{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:51:17Z","timestamp":1768971077355,"version":"3.49.0"},"reference-count":34,"publisher":"FapUNIFESP (SciELO)","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Bras. Parasitol. Vet."],"abstract":"<jats:p>Abstract Leishmania infantum is a trypanosomatid that causes parasitic dermatopathy in dogs. Trypanosoma caninum is another trypanosomatid, which infects the skin of dogs, although cutaneous abnormalities are absent. This study aimed to investigate the occurrence of T. caninum infection and its associated cutaneous and histological changes and compare it with the occurrence of L. infantum infection in dogs. The study included 150 dogs, of which T. caninum infection was identified in 3 (2%) and L. infantum infection in 15 (10%) of them, with no association (p&gt;0.05) of these infections with the breed, gender, age, or cutaneous abnormalities. The cutaneous abnormalities were based on 1 (4.8%) and 12 (57.1%) dogs infected by T. caninum and L. infantum, respectively. The dermatohistopathological abnormalities in the dogs infected with T. caninum included mild perivascular lymphohistioplasmacytic infiltrates in the clinically asymptomatic ones, while in those with dermatological abnormalities, acanthosis, epidermal orthokeratotic hyperkeratosis, melanomacrophages, and co-infection with Microsporum sp. and Trichophyton sp. were observed. InL. infantum infected, the histopathological findings included chronic granulomatous inflammatory infiltrates and structures compatible with amastigotes. Despite the low frequency of T. caninum infection, our findings suggest that this trypanosomatid, unlike L. infantum, does not cause any macroscopic skin abnormalities.<\/jats:p>","DOI":"10.1590\/s1984-29612019100","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:58:43Z","timestamp":1581469123000},"source":"Crossref","is-referenced-by-count":4,"title":["Clinical-dermatological, histological abnormalities and prevalence of Trypanosoma caninum and Leishmania infantum in dogs from Midwest region of Brazil"],"prefix":"10.1590","volume":"29","author":[{"given":"Herica","family":"Makino","sequence":"first","affiliation":[{"name":"Universidade Federal de Mato Grosso,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janaina Marcela Assun\u00e7\u00e3o Rosa","family":"Moreira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalinne Stephanie","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Atsumy Funakawa","family":"Otsubo","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliano","family":"Bortolini","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria R\u00e9gia Franco","family":"Sousa","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Dutra","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edson Moleta","family":"Colodel","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Nakazato","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6694-1407","authenticated-orcid":false,"given":"Arleana do Bom Parto Ferreira de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1590\/S0037-86822009000200012","article-title":"Inqu\u00e9rito soroepidemiol\u00f3gico de leishmaniose canina em \u00e1reas end\u00eamicas de Cuiab\u00e1, Estado de Mato Grosso","volume":"42","author":"Almeida ABPF","year":"2009","journal-title":"Rev Soc Bras Med Trop"},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1590\/S0103-84782010005000102","article-title":"Preval\u00eancia e epidemiologia da leishmaniose visceral em c\u00e3es e humanos, na cidade de Cuiab\u00e1, Mato Grosso, Brasil","volume":"40","author":"Almeida ABPF","year":"2010","journal-title":"Cienc Rural"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1089\/vbz.2011.0723","article-title":"Use of parasitological culture to detect Leishmania (Leishmania) chagasi in naturally infected dogs","volume":"11","author":"Almeida ABPF","year":"2011","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.diagmicrobio.2013.03.017","article-title":"Canine visceral leishmaniasis: diagnostic approaches based on polymerase chain reaction employing different biological samples","volume":"76","author":"Almeida ABPF","year":"2013","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.rvsc.2012.07.006","article-title":"Evaluation of serological cross-reactivity between canine visceral leishmaniasis and natural infection by Trypanosoma caninum.","volume":"93","author":"Alves AS","year":"2012","journal-title":"Res Vet Sci"},{"issue":"7","key":"ref6","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.pt.2008.04.001","article-title":"Canine leishmaniosis - new concepts and insights on an expanding zoonosis: part one","volume":"24","author":"Baneth G","year":"2008","journal-title":"Trends Parasitol"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.trstmh.2012.03.014","article-title":"Occurrence of Trypanosoma caninum in areas overlapping with leishmaniasis in Brazil: what is the real impact of canine leishmaniasis control?","volume":"106","author":"Barros JHS","year":"2012","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.clindermatol.2009.12.012","article-title":"Superficial veterinary mycoses","volume":"28","author":"Bond R","year":"2010","journal-title":"Clin Dermatol"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.exppara.2009.10.005","article-title":"Leishmania (Leishmania) infantum\/chagasi: histopathological aspects of the skin in naturally infected dogs in two endemic areas","volume":"124","author":"Calabrese KS","year":"2010","journal-title":"Exp Parasitol"},{"issue":"7","key":"ref10","first-page":"877","article-title":"Histopathological and parasitological investigations of ear healthy skin of dogs naturally and experimentally infected with Leishmania (Leishmania) chagasi.","volume":"25","author":"Figueiredo MM","year":"2010","journal-title":"Histol Histopathol"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1590\/S0100-736X2013000300014","article-title":"Preval\u00eancia das doen\u00e7as de pele n\u00e3o neopl\u00e1sicas em c\u00e3es no munic\u00edpio de Cuiab\u00e1, Mato Grosso","volume":"33","author":"Gasparetto ND","year":"2013","journal-title":"Pesq Vet Bras"},{"key":"ref12","series-title":"The trypanosomes of mammals: a zoological monograph","first-page":"671","volume-title":"Skin and appendages","author":"Ginn PE","year":"1972"},{"key":"ref13","series-title":"Skin diseases of the dog and cat: clinical and histopathologic diagnosis","author":"Gross TL","year":"2005","edition":"2nd"},{"key":"ref14","series-title":"Pathologic basis of veterinary disease","first-page":"1107","volume-title":"The integument","author":"Hargis AM","year":"2007","edition":"4th"},{"key":"ref15","series-title":"The trypanosomes of mammals: a zoological monograph","first-page":"288","volume-title":"Herpetosoma from man and other mammals","author":"Hoare CA","year":"1972"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1128\/JCM.40.1.210-215.2002","article-title":"Comparison of six PCR methods using peripheral blood for detection on canine visceral leishmaniasis","volume":"40","author":"Lachaud L","year":"2002","journal-title":"J Clin Microbiol"},{"issue":"3-4","key":"ref17","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.vetpar.2006.01.059","article-title":"Post mortem parasitological evaluation of dogs seroreactive for Leishmania from Rio de Janeiro, Brazil","volume":"138","author":"Madeira M","year":"2006","journal-title":"Vet Parasitol"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1645\/13-297.1","article-title":"Trypanosoma caninum, a new parasite described in dogs in Brazil: aspects of natural infection","volume":"100","author":"Madeira MF","year":"2014","journal-title":"J Parasitol"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1017\/S003118200900554X","article-title":"Trypanosoma caninum n. sp. (Protozoa: Kinetoplastida) isolated from intact skin of a domestic dog (Canis familiaris) captured in Rio de Janeiro, Brazil","volume":"136","author":"Madeira MF","year":"2009","journal-title":"Parasitology"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"40","DOI":"10.5380\/avs.v19i2.32998","article-title":"Presen\u00e7a de fungos com potencial patog\u00eanico em instrumentos de tosa","volume":"19","author":"Mattei AS","year":"2014","journal-title":"Arch Vet Sci"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1590\/S0036-46652011000200007","article-title":"Dermatophytoses in domesticated animals","volume":"53","author":"Nweze EI","year":"2011","journal-title":"Rev Inst Med Trop S\u00e3o Paulo"},{"issue":"46","key":"ref22","doi-asserted-by":"crossref","first-page":"6432","DOI":"10.5897\/AJB2013.12093","article-title":"A review on trypanosomiasis in dogs and cats","volume":"12","author":"Nwoha RIO","year":"2013","journal-title":"Afr J Biotechnol"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1590\/S0037-86822010000400013","article-title":"Seroprevalence and risk factors for canine visceral leishmaniasis in the endemic area of Dias D\u2019\u00c1vila, State of Bahia, Brazil","volume":"43","author":"Oliveira LCP","year":"2010","journal-title":"Rev Soc Bras Med Trop"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1590\/0037-8682-0307-2014","article-title":"Report of new cases of Trypanosoma caninum in Brazil","volume":"48","author":"Oliveira TS","year":"2015","journal-title":"Rev Soc Bras Med Trop"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1590\/1678-6869","article-title":"Skin impression with acetate tape in Demodex canis and Sarcoptes scabiei var. vulpes diagnosis","volume":"67","author":"Pereira DT","year":"2015","journal-title":"Arq Bras Med Vet Zootec"},{"issue":"1-2","key":"ref26","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.vetpar.2014.07.028","article-title":"Evaluation of 18S rDNA PCR assay using skin fragments as a diagnostic test for Trypanosoma caninum.","volume":"205","author":"Pinto AGS","year":"2014","journal-title":"Vet Parasitol"},{"key":"ref27","series-title":"Laboratory methods in histotechnology","author":"Prophet EB","year":"1992"},{"issue":"1-2","key":"ref28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetpar.2010.12.033","article-title":"Detection of Leishmania (L.) chagasi in canine skin","volume":"178","author":"Queiroz NMGP","year":"2011","journal-title":"Vet Parasitol"},{"key":"ref29","series-title":"Molecular cloning a laboratory manual","author":"Sambrook J","year":"2001","edition":"3rd"},{"key":"ref30","series-title":"Muller and Kirk\u2019s: small animal dermatology","author":"Scott DW","year":"2001","edition":"6th"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1590\/0074-02760160305","article-title":"Scoring clinical signs can help diagnose canine visceral leishmaniasis in a highly endemic area in Brazil","volume":"112","author":"Silva KR","year":"2017","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"11","key":"ref32","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1017\/S0031182008004824","article-title":"Trypanosomes in a declining species of threatened Australian marsupial, the brush-tailed Bettongia penicillata (Marsupialia: potoroidae)","volume":"135","author":"Smith A","year":"2008","journal-title":"Parasitology"},{"issue":"1-2","key":"ref33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetpar.2009.05.022","article-title":"Directions for the diagnosis, clinical staging, treatment and prevention of canine leishmaniosis","volume":"165","author":"Solano-Gallego L","year":"2009","journal-title":"Vet Parasitol"},{"issue":"3","key":"ref34","first-page":"667","article-title":"Padr\u00f5es histopatol\u00f3gicos das les\u00f5es descamativas e ulcerativas da pele em c\u00e3es com leishmaniose","volume":"29","author":"Torres No R","year":"2008","journal-title":"Semina: Ci\u00eanc Agr\u00e1r"}],"container-title":["Revista Brasileira de Parasitologia Veterin\u00e1ria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rbpv\/v29n1\/1984-2961-rbpv-29-1-e016319.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T18:29:30Z","timestamp":1611426570000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1984-29612020000100302&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020]]}},"alternative-id":["S1984-29612020000100302"],"URL":"https:\/\/doi.org\/10.1590\/s1984-29612019100","relation":{},"ISSN":["1984-2961","0103-846X"],"issn-type":[{"value":"1984-2961","type":"electronic"},{"value":"0103-846X","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"article-number":"e016319"}}