{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T07:33:39Z","timestamp":1758267219804,"version":"3.37.3"},"reference-count":12,"publisher":"FapUNIFESP (SciELO)","issue":"4","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Nephrol."],"abstract":"<jats:p>Abstract Introduction: Type 1 diabetes mellitus is associated with an increased risk of coronary artery disease, which is frequently asymptomatic. This risk increases significantly in those with nephropathy. In selected patients, simultaneous pancreas-kidney transplantation is the renal and pancreatic replacement therapy of choice, as it increases longevity and stabilizes diabetic complications. Despite essential, universal screening protocols are still controversial for coronary artery disease in this population. Methods: We retrospectively analysed 99 simultaneous pancreas-kidney recipients from our centre from 2011 to 2018 and selected 77 patients who underwent coronary angiography during the pre-transplant evaluation. Our aim was to identify potential risk factors associated with significant lesions on coronary angiography. Results: Almost half of our cohort of 77 candidates submitted to coronary angiography had coronary artery disease. Of these, nearly 30% underwent revascularization, although only one of them reported symptoms of myocardial ischemia. In a univariate analysis, the presence of smoking habits was the only risk factor for coronary artery disease. We also found that 20 or more years of type 1 diabetes mellitus was significantly associated with the presence of coronaropathy. Discussion: Selection of diabetic candidates with acceptable cardiac risk before simultaneous pancreas-kidney transplantation is imperative. Given the impact of a correct diagnosis and a low procedural risk, we defend the routine use of coronary angiography as the initial screening method for coronary artery disease in this population. Particularly care must be taken in evaluating asymptomatic patients with long-term type 1 diabetes mellitus and smokers.<\/jats:p>","DOI":"10.1590\/2175-8239-jbn-2021-0156","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T22:06:38Z","timestamp":1646172398000},"page":"522-526","source":"Crossref","is-referenced-by-count":4,"title":["The burden of coronary heart disease in simultaneous pancreas-kidney transplantation: coronary angiography as a diagnostic method for all? - a retrospective study"],"prefix":"10.1590","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7216-8086","authenticated-orcid":false,"given":"Joana","family":"Marques","sequence":"first","affiliation":[{"name":"Centro Hospitalar de Lisboa Central,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8031-7299","authenticated-orcid":false,"given":"Lu\u00edsa","family":"Pereira","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio do Algarve,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4734-6589","authenticated-orcid":false,"given":"Ana","family":"Messias","sequence":"additional","affiliation":[{"name":"Hospital Garcia de Orta,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0821-2764","authenticated-orcid":false,"given":"Nuno","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Centro Hospitalar de Lisboa Central,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1277-0622","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Cotovio","sequence":"additional","affiliation":[{"name":"Centro Hospitalar de Lisboa Central,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3300-6033","authenticated-orcid":false,"given":"An\u00edbal","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Centro Hospitalar de Lisboa Central,  Portugal; Hospital Curry Cabral,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7089-1975","authenticated-orcid":false,"given":"Fernando","family":"Nolasco","sequence":"additional","affiliation":[{"name":"Centro Hospitalar de Lisboa Central,  Portugal; Hospital Curry Cabral,  Portugal"}]}],"member":"530","published-online":{"date-parts":[[2022,12]]},"reference":[{"issue":"1","key":"ref1","first-page":"43","article-title":"Screening for coronary artery disease in asymptomatic diabetic patients","volume":"3","author":"Schuijf J","year":"2007","journal-title":"Eur Cardiovasc Dis"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1590\/2359-3997000000170","article-title":"Screening for asymptomatic coronary artery disease in patients with type 2 diabetes mellitus","volume":"60","author":"Tavares C","year":"2016","journal-title":"Arch Endocrinol Metab"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1093\/ndt\/gfs613","article-title":"Mortality in diabetes: pancreas transplantation is associated with significant survival benefit","volume":"28","author":"Van Dellen D","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"ref4","series-title":"Handbook of kidney transplantation","author":"Danovitch G","year":"2017","edition":"6"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/TP.0000000000003710","article-title":"Impact of simultaneous pancreas-kidney transplantation on cardiovascular risk in patients with diabetes","volume":"106","author":"Montagud-Marrahi E","year":"2021","journal-title":"Transplantation"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3390\/mps2040082","article-title":"Assessing pancreas transplant candidate cardiac disease: preoperative protocol development at a rapidly growing transplant program","volume":"2","author":"St. Michel D","year":"2019","journal-title":"Methods Protoc"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1097\/01.hjh.0000180159.81640.2f","article-title":"Cardiovascular risk profile with the new immunosuppressive combinations after renal transplantation","volume":"23","author":"Morales J","year":"2005","journal-title":"J Hypertens"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.transproceed.2004.02.036","article-title":"Cardiac evaluation for simultaneous pancreas-kidney transplantation and incidence of cardiac perioperative complications: preliminary study","volume":"36","author":"Fossati N","year":"2004","journal-title":"Transplant Proc"},{"issue":"8","key":"ref9","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1016\/j.transproceed.2010.07.046","article-title":"Cardiovascular events after simultaneous pancreas-kidney transplantation","volume":"42","author":"Medina-Polo J","year":"2010","journal-title":"Transplant Proc"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/MOT.0000000000000843","article-title":"Kidney and pancreas transplant candidacy","volume":"26","author":"Regmi S","year":"2020","journal-title":"Curr Opin Organ Transplant"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1111\/j.1600-6143.2006.01491.x","article-title":"Routine coronary angiography in diabetic nephropathy patients before transplantation","volume":"6","author":"Witczak B","year":"2006","journal-title":"Am J Transplant"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2459\/JCM.0000000000000742","article-title":"Assessment and management of coronary artery disease in kidney and pancreas transplant candidates","volume":"20","author":"Knapper J","year":"2019","journal-title":"J Cardiovasc Med"}],"container-title":["Brazilian Journal of Nephrology"],"original-title":["O peso da doen\u00e7a arterial coronariana no transplante de p\u00e2ncreas-rim simult\u00e2neo: angiografia coron\u00e1ria como m\u00e9todo diagn\u00f3stico para todos? - um estudo retrospectivo"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0101-28002022000400522&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T18:17:05Z","timestamp":1673288225000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0101-28002022000400522&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["S0101-28002022000400522"],"URL":"https:\/\/doi.org\/10.1590\/2175-8239-jbn-2021-0156","relation":{},"ISSN":["2175-8239","0101-2800"],"issn-type":[{"type":"electronic","value":"2175-8239"},{"type":"print","value":"0101-2800"}],"subject":[],"published":{"date-parts":[[2022,12]]}}}