{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T05:07:24Z","timestamp":1768194444844,"version":"3.49.0"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"4","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Bras. Parasitol. Vet."],"abstract":"<jats:p>Abstract Schistosomiasis is a neglected disease that affects millions of people around the world, being common in the state of Maranh\u00e3o. A total of 225 rodents of the Holochilus sciureus species from the Western Lowland Maranh\u00e3o were studied, of which 144 animals (64%) exhibited Schistosoma eggs in their feces samples. Macroscopic lesions characterized as well-defined whitish areas on the liver and spleen surfaces were observed. Histopathological examination revealed multifocal granulomas in the esophagus, liver, spleen, pancreas and duodenum, with structures compatible with Schistosoma mansoni eggs, as well as severe hepatic micro-vacuolar degeneration, multifocal and coalescent, with proliferation of random bile ducts and associated epithelial hyperplasia to areas of fibrosis. Adult forms of the parasite were observed in the blood vessels of the portal space. The lungs exhibited moderate and diffuse interstitial pneumonia with intralesional S. mansoni eggs. In the kidneys, hyaline cylinders were observed in the pelvis and diffuse hemorrhage. In conclusion, H. sciureus displays a pathological picture similar to human being. This rodent plays a role as sentinel in Baixada Maranhense.<\/jats:p>","DOI":"10.1590\/s1984-29612019075","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T21:28:09Z","timestamp":1570829289000},"page":"769-772","source":"Crossref","is-referenced-by-count":5,"title":["Parasitological and histological aspects of Holochilus sciureus naturally infected by Schistosoma mansoni"],"prefix":"10.1590","volume":"28","author":[{"given":"N\u00eauton da","family":"Silva-Souza","sequence":"first","affiliation":[{"name":"Universidade Estadual do Maranh\u00e3o,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Patr\u00edcia de Carvalho da","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Tocantins,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Mondego de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranh\u00e3o,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Gabriela Sampaio","family":"Lira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranh\u00e3o,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranielly Ara\u00fajo","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranh\u00e3o,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiane Aranha da","family":"Penha-Silva","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Maranh\u00e3o,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solange de Ara\u00fajo","family":"Melo","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Maranh\u00e3o,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio Henrique Evangelista de","family":"Andrade","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Maranh\u00e3o,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa Sarmento dos","family":"Santos-Ribeiro","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Maranh\u00e3o,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alcina Vieira de","family":"Carvalho Neta","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Maranh\u00e3o,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2167-3725","authenticated-orcid":false,"given":"Ana Lucia","family":"Abreu-Silva","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Maranh\u00e3o,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2019,12]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184696","article-title":"Histological assessment of granulomas in natural and experimental Schistosoma mansoni infections using Whole slide imaging","volume":"12","author":"Amaral KB","year":"2017","journal-title":"PLoS One"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1590\/S0036-46651984000600004","article-title":"Holochilus sciureus nanus Thomas, 1897. 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