{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T10:26:29Z","timestamp":1750242389117},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>The aim of this study was to investigate in vitro the antimicrobial effect and diffusion against E. faecalis of new intracanal medications on the external root surface. The medications tested were a placebo gel (PC); the new formulations with either 3% nitrofurantoin (NIT) or 3% doxycycline hydrochloride (DX) and 2% chlorhexidine (CHX) gel as positive control. The new formulations were tested using the traditional agar diffusion test (ADT) and an adapted agar diffusion method (AADM), where the teeth were filled with the medications and left to diffuse on agar surface seeded with E. faecalis. In the ADT, the larger zones of microbial growth inhibition were seen in DX, followed by CHX and NIT. In the AADM test only DX and CHX showed antimicrobial effect. Statistically significant differences between groups were observed by the Kruskal-Wallis test (2=47.126; p&lt;0.001). The new intracanal formulations with DX and NIT have demonstrated antimicrobial effect against E. faecalis, but only DX was able to diffuse through the dentinal tubules and exert antimicrobial effect outside the roots.<\/jats:p>","DOI":"10.1590\/0103-6440201302338","type":"journal-article","created":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T12:55:49Z","timestamp":1418907349000},"page":"425-429","source":"Crossref","is-referenced-by-count":11,"title":["Antimicrobial Effect and Transdentinal Diffusion of New Intracanal Formulations Containing Nitrofurantoin or Doxycycline"],"prefix":"10.1590","volume":"25","author":[{"given":"Ana Rita","family":"Silva","sequence":"first","affiliation":[{"name":"University of Oporto,  Portugal"}]},{"given":"Elizabete Brasil","family":"Santos","sequence":"additional","affiliation":[{"name":"Ponta Grossa State University,  Brazil"}]},{"given":"Shelon Cristina Souza","family":"Pinto","sequence":"additional","affiliation":[{"name":"Ponta Grossa State University,  Brazil"}]},{"given":"Jo\u00e3o Carlos","family":"Gomes","sequence":"additional","affiliation":[{"name":"Ponta Grossa State University,  Brazil"}]},{"given":"Irene Pina","family":"Vaz","sequence":"additional","affiliation":[{"name":"University of Oporto,  Portugal"}]},{"given":"Manuel Fontes","family":"Carvalho","sequence":"additional","affiliation":[{"name":"University of Oporto,  Portugal"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1079-2104(03)00353-6","article-title":"Polymerase chain reaction-based analysis of microorganisms associated with failed endodontic treatment","volume":"97","author":"Jr Siqueira JF","year":"2004","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1834-7819.2007.tb00527.x","article-title":"The use of calcium hydroxide, antibiotics and biocides as antimicrobial medicaments in endodontics","volume":"52","author":"Athanassiadis B","year":"2007","journal-title":"Aust Dent J"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S0099-2399(97)80314-7","article-title":"Determination of the p-monochlorophenol residue in the calcium hydroxide + P-monochlorophenol combination used as an intracanal dressing in pulpless teeth of dogs with induced chronic periapical lesion","volume":"23","author":"Alencar AH","year":"1997","journal-title":"J Endod"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1097\/00004770-200211000-00003","article-title":"Microbial susceptibility to calcium hydroxide pastes and their vehicles","volume":"28","author":"Gomes BP","year":"2002","journal-title":"J Endod"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1046\/j.1365-2591.2003.00634.x","article-title":"Effectiveness of 2% chlorhexidine gel and calcium hydroxide against Enterococcus faecalis in bovine root dentine in vitro","volume":"36","author":"Gomes BP","year":"2003","journal-title":"Int Endod J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/ijos.2013.12","article-title":"Antimicrobial activity of calcium hydroxide and chlorhexidine on intratubular Candida albicans","volume":"5","author":"Delgado RJ","year":"2013","journal-title":"International Journal of Oral Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1590\/0103-6440201302039","article-title":"Intracanal medications versus placebo in reducing postoperative endodontic pain--a double-blind randomized clinical trial","volume":"24","author":"Singh RD","year":"2013","journal-title":"Braz Dent J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.joen.2011.04.014","article-title":"Discoloration of teeth after avulsion and replantation: results from a multicenter randomized controlled trial","volume":"37","author":"Day PF","year":"2011","journal-title":"J Endod"},{"key":"ref9","first-page":"98","article-title":"Antibiotics as intracanal medicaments: a review","volume":"37","author":"Mohammadi Z","year":"2009","journal-title":"J Calif Dent Assoc"},{"key":"ref10","first-page":"90","article-title":"Evaluation of efficacy of combinations of five endodontic sealers with five antibiotics against Enterococcus faecalis - 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