{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:08:02Z","timestamp":1771661282748,"version":"3.50.1"},"reference-count":57,"publisher":"FapUNIFESP (SciELO)","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Bras. Parasitol. Vet."],"abstract":"<jats:p>Abstract The consumption of inadequately thermally treated fish is a public health risk due to the possible propagation of Anisakis larvae. The present study demonstrated the physiological and histopathological changes that accompanied an oral inoculation of crude extracts from fresh and thermally treated Anisakis Type II (L3) in rats. Worms were isolated from a marine fish and examined and identified using light and scanning electron microscopy. The study was performed in 6 rat groups: control (I), garlic oil (GO) inoculated (II), fresh L3 inoculated (III), thermally treated L3 inoculated (IV), fresh L3 + GO inoculated (V), and a thermally treated L3 + GO inoculated (VI) groups. Rats inoculated with fresh and thermally treated L3 showed abnormal liver and kidney functions associated with the destruction of normal architecture. GO produced a protective effect in rat groups inoculated with L3 extracts + GO via the amelioration of liver and kidney functions, which was confirmed by the marked normal structure on histology. Cooking of L3-infected fish induced severe alterations compared to uncooked fish. The administration of garlic before and after fish eating is recommended to avoid the dangerous effect of anisakids, even if they are cooked.<\/jats:p>","DOI":"10.1590\/s1984-296120201086","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T14:20:26Z","timestamp":1613312426000},"source":"Crossref","is-referenced-by-count":1,"title":["The oil of garlic, Allium sativum L. (Amaryllidaceae), as a potential protectant against Anisakis spp. Type II (L3) (Nematoda) infection in Wistar rats"],"prefix":"10.1590","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0661-8605","authenticated-orcid":false,"given":"Kareem","family":"Morsy","sequence":"first","affiliation":[{"name":"King Khalid University, Saudi Arabia; Cairo University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali AL","family":"Ghamdi","sequence":"additional","affiliation":[{"name":"Al Baha University, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saad Bin","family":"Dajem","sequence":"additional","affiliation":[{"name":"King Khalid University, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0109-530X","authenticated-orcid":false,"given":"Mashael","family":"Bin-Meferij","sequence":"additional","affiliation":[{"name":"Princess Nourah bint Abdulrahman University, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Alshehri","sequence":"additional","affiliation":[{"name":"King Khalid University, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attalla","family":"El-kott","sequence":"additional","affiliation":[{"name":"King Khalid University, Saudi Arabia; Damanhour University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Essam","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"King Khalid University, Saudi Arabia; National Organization for Research and Control of Biologicals, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atef","family":"Ali","sequence":"additional","affiliation":[{"name":"Cairo University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamida","family":"Hamdi","sequence":"additional","affiliation":[{"name":"Cairo University, Egypt; Taif University, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin","family":"Al-Doaiss","sequence":"additional","affiliation":[{"name":"King Khalid University, Saudi Arabia; Sana'a University, Republic of Yemen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Saber","sequence":"additional","affiliation":[{"name":"National Organization for Drug Control and Research, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2021]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.21608\/ejhm.2002.18854","article-title":"Protective effects of garlic oil against liver damage induced by combined administration of ethanol and carbon tetrachloride in rats","volume":"6","author":"Abdel-Naim AB","year":"2002","journal-title":"Egypt J Hosp Med"},{"issue":"1","key":"ref2","first-page":"184","article-title":"Oral inoculation of live or dead third-stage larvae of Anisakis simplex in rats suggests that only live larvae induce production of antibody specific to A. simplex.","volume":"59","author":"Abe N","year":"2014","journal-title":"Acta Parasitol"},{"key":"ref3","first-page":"955S","article-title":"Recent advances on the nutritional effects associated with the use of garlic as a supplement. 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