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1590\/S0074-02762012000500021","article-title":"Coxiella burnetii, the agent of Q fever in Brazil: its hidden role in seronegative arthritis and the importance of molecular diagnosis based on the repetitive element IS1111 associated with the transposase gene","volume":"107","author":"Rozental T","year":"2012","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"81","key":"ref32","first-page":"1","article-title":"Seroprevalence and risk factors of Q fever in goats on commercial dairy goat farms in the Netherlands, 2009-2010","volume":"7","author":"Schimmer B","year":"2011","journal-title":"BMC Vet Res"},{"issue":"9","key":"ref33","doi-asserted-by":"crossref","first-page":"5455","DOI":"10.1073\/pnas.0931379100","article-title":"Complete genome sequence of the Q-fever pathogen Coxiella burnetii.","volume":"100","author":"Seshadri R","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"ref34","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.3201\/eid2108.140343","article-title":"Bartonella spp. and Coxiella burnetii associated with community-acquired, culture-negative endocarditis, Brazil","volume":"21","author":"Siciliano RF","year":"2015","journal-title":"Emerg Infect Dis"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1590\/S0037-86822008000400017","article-title":"Endocardite por Coxiella burnetii (febre Q). Doen\u00e7a rara ou pouco diagnosticada? Relato de caso","volume":"41","author":"Siciliano RF","year":"2008","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref36","series-title":"Veterinary Epidemiology. Third Edition","first-page":"228","volume-title":"Surveys","author":"Thrusfield M","year":"1995"},{"issue":"1-2","key":"ref37","doi-asserted-by":"crossref","first-page":"167","DOI":"10.11606\/issn.2358-792X.v9i1-2p167-180","article-title":"Investiga\u00e7\u00f5es sobre a febre Q em S\u00e3o Paulo \u2013 II \u2013 Estudo em tratadores de gado e em bovinos","volume":"9","author":"Valle LAR","year":"1955","journal-title":"Arq Fac Hig Saude Publica Univ Sao Paulo"}],"container-title":["Revista Brasileira de Parasitologia Veterin\u00e1ria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rbpv\/v27n4\/1984-2961-rbpv-27-4-514.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T23:23:21Z","timestamp":1545434601000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1984-29612018000400514&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":37,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["S1984-29612018000400514"],"URL":"https:\/\/doi.org\/10.1590\/s1984-296120180086","relation":{},"ISSN":["1984-2961","0103-846X"],"issn-type":[{"value":"1984-2961","type":"electronic"},{"value":"0103-846X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]}}}