{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:55:20Z","timestamp":1781520920673,"version":"3.54.1"},"reference-count":51,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["009\/2023"],"award-info":[{"award-number":["009\/2023"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Bras. Parasitol. Vet."],"abstract":"<jats:p>Abstract Gastrointestinal nematode (GIN) infections significantly impact the health of ruminants. The indiscriminate use of anthelmintics contributes to the selection of drug-resistant parasites. Compounds containing selenium (Se) and tellurium (Te) have emerged as promising alternatives. This study aimed to evaluate the anthelmintic activity of diphenyl diselenide (PhSe)2, phenylselenenyl chloride (4-Cl-PhSe)2, and ammonium trichloro (dioxoethylene-O,O\u2019) tellurate (AS-101) on eggs and larvae (L3) of GIN. The compounds were tested using egg-hatch and larval-migration inhibition tests. Additionally, the possible in vitro cytotoxic effects were evaluated using the AlamarBlue assay. (PhSe)2 exhibited the highest ovicidal effect, with a 50% inhibitory concentration (IC50) of 1.801 mmol L\u22121 for GIN isolated from sheep and 1.845 mmol L\u22121 for GIN from cattle. AS-101 showed the highest larvicidal activity, with IC50 values of 0.976 mmol L\u22121 for GIN of sheep and 1.035 mmol L\u22121 for GIN of cattle. Combinations of (PhSe)2 with ivermectin (IVM) showed a mild synergistic effect, with an additive interaction of 13.33%. Among the tested compounds, (PhSe)2 showed the lowest cytotoxicity in LLC-MK2 cells. Taken together, these data highlight the therapeutic potential of the novel molecules.<\/jats:p>","DOI":"10.1590\/s1984-29612026017","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:32:01Z","timestamp":1781519521000},"source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of selenium- and tellurium-based organocompounds against ruminant gastrointestinal nematodes in vitro"],"prefix":"10.1590","volume":"35","author":[{"given":"Taynara Gabriele Ribeiro","family":"Piano","sequence":"first","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irineu","family":"Romero Neto","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Piovan","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro Bittencourt de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alda L\u00facia Gomes","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tay","family":"Zugman","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo Ariel Schorr","family":"Zotz","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula Yaeko","family":"Yoshitani","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0572-5628","authenticated-orcid":false,"given":"Marcelo Beltr\u00e3o","family":"Molento","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"8","key":"ref1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1055\/s-1989-27344","article-title":"Synthesis and properties of ammonium trichloro(dioxyethylene-O,O\u2032) tellurate (AS-101). 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