{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:23:29Z","timestamp":1762341809640,"version":"3.41.2"},"reference-count":41,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Bras. Parasitol. Vet."],"abstract":"<jats:p>Abstract The present study aimed to evaluate the changes in peripheral blood glucose concentrations induced by Schistosoma mansoni infection in Holochilus sciureus rodents, a wild reservoir of the parasite. Glucose concentration was measured in the plasma of blood samples using a colorimetric enzymatic test. Biological parameters and S. mansoni burden in each rodent were also verified and correlated with glucose concentrations. A total of 76 H. sciureus were captured, out of which 20 (26%) were infected with S. mansoni (n=13 males and n=7 females). Although the parasite burden was comparable between the sexes, blood glucose concentration was lower in infected males and almost unchanged in females. Furthermore, histopathological data revealed that male rodents had a greater hepatic granulomatous inflammatory reaction than females. In addition, we also confirmed that the weight and total length of the analyzed animals had no effect on glucose levels. Therefore, natural infection with S. mansoni in H. sciureus may have a lower impact on glycemic homeostasis in females, which will help us understand the role of these rodents as reservoirs of S. mansoni.<\/jats:p>","DOI":"10.1590\/s1984-29612022019","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T20:54:28Z","timestamp":1648500868000},"source":"Crossref","is-referenced-by-count":1,"title":["Alterations in blood glucose concentration in wild rodents, Holochilus sciureus, naturally infected with Schistosoma mansoni"],"prefix":"10.1590","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0920-4977","authenticated-orcid":false,"given":"Jo\u00e3o Gustavo Mendes","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brasil; Universidade Estadual do Maranh\u00e3o,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0380-2167","authenticated-orcid":false,"given":"Maria Gabriela Sampaio","family":"Lira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranh\u00e3o,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9470-0918","authenticated-orcid":false,"given":"Ranielly Ara\u00fajo","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranh\u00e3o,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9527-4009","authenticated-orcid":false,"given":"Gleycka Cristine Carvalho","family":"Gomes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranh\u00e3o,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4689-3863","authenticated-orcid":false,"given":"Irlla Correia Lima","family":"Lic\u00e1","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranh\u00e3o,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4194-7578","authenticated-orcid":false,"given":"Jeferson Kelvin Alves de Oliveira","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3763-2776","authenticated-orcid":false,"given":"Guilherme Silva","family":"Miranda","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brasil; Instituto Federal de Educa\u00e7\u00e3o, Ci\u00eancia e Tecnologia do Maranh\u00e3o,  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LG","year":"1968","edition":"3rd"},{"issue":"1","key":"ref26","first-page":"131","article-title":"Trophic relationships among four cricetid rodents in rice fields","volume":"41","author":"Martino AM","year":"1993","journal-title":"Rev Biol Trop"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41572-018-0013-8","article-title":"Schistosomiasis","volume":"4","author":"McManus DP","year":"2018","journal-title":"Nat Rev Dis Primers"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1515\/helm-2017-0013","article-title":"The wild water-rats and their relevance in the context of schistosomiasis mansoni in Brazil: what we know and recommendations for further research","volume":"54","author":"Miranda GS","year":"2017","journal-title":"Helminthologia"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4236\/ojas.2019.92015","article-title":"Schistosoma mansoni infection in 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