{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T08:35:48Z","timestamp":1768034148332,"version":"3.49.0"},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","issue":"1","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Nephrol."],"abstract":"<jats:p>ABSTRACT Introduction: It has been suggested that cystatin C levels are modified by obesity and inflammation. Furthermore, cystatin C has been associated with cardiovascular events and mortality outcomes. Aim: To study the association of cystatin C with the metabolic profile and cardiovascular disease of peritoneal dialysis patients. Methods: Data collected included clinical, laboratorial, and multifrequency bioimpedance assessment of 52 stable peritoneal dialysis patients. Minimal residual renal function was defined as &gt; 2mL\/min\/1.73m2. Results: Serum cystatin C was not significantly associated with peritoneal or urinary cystatin C excretion. Negative correlation of cystatin C with normalized protein catabolic rate (rho -0.33, p = 0.02) and a trend towards positive correlation with relative body fat (rho 0.27, p = 0.05) were not independent from residual renal function. Cystatin C was not significantly associated with cardiovascular disease (p = 0.28), nor with glycated hemoglobin (p = 0.19) or c-reactive protein (p = 0.56). In the multivariate model, both age and diabetes were the strongest predictors of cardiovascular disease (odds ratio 1.09, p = 0.029 and odds ratio 29.95, p = 0.016, respectively), while relative body fat was negatively associated with cardiovascular disease (p = 0.038); neither cystatin C (p = 0.096) nor minimal residual renal function (p = 0.756) reached a significant association with cardiovascular disease. Conclusions: In this group of peritoneal dialysis patients, cystatin C did not correlate with the metabolic or inflammatory status, nor cardiovascular disease, after adjustment for residual renal function.<\/jats:p>","DOI":"10.1590\/2175-8239-jbn-2019-0007","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T13:15:53Z","timestamp":1575378953000},"page":"31-37","source":"Crossref","is-referenced-by-count":1,"title":["Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyond its association with residual renal function?"],"prefix":"10.1590","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7913-4460","authenticated-orcid":false,"given":"Carla Leal","family":"Moreira","sequence":"first","affiliation":[{"name":"Centro Hospitalar do Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5271-0640","authenticated-orcid":false,"given":"Liliana","family":"Cunha","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5025-1658","authenticated-orcid":false,"given":"Sofia","family":"Correia","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7818-6453","authenticated-orcid":false,"given":"Filipa","family":"Silva","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8328-2805","authenticated-orcid":false,"given":"Ana","family":"Castro","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3776-4923","authenticated-orcid":false,"given":"Joana","family":"Tavares","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4374-2867","authenticated-orcid":false,"given":"Maria 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