{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:04:14Z","timestamp":1753887854933,"version":"3.41.2"},"reference-count":44,"publisher":"FapUNIFESP (SciELO)","issue":"9","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cienc. Rural"],"abstract":"<jats:p>ABSTRACT: Autosomal dominant polycystic kidney disease (ADPKD) has been related to left ventricular structural and functional abnormalities in human patients. The present study aimed to evaluate the cardiac structural and functional findings in Persian cats with ADPKD. Client-owned ADPKD (n=12) and non-ADPKD (n=12) Persian cats were enrolled in this study. The animals underwent echo- and electrocardiographic (ECG) examinations, and non-invasive measurements of systolic blood pressure (SBP) were obtained. Both groups were similar regarding hematological and biochemical parameters, including white blood cell count and levels of blood urea nitrogen, creatinine, total protein and thyroxine. There were no differences related to ECG parameters between ADPKD and non-ADPKD cats. Left ventricular hypertrophy (LVH) was demonstrated in 6\/12 (50%) normotensive ADPKD cats with preserved renal function. There were no differences between animal groups regarding the echocardiographic parameters, including left ventricular ejection fraction and shortening fraction; however, basal interventricular septal thickness at end-diastole near the left ventricular outflow tract and aortic artery flow velocity showed slightly elevated values in ADPKD-cats. Our study revealed that Persian cats with ADPKD do not reproduce the functional and structural cardiac phenotype reported in human patients; however, large-scale cohort studies are necessary to distinguish the possibilities of a true linkage between ventricular myocardial hypertrophy and ADPKD in this breed.<\/jats:p>","DOI":"10.1590\/0103-8478cr20191020","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T00:48:18Z","timestamp":1596847698000},"source":"Crossref","is-referenced-by-count":0,"title":["Cardiac structural and functional findings in Persian cats with autosomal dominant polycystic kidney disease"],"prefix":"10.1590","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0326-7187","authenticated-orcid":false,"given":"Juliana Mariotti","family":"Guerra","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil; Instituto Adolfo Lutz, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3841-0745","authenticated-orcid":false,"given":"Arine","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0520-614X","authenticated-orcid":false,"given":"Alexandre Gon\u00e7alves Teixeira","family":"Daniel","sequence":"additional","affiliation":[{"name":"Gattos - Cl\u00ednica Especializada em Medicina Felina, Brasil"}]},{"given":"Mariana Ferreira de","family":"Freitas","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3296-9735","authenticated-orcid":false,"given":"Nat\u00e1lia Cavalca","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3070-1700","authenticated-orcid":false,"given":"Rebecca Bastos","family":"Pessoa","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}]},{"given":"Gabriel Garone de","family":"Lucca","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5302-9064","authenticated-orcid":false,"given":"Maria Helena Matiko Akao","family":"Larsson","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4053-5419","authenticated-orcid":false,"given":"Luiz Fernando","family":"Onuchic","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6130-8381","authenticated-orcid":false,"given":"Felisbina Luisa","family":"Queiroga","sequence":"additional","affiliation":[{"name":"Universidade de Tr\u00e1s-os-Montes e Alto Douro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1388-7240","authenticated-orcid":false,"given":"Bruno","family":"Cogliati","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}]}],"member":"530","published-online":{"date-parts":[[2020]]},"reference":[{"issue":"7","key":"ref1","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1590\/S0100-879X2011007500068","article-title":"Molecular and cellular pathogenesis of autosomal dominant polycystic kidney disease.","volume":"44","author":"BASTOS A.P.","year":"2011","journal-title":"Brazilian Journal of Medical and Biological Research"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.kint.2016.04.028","article-title":"Cardiac dysfunction in Pkd1-deficient mice with phenotype rescue by galectin-3 knockout.","volume":"90","author":"BALBO B.E.","year":"2016","journal-title":"Kidney International"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1939-1676.1999.tb01141.x","article-title":"Evaluation of the white-coat effect in cats","volume":"13","author":"BELEW A.M.","year":"1999","journal-title":"Journal of Veterinary Internal Medicine"},{"issue":"8","key":"ref4","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.2460\/javma.1990.196.08.1288","article-title":"Polycystic kidney disease in a family of Persian cats.","volume":"196","author":"BILLER D.S.","year":"1990","journal-title":"Journal of the American Veterinary Medical Association"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jfms.2008.10.003","article-title":"Comparison between ultrasound and genetic testing for the early diagnosis of polycystic kidney disease in Persian and Exotic Shorthair cats.","volume":"11","author":"BONAZZI M.","year":"2009","journal-title":"Journal of Feline Medicine and Surgery"},{"key":"ref6","series-title":"Veterinary Echocardiography","author":"BOON J.A.","year":"2011","edition":"2"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1080\/01652176.1998.9694858","article-title":"Polycystic kidney and liver disease in cats","volume":"20","author":"BOSJE J.T.","year":"1998","journal-title":"The Veterinary Quarterly"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/j.1939-1676.2007.tb03005.x","article-title":"Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats","volume":"21","author":"BROWN S.","year":"2007","journal-title":"Journal of Veterinary Internal Medicine"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1681\/ASN.2017050483","article-title":"Genetic complexity of autosomal dominant polycystic kidney and liver diseases.","volume":"29","author":"CORNEC-LE GALL E.","year":"2018","journal-title":"Journal of the American Society of Nephrology"},{"issue":"8","key":"ref10","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1681\/ASN.V881292","article-title":"Left ventricular hypertrophy in autosomal dominant polycystic kidney disease","volume":"8","author":"CHAPMAN A.B.","year":"1997","journal-title":"Journal of the American Society of Nephrology"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"681","DOI":"10.4067\/S0716-97602004000400026","article-title":"The gating of polycystin signaling complex","volume":"37","author":"DELMAS P.","year":"2004","journal-title":"Biological Research"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/030098589703400204","article-title":"Autosomal dominant polycystic kidney disease in Persian and Persian-cross cats","volume":"34","author":"EATON K.A.","year":"1997","journal-title":"Veterinary Pathology"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1093\/ndt\/14.5.1113","article-title":"Reversal of left ventricular hypertrophy with angiotensin converting enzyme inhibition in hypertensive patients with autosomal dominant polycystic kidney disease.","volume":"14","author":"ECDER T.","year":"1999","journal-title":"Nephrology Dialysis Transplantation"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":".2","DOI":"10.2174\/1573402111309010002","article-title":"Cardiovascular complications in autosomal dominant polycystic kidney disease.","volume":"9","author":"ECDER T.","year":"2013","journal-title":"Current Hypertension Reviews,"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jfms.2009.01.002","article-title":"Feline myocardial disease 2: diagnosis, prognosis and clinical management","volume":"11","author":"FERASIN L","year":"2009","journal-title":"Journal of Feline Medicine and Surgery"},{"issue":"12","key":"ref16","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1681\/ASN.V5122048","article-title":"Causes of death in autosomal dominant polycystic kidney disease","volume":"5","author":"FICK G.M.","year":"1995","journal-title":"Journal of the American Society of Nephrology"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/ki.2013.501","article-title":"Renal cyst growth is the main determinant for hypertension and concentrating deficit in Pkd1-deficient mice.","volume":"85","author":"FONSECA J.M.","year":"2014","journal-title":"Kidney International"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1161\/01.CIR.56.2.273","article-title":"Echocardiographic assessment of a normal adult aging population.","volume":"56","author":"GERSTENBLITH G.","year":"1977","journal-title":"Circulation"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","DOI":"10.1177\/2055116915619191","article-title":"Congenital hepatic fibrosis and polycystic kidney disease not linked to C >A mutation in exon 29 of PKD1 in a Persian cat.","volume":"1","author":"GUERRA J.M.","year":"2015","journal-title":"Journal of Feline Medicine and Surgery open reports"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1177\/1098612X18764591","article-title":"Age-based ultrasonographic criteria for diagnosis of autosomal dominant polycystic kidney disease in Persian cats","volume":"21","author":"GUERRA J.M.","year":"2019","journal-title":"Journal of Feline Medicine and Surgery,"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jfms.2010.11.007","article-title":"Feline systemic hypertension: Classification and pathogenesis","volume":"13","author":"JEPSON R.E","year":"2011","journal-title":"Journal of Feline Medicine and Surgery"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":".250","DOI":"10.1136\/hrt.2004.042473","article-title":"Left ventricular hypertrophy in hypertension: its arrhythmogenic potential.","volume":"91","author":"KAHAN T.","year":"2005","journal-title":"Heart"},{"issue":"24","key":"ref23","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1161\/01.CIR.99.24.3172","article-title":"Familial hypertrophic cardiomyopathy in maine coon cats: an animal model of human disease","volume":"99","author":"KITTLESON M.D.","year":"1999","journal-title":"Circulation"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1177\/104063871002200314","article-title":"Molecular detection of autosomal-dominant feline polycystic kidney disease by multiplex amplification refractory mutation system polymerase chain reaction","volume":"22","author":"LEE Y.J.","year":"2010","journal-title":"Journal of Veterinary Diagnostic Investigation"},{"key":"ref25","series-title":"Textbook of Veterinary Internal Medicine.","first-page":"179","volume-title":"Hypertension","author":"LITTMAN M.P","year":"2000","edition":"5"},{"key":"ref26","doi-asserted-by":"crossref","DOI":"10.1111\/jvim.15745","article-title":"ACVIM consensus statement guidelines for the classification, diagnosis, and management of cardiomyopathies in cats.","author":"LUIS FUENTES V.","year":"2020","journal-title":"urnal of Veterinary Internal Medicine,"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1097\/01.ASN.0000141776.38527.BB","article-title":"Feline polycystic kidney disease mutation identified in PKD1.","volume":"15","author":"LYONS L.A.","year":"2004","journal-title":"Journal of the American Society of Nephrology"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000013583","article-title":"Left ventricular hypertrophy in hypertensive patients with autosomal dominant polycystic kidney disease: Influence of blood pressure and humoral and neurohormonal factors.","volume":"20","author":"MARTINEZ-VEA A.","year":"2000","journal-title":"American Journal of Nephrology"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1053\/j.ajkd.2004.04.026","article-title":"Exercise blood pressure, cardiac structure, and diastolic function in young normotensive patients with polycystic kidney disease: A prehypertensive state","volume":"44","author":"MARTINEZ-VEA A.","year":"2004","journal-title":"American Journal of Kidney Diseases"},{"issue":"23","key":"ref30","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1093\/hmg\/ddi386","article-title":"A cardiac myosin binding protein C mutation in the Maine Coon cat with familial hypertrophic cardiomyopathya.","volume":"14","author":"MEURS K.M.","year":"2005","journal-title":"Human Molecular Genetics"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ygeno.2007.04.007","article-title":"A substitution mutation in the myosin binding protein C gene in ragdoll hypertrophic cardiomyopathy.","volume":"90","author":"MEURS K.M.","year":"2007","journal-title":"Genomics"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.yjmcc.2013.01.015","article-title":"Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy.","volume":"58","author":"PAAVOLA J.","year":"2013","journal-title":"Journal of Molecular and Cellular Cardiology,"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1939-1676.2003.tb01319.x","article-title":"Increased mean arterial pressure and aldosterone-to-renin ratio in Persian cats with polycystic kidney disease.","volume":"17","author":"PEDERSEN K.M.","year":"2013","journal-title":"Journal of Veterinary Internal Medicine,"},{"issue":"131","key":"ref34","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1161\/CIRCULATIONAHA.114.013537","article-title":"Polycystin-1 is a cardiomyocyte mechanosensor that governs l-type Ca2+ channel protein stability.","volume":"24","author":"PEDROZO Z.","year":"2015","journal-title":"Circulation"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000101828","article-title":"Temporal relationship between renal cyst development, hypertension and cardiac hypertrophy in a new rat model of autosomal recessive polycystic kidney disease..","volume":"30","author":"PHILLIPS J.K.","year":"2007","journal-title":"Kidney and Blood Pressure Research"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"202","DOI":"10.2460\/javma.2002.220.202","article-title":"Population and survival characteristics of cats with hypertrophic cardiomyopathy: 260 cases (1990-1999).","volume":"220","author":"RUSH J.E.","year":"2002","journal-title":"Journal of the American Veterinary Medical Association,"},{"issue":"6969","key":"ref37","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1136\/bmj.309.6969.1617","article-title":"Left ventricular mass in normotensive subjects with autosomal dominant polycystic kidney disease","volume":"309","author":"SAGGAR-MALIK A.K.","year":"1994","journal-title":"British Medical Journal"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1939-1676.2001.tb02299.x","article-title":"Effect of amlodipine on echocardiographic variables in cats with systemic hypertension","volume":"15","author":"SNYDER P.S.","year":"2001","journal-title":"Journal of Veterinary Internal Medicine,"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1939-1676.1993.tb01015.x","article-title":"Recommendations for standards in transthoracic two-dimensional echocardiography in the dog and cat. Echocardiography Committee of the Specialty of Cardiology, American College of Veterinary Internal Medicine","volume":"7","author":"THOMAS W.P.","year":"1993","journal-title":"Journal of Veterinary Internal Medicine,"},{"key":"ref40","series-title":"Essentials of canine and feline electrocardiography: interpretation and treatment.","author":"TILLEY L.P.","year":"1992","edition":"3"},{"issue":"5","key":"ref41","first-page":"245","article-title":"The spectrum of cardiovascular abnormalities in autosomal dominant polycystic kidney disease: a 10-year follow-up in a five-generation kindred","volume":"37","author":"TIMIO M.","year":"1992","journal-title":"Clinical Nephrology"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1681\/ASN.V1051020","article-title":"Ambulatory blood pressure and left ventricular mass in normotensive patients with autosomal dominant polycystic kidney disease.","volume":"10","author":"VALERO F.A.","year":"1999","journal-title":"Journal of the American Society of Nephrology"},{"issue":"8","key":"ref43","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1681\/ASN.V1181371","article-title":"Endothelium-dependent relaxation of small resistance vessels is impaired in patients with autosomal dominant polycystic kidney disease.","volume":"11","author":"WANG D.","year":"2000","journal-title":"Journal of the American Society of Nephrology"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1939-1676.2010.0514.x","article-title":"Association of A31P and A74T polymorphisms in the myosin binding protein C3 gene and hypertrophic cardiomyopathy in Maine Coon and other breed cats","volume":"24","author":"WESS G.","year":"2010","journal-title":"Journal of Veterinary Internal Medicine"}],"container-title":["Ci\u00eancia Rural"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/cr\/v50n9\/1678-4596-cr-50-09-e20191020.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T13:54:32Z","timestamp":1723384472000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0103-84782020000900602&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":44,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020]]}},"alternative-id":["S0103-84782020000900602"],"URL":"https:\/\/doi.org\/10.1590\/0103-8478cr20191020","relation":{},"ISSN":["1678-4596","0103-8478"],"issn-type":[{"type":"electronic","value":"1678-4596"},{"type":"print","value":"0103-8478"}],"subject":[],"published":{"date-parts":[[2020]]},"article-number":"e20191020"}}