{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T14:28:26Z","timestamp":1769524106762,"version":"3.49.0"},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"1","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Nephrol."],"abstract":"<jats:p>ABSTRACT  Introduction: Chronic kidney disease (CKD) is an independent risk factor for several unfavorable outcomes including cardiovascular disease (CVD), particularly in the elderly, who represent the most rapidly growing segment of the end-stage kidney disease (ESKD) population. Portugal has the highest European unadjusted incidence and prevalence rates of ESKD. In 2012, we started to follow a cohort of elderly CKD patients, we describe their baseline characteristics, risk profile, and cardiovascular disease burden.  Methods: All CKD patients aged 65 years and older referred to our department during 2012 were enrolled. Baseline data included: demographic, CKD stage, medication, comorbid conditions. Estimated glomerular filtration rate (eGFR) was calculated by the CKD-EPI formula.  Results: A total of 416 patients, 50% referred by primary care physicians, aged 77 \u00b1 7 years, 52% male, with a median eGFR of 32 mL\/min\/1.73m2 participated in the study. Fifty percent had diabetes (DM), 85% dyslipidemia, 96% hypertension; 26% were current\/former smokers, and 24% had a body mass index &gt; 30 kg\/m2. The prevalence of CVD was 62% and higher in stage 4-5 patients; in diabetics, it gradually increased with CKD progression (stage 3a &lt; stage 3b &lt; stage 4-5) (39, 58, 82%; p &lt; 0.001).  Conclusions: At baseline, our CKD elderly cohort had a higher burden of CVD. The prevalence of CVD was greater than in other European CKD cohorts. Lower level of eGFR was associated with a greater burden of CVD and was more pronounced in diabetics, highlighting the importance of strategically targeting cardiovascular risk reduction in these patients.<\/jats:p>","DOI":"10.1590\/2175-8239-jbn-2018-0120","type":"journal-article","created":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T18:07:11Z","timestamp":1547316431000},"page":"29-37","source":"Crossref","is-referenced-by-count":5,"title":["Demographic, clinical characteristics and cardiovascular disease burden in a Portuguese cohort of older chronic kidney disease patients"],"prefix":"10.1590","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0383-4994","authenticated-orcid":false,"given":"Josefina Maria Sousa Santos","family":"Lascasas","sequence":"first","affiliation":[{"name":"Centro Hospitalar do Porto,  Portugal; Universidade do Porto,  Portugal"}]},{"given":"Isabel","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto,  Portugal; Universidade do Porto,  Portugal; Universidade do Porto,  Portugal"}]},{"given":"Jorge","family":"Malheiro","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto,  Portugal; Universidade do Porto,  Portugal"}]},{"given":"Sofia","family":"Santos","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto,  Portugal"}]},{"given":"Andreia","family":"Campos","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto,  Portugal"}]},{"given":"Ana","family":"Castro","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto,  Portugal"}]},{"given":"Carla","family":"Moreira","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto,  Portugal"}]},{"given":"Sofia","family":"Correia","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto,  Portugal"}]},{"given":"Idalina","family":"Beir\u00e3o","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto,  Portugal; Universidade do Porto,  Portugal"}]},{"given":"Lu\u00edsa","family":"Lobato","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto,  Portugal; Universidade do Porto,  Portugal"}]},{"given":"Ant\u00f3nio","family":"Cabrita","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto,  Portugal"}]}],"member":"530","published-online":{"date-parts":[[2019,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0140-6736(13)60687-X","article-title":"Chronic kidney disease: global dimension and perspectives","volume":"382","author":"Jha V","year":"2013","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1053\/j.ajkd.2015.05.001","article-title":"US Renal Data System 2014 Annual Data Report: Epidemiology of Kidney Disease in the United States","volume":"66","author":"Saran R","year":"2015","journal-title":"Am J Kidney Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/ckj\/sfv014","article-title":"Renal replacement therapy in Europe: a summary of the 2012 ERA-EDTA Registry Annual Report","volume":"8","author":"Pippias M","year":"2015","journal-title":"Clin Kidney J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/ckj\/sfv151","article-title":"Renal replacement therapy in Europe: a summary of the 2013 ERA-EDTA Registry Annual Report with a focus on diabetes mellitus","volume":"9","author":"Kramer A","year":"2016","journal-title":"Clin Kidney J"},{"key":"ref5","series-title":"Substitutive Renal Therapy of Chronic Renal Disease in Portugal"},{"key":"ref6","first-page":"71","article-title":"Cardiorenal risk: an important clinical intersection","volume":"3","author":"McCullough PA","year":"2002","journal-title":"Rev Cardiovasc Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1681\/ASN.2007040422","article-title":"Age affects outcomes in chronic kidney disease","volume":"18","author":"O\u2019Hare AM","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s11606-010-1511-x","article-title":"Chronic kidney disease and the risk of end-stage renal disease versus death","volume":"26","author":"Dalrymple LS","year":"2011","journal-title":"J Gen Intern Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1136\/jim-2017-000480","article-title":"End-stage renal disease versus death in a Portuguese cohort of elderly patients: an approach using competing event analysis","volume":"65","author":"Santos J","year":"2017","journal-title":"J Investig Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). 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