{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T07:00:56Z","timestamp":1777964456912,"version":"3.51.4"},"reference-count":44,"publisher":"FapUNIFESP (SciELO)","issue":"4","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Bras. Parasitol. Vet."],"abstract":"<jats:p>Abstract Eimeriosis is a global poultry health problem. In the current study, we investigated the role of Salvadora persica leaf extracts (SE) against murine eimeriosis induced by Eimeria papillata. The infection induced an oocyst output of 6242 \u00b1 731 oocysts\/g feces. After treatment with 300 mg\u2044kg SE, the oocysts expelled in feces decreased by approximately 3-fold. In addition, the total number of E. papillata in the parasitic stage decreased in the jejunum of mice after treatment with SE. In addition, SE significantly reduced the number of apoptotic cells by approximately 2-fold in the infected jejunum. SE ameliorated the changes in glutathione, malondialdehyde, and catalase due to E. papillata infection. Finally, SE regulated the cytokine genes, interleukin (IL)-1\u03b2, IL-6, interferon-\u03b3, and tumor necrosis factor-\u03b1, and the apoptotic genes, B-cell lymphoma-2, Bax, and Caspase-3. SE protects the jejunum from E. papillata induced injury and may have potential therapeutic value as a food additive during eimeriosis.<\/jats:p>","DOI":"10.1590\/s1984-29612019068","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T19:30:34Z","timestamp":1573068634000},"page":"605-612","source":"Crossref","is-referenced-by-count":18,"title":["Salvadora persica protects mouse intestine from eimeriosis"],"prefix":"10.1590","volume":"28","author":[{"given":"Saleh","family":"Al-Quraishy","sequence":"first","affiliation":[{"name":"King Saud University,  Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felwa Abdullah","family":"Thagfan","sequence":"additional","affiliation":[{"name":"King Saud University,  Saudi Arabia; Princess Nourah bint Abdulrahman University,  Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esam Mohamed","family":"Al-Shaebi","sequence":"additional","affiliation":[{"name":"King Saud University,  Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmood","family":"Qasem","sequence":"additional","affiliation":[{"name":"King Saud University,  Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rewaida","family":"Abdel-Gaber","sequence":"additional","affiliation":[{"name":"King Saud University,  Saudi Arabia; Cairo University,  Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1869-5800","authenticated-orcid":false,"given":"Mohamed Abdel Monam","family":"Dkhil","sequence":"additional","affiliation":[{"name":"King Saud University,  Saudi Arabia; Helwan University,  Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2019,12]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"830","DOI":"10.2174\/18715273113129990081","article-title":"The neuroprotective effects of purslane (Portulaca oleracea) on rotenone-induced biochemical changes and apoptosis in brain of rat","volume":"12","author":"Abdel Moneim AE","year":"2013","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"9","key":"ref2","first-page":"2343","article-title":"Anthelmintic activity of Salvadora persica root extract against Pheretima posthuma.","volume":"2","author":"Abdul Majeed S","year":"2011","journal-title":"Int J Pharm Sci Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro.","volume":"105","author":"Aebi H","year":"1984","journal-title":"Methods Enzymol"},{"issue":"04","key":"ref4","first-page":"129","article-title":"Biological activities of Salvadora persica L. 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