{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T06:27:17Z","timestamp":1775024837254,"version":"3.50.1"},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Bras. Parasitol. Vet."],"abstract":"<jats:p>Abstract In endemic areas for canine visceral leishmaniasis (CVL), the occurrence of coinfection with other pathogens, such as Ehrlichia spp., has been associated with worsening of the clinical condition. The study aimed to evaluate the occurrence of histological changes in the myocardia of dogs naturally infected with Leishmania chagasi with or without coinfection with Ehrlichia spp.. We evaluated paraffin-embedded myocardial sections from 31 dogs, affected by either L. chagasi alone or coinfected with L. chagasi and Ehrlichia spp., to compare the extent and degree of cardiac damage. The blocks were divided into two groups. G1 (dogs infected only by L. chagasi) and G2 (dogs coinfected with L. chagasi and Ehrlichia spp.). The right atrium free wall, right ventricle free wall, left ventricle, and interventricular septum of all groups were evaluated. Cardiac alterations were observed in 41.93% (52\/124) of the fragments evaluated and inflammatory infiltrate was the most common pattern found. The G2 group showed a higher incidence of myocarditis, with 61.53% (32\/52), compared to the G1 group, in which 20 out of 72 cases (27.7%) exhibited histopathological changes (p &lt;0.05). These findings confirmed that coinfection can potentiate cardiac damage in dogs.<\/jats:p>","DOI":"10.1590\/s1984-29612024023","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T10:38:55Z","timestamp":1717151935000},"source":"Crossref","is-referenced-by-count":2,"title":["Ehrlichia spp. infection worsens cardiac damage in dogs with canine visceral leishmaniasis"],"prefix":"10.1590","volume":"33","author":[{"given":"Leticia Gomes","family":"Zanfagnini","sequence":"first","affiliation":[{"name":"Universidade Federal do Acre,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janildo Ludolf","family":"Reis Junior","sequence":"additional","affiliation":[{"name":"Universidade Federal de Juiz de Fora,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin\u00edcius Novaes","family":"Rocha","sequence":"additional","affiliation":[{"name":"Universidade Federal de Juiz de Fora,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soraia Figueiredo","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade Federal do Acre,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina Yukie","family":"Hitara","sequence":"additional","affiliation":[{"name":"Universidade Federal de Juiz de Fora,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Marcondes","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5080-7799","authenticated-orcid":false,"given":"Ac\u00e1cio Duarte","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Universidade Federal do Acre,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2024]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1590\/S0100-879X2009007500037","article-title":"Cardiac and pulmonary alterations in symptomatic and asymptomatic dogs infected naturally with Leishmania (Leishmania) chagasi.","volume":"43","author":"Alves GBB","year":"2010","journal-title":"Braz J Med Biol Res"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1590\/s1984-29612014081","article-title":"Pathology of dogs in Campo Grande, MS, Brazil naturally co-infected with Leishmania infantum and Ehrlichia canis.","volume":"23","author":"Andrade GB","year":"2014","journal-title":"Rev Bras Parasitol Vet"},{"key":"ref3","article-title":"Investigation of comorbidities in dogs with leishmaniosis due to Leishmania infantum.","volume":"39","author":"Apostolidis 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