{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:58:31Z","timestamp":1740142711011,"version":"3.37.3"},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Med Esporte"],"abstract":"<jats:p>ABSTRACT  Introduction: The popularity of ultra-endurance events is increasing worldwide. However, information about hematological parameters during repeated bouts of long-duration running, such as stages during a multi-stage ultramarathon (MSUM) is scarce.  Objective: The purpose of the study was to monitor daily hematologic assessment in a 230-km multistage ultramarathon (MSUM) in hot environmental conditions.  Methods: Eleven male and three female (n = 14) ultra-endurance runners entered this MSUM, which was conducted over five stages, covering a total distance of 230 km in hot ambient conditions. Peripheral blood samples were collected before and after each stage to determine leukocyte and erythrocytes parameters.  Results: Multilevel modelling considering all measurement points showed an increase for whole blood leukocyte and granulocyte counts at five stages of the MSUM and for monocytes until Stage 3 of the race. For erythrocyte parameters, decreases across stages were observed in hemoglobin concentration and hematocrit responses when computing\/considering all measurement points.  Conclusions: The results indicate that MSUM in a hot environment leads to a greater impact on leukocyte population responses and platelet variation in the initial stages of the race. We suggest that athletes may have a decrease in immune function in the early stages of the MSUM, probably with some transient risk of infectious. Nevertheless, a physiological adaptation to physical exertion and heat mitigates these changes in the subsequent stages of MSUM. Level of Evidence III; Case-control study.<\/jats:p>","DOI":"10.1590\/1517-869220182403171999","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T15:06:59Z","timestamp":1530716819000},"page":"206-211","source":"Crossref","is-referenced-by-count":2,"title":["DAILY HEMATOLOGIC ASSESSMENT DURING A 230-KM MULTISTAGE ULTRAMARATHON"],"prefix":"10.1590","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9342-5563","authenticated-orcid":false,"given":"Luciele Guerra","family":"Minuzzi","sequence":"first","affiliation":[{"name":"Universidade de Coimbra,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1498-949X","authenticated-orcid":false,"given":"Ana Maria","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Universidade de Coimbra,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2855-0296","authenticated-orcid":false,"given":"Humberto Moreira","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade de Campinas,  Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3069-486X","authenticated-orcid":false,"given":"Ricardo Jos\u00e9 da","family":"Costa","sequence":"additional","affiliation":[{"name":"Monash University,  Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9619-8618","authenticated-orcid":false,"given":"Luis","family":"Rama","sequence":"additional","affiliation":[{"name":"Universidade de Coimbra,  Portugal"}]}],"member":"530","published-online":{"date-parts":[[2018,5]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1123\/ijspp.7.4.310","article-title":"Ultramarathon runners: nature or nurture","volume":"7","author":"Knechtle B","year":"2012","journal-title":"Int J Sports Physiol Perform"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1249\/JSR.0b013e3182913c98","article-title":"Injury and illnesses prevention for ultramarathoners","volume":"12","author":"Krabak BJ","journal-title":"Curr Sports Med Rep"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"13. 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