{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:40:06Z","timestamp":1762641606572},"reference-count":22,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dental Press J. Orthod."],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>INTRODUCTION: The mandibular condylar surface is made up of four layers, i.e., an external layer composed of dense connective tissue, followed by a layer of undifferentiated cells, hyaline cartilage and bone. Few studies have demonstrated the behavior of the condylar cartilage when the mandible is positioned posteriorly, as in treatments for correcting functional Class III malocclusion. OBJECTIVE: The aim of this study was to assess the morphologic and histological aspects of rat condyles in response to posterior positioning of the mandible. METHODS: Thirty five-week-old male Wistar rats were selected and randomly divided into two groups: A control group (C) and an experimental group (E) which received devices for inducing mandibular retrusion. The animals were euthanized at time intervals of 7, 21 and 30 days after the experiment had began. For histological analysis, total condylar thickness was measured, including the proliferative, hyaline and hypertrophic layers, as well as each layer separately, totaling 30 measurements for each parameter of each animal. RESULTS: The greatest difference in cartilage thickness was observed in 21 days, although different levels were observed in the other periods. Group E showed an increase of 39.46% in the total layer, reflected by increases in the thickness of the hypertrophic (42.24%), hyaline (46.92%) and proliferative (17.70%) layers. CONCLUSIONS: Posteriorly repositioning the mandible produced a series of histological and morphological responses in the condyle, suggesting condylar and mandibular adaptation in rats.<\/jats:p>","DOI":"10.1590\/s2176-94512013000400016","type":"journal-article","created":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T10:51:12Z","timestamp":1386154272000},"page":"113-119","source":"Crossref","is-referenced-by-count":5,"title":["Morphometric evaluation of condylar cartilage of growing rats in response to mandibular retractive forces"],"prefix":"10.1590","volume":"18","author":[{"given":"Milena Peixoto Nogueira de","family":"S\u00e1","sequence":"first","affiliation":[{"name":"Universidade Estadual de Maring\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline Nelisis","family":"Zanoni","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Maring\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Luiz Fernandes de","family":"Salles","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil; Universidade Estadual de Maring\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabr\u00edcio Dias de","family":"Souza","sequence":"additional","affiliation":[{"name":"Escola Pernambucana de Odontologia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uhana Seifert Guimar\u00e3es","family":"Suga","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Maring\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel Sano Suga","family":"Terada","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0889-5406(86)90106-X","article-title":"The effects of mandibular retractive force on the growing rat mandible","volume":"90","author":"Asano T","year":"1986","journal-title":"Am J Orthod Dentofacial Orthop","ISSN":"http:\/\/id.crossref.org\/issn\/0889-5406","issn-type":"print"},{"issue":"1","key":"ref2","first-page":"46","article-title":"Changes in the rabbit temporomandibular joint associated with posterior displacement of the mandible","volume":"9","author":"Desai S","year":"1996","journal-title":"Int J Prosthodont","ISSN":"http:\/\/id.crossref.org\/issn\/0893-2174","issn-type":"print"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0889-5406(90)70028-B","article-title":"Mandibular rotation and enlargement","volume":"98","author":"Dibbets JM","year":"1990","journal-title":"Am J Orthod Dentofacial Orthop","ISSN":"http:\/\/id.crossref.org\/issn\/0889-5406","issn-type":"print"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1067\/mod.2003.5","article-title":"Lateral functional shift of the mandible: Part I. 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