{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:25:24Z","timestamp":1777505124245,"version":"3.51.4"},"reference-count":18,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Bras. Parasitol. Vet."],"abstract":"<jats:p>Abstract The bacterium Rickettsia rickettsii is the etiological agent of Brazilian spotted fever (BSF), and its most important vector to humans in Brazil is the tick Amblyomma sculptum. Capybaras are the main hosts of A. sculptum in many BSF-endemic areas and are considered valuable sentinels for BSF surveillance. This study aimed to assess the persistence of anti-R. rickettsii antibodies for long periods in capybaras and their passive transfer to offspring. For this purpose, three adult capybaras previously exposed to multiple infections with R. rickettsii were followed up until 3.1 years after their last exposure. During the study, one female delivered five cubs, of which three survived. Blood samples were collected monthly from adults and infants, and serum samples were titrated by indirect immunofluorescence assay (IFA) to determine endpoint titers of anti-R. rickettsii antibodies. All three adults remained seroreactive to R. rickettsii with high endpoint titers until the end of the study. All infants were seroreactive to R. rickettsii after birth and remained seroreactive for one to four months. This study showed that exposure of capybaras to R. rickettsii-infected A. sculptum ticks elicits a persistent antibody response. In addition, there was evidence of passive transfer of R. rickettsii-reactive antibodies to offspring.<\/jats:p>","DOI":"10.1590\/s1984-29612022052","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T21:30:35Z","timestamp":1664314235000},"source":"Crossref","is-referenced-by-count":1,"title":["Long-term persistence of anti-Rickettsia rickettsii antibodies in capybaras, with passive transfer to offspring"],"prefix":"10.1590","volume":"31","author":[{"given":"Lina de Campos","family":"Binder","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Ram\u00edrez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil; Universidad Nacional de Colombia,  Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Carolina de Azevedo","family":"Serpa","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Pinter","sequence":"additional","affiliation":[{"name":"Instituto Pasteur,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celso Eduardo","family":"Souza","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9675-3132","authenticated-orcid":false,"given":"Marcelo Bahia","family":"Labruna","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2022]]},"reference":[{"issue":"39","key":"ref1","first-page":"21","article-title":"Manejo de capivaras em \u00e1reas com casos de febre maculosa brasileira","volume":"50","year":"2019","journal-title":"Bol Epidemiol"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/jme\/tjz141","article-title":"Rickettsia rickettsii (Rickettsiales: Rickettsiaceae) infecting Amblyomma sculptum (Acari: Ixodidae) ticks and capybaras in a Brazilian spotted fever-endemic area of Brazil","volume":"57","author":"Costa FB","year":"2020","journal-title":"J Med Entomol"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1590\/S1984-29612011000400009","article-title":"Rickettsia species infecting Amblyomma ticks from an area endemic for Brazilian spotted fever in Brazil","volume":"20","author":"Guedes E","year":"2011","journal-title":"Rev Bras Parasitol Vet"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/aja.1001290303","article-title":"Protein absorption and transport by the guinea pig visceral yolk sac placenta","volume":"129","author":"King BF","year":"1970","journal-title":"Am J Anat"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0022-5320(82)90003-X","article-title":"The role of coated vesicles in selective transfer across yolk sac epithelium","volume":"79","author":"King BF","year":"1982","journal-title":"J Ultrastruct Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1756-3305-7-7","article-title":"Rickettsial infection in Amblyomma cajennense ticks and capybaras (Hydrochoerus hydrochaeris) in a Brazilian spotted fever-endemic area","volume":"7","author":"Krawczak FS","year":"2014","journal-title":"Parasit Vectors"},{"key":"ref7","first-page":"82","article-title":"Isolation of Rickettsia rickettsii from the tick Amblyomma sculptum from a Brazilian spotted fever-endemic area in the Pampulha Lake region, southeastern Brazil","volume":"8","author":"Labruna MB","year":"2017","journal-title":"Vet Parasitol Reg Stud Reports"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/aja.1001090205","article-title":"The transfer of serum proteins from mother to young in the guinea pig. 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Prenatal rates and routes","volume":"109","author":"Leissring JC","year":"1961","journal-title":"Am J Anat"},{"issue":"9","key":"ref9","article-title":"Epidemiology of capybara-associated Brazilian spotted fever","volume":"13","author":"Luz HR","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1053\/plac.2002.0806","article-title":"Placentation in the capybara (Hydrochaerus hydrochaeris), agouti (Dasyprocta aguti) and paca (Agouti paca)","volume":"23","author":"Miglino MA","year":"2002","journal-title":"Placenta"},{"key":"ref11","series-title":"Capybara - Biology, use and conservation of an exceptional neotropical species.","first-page":"147-","volume-title":"Capybara demographic traits.","author":"Moreira JR","year":"2013"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1128\/CMR.00032-13","article-title":"Update on tick-borne rickettsioses around the world: a geographic approach","volume":"26","author":"Parola P","year":"2013","journal-title":"Clin Microbiol Rev"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005613","article-title":"Transmission dynamics and control of Rickettsia rickettsii in populations of Hydrochoerus hydrochaeris and Amblyomma sculptum.","volume":"11","author":"Polo G","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ttbdis.2020.101463","article-title":"Capybaras (Hydrochoerus hydrochaeris) as amplifying hosts of Rickettsia rickettsii to Amblyomma sculptum ticks: evaluation during primary and subsequent exposures to R. rickettsii infection","volume":"11","author":"Ram\u00edrez-Hern\u00e1ndez A","year":"2020","journal-title":"Ticks Tick Borne Dis"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/s41598-020-57607-5","article-title":"Clinical and serological evaluation of capybaras (Hydrochoerus hydrochaeris) successively exposed to an Amblyomma sculptum-derived strain of Rickettsia rickettsii.","volume":"10","author":"Ram\u00edrez-Hern\u00e1ndez A","year":"2020","journal-title":"Sci Rep"},{"key":"ref16","first-page":"92","article-title":"Resolu\u00e7\u00e3o Conjunta SMA\/SES N\u00ba 01, de 1\u00b0 de julho de 2016. Disp\u00f5e sobre a aprova\u00e7\u00e3o das \u201cDiretrizes t\u00e9cnicas para a vigil\u00e2ncia e controle da Febre Maculosa Brasileira no Estado de S\u00e3o Paulo - classifica\u00e7\u00e3o de \u00e1reas e medidas preconizadas\u201d, e d\u00e1 outras provid\u00eancias","year":"2016","journal-title":"Di\u00e1rio Oficial do Estado"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1590\/S0103-84782008000600031","article-title":"Serological identification of Rickettsia spp from the spotted fever group in capybaras in the region of Campinas - SP \u2013 Brazil","volume":"38","author":"Souza CE","year":"2008","journal-title":"Cienc Rural"},{"issue":"1-2","key":"ref18","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.vetpar.2008.12.010","article-title":"Experimental infection of capybaras Hydrochoerus hydrochaeris by Rickettsia rickettsii and evaluation of the transmission of the infection to ticks Amblyomma cajennense.","volume":"161","author":"Souza CE","year":"2009","journal-title":"Vet Parasitol"}],"container-title":["Revista Brasileira de Parasitologia Veterin\u00e1ria"],"original-title":["Persist\u00eancia de longa dura\u00e7\u00e3o de anticorpos anti-Rickettsia rickettsii em capivaras, com transfer\u00eancia passiva para a prole"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S1984-29612022000300405&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T21:30:46Z","timestamp":1664314246000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1984-29612022000300405&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022]]}},"alternative-id":["S1984-29612022000300405"],"URL":"https:\/\/doi.org\/10.1590\/s1984-29612022052","relation":{},"ISSN":["1984-2961","0103-846X"],"issn-type":[{"value":"1984-2961","type":"electronic"},{"value":"0103-846X","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"e009922"}}