{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T22:55:19Z","timestamp":1772232919124,"version":"3.50.1"},"reference-count":31,"publisher":"FapUNIFESP (SciELO)","issue":"4","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Nephrol."],"abstract":"<jats:p>Abstract  Introduction: Obesity is thought to play a role in the disruption of cardiac rhythmicity in obese children, but this is mostly an unexplored field of investigation. We aimed to evaluate the impact of overweight and obesity on circadian and ultradian cardiovascular rhythmicity of prepubertal children, in comparison with normal weight counterparts.  Methods: We performed a cross sectional study of 316 children, followed in the birth cohort Generation XXI (Portugal). Anthropometrics and 24-hour ambulatory blood pressure were measured and profiles were examined with Fourier analysis for circadian and ultradian blood pressure (BP) and heart rate (HR) rhythms.  Results: Overweight\/obese children presented more frequently a non-dipping BP pattern than normal weight counterparts (31.5% vs. 21.6%, p = 0.047). The prevalence of 24-hour mean arterial pressure (MAP) and 8-hour HR rhythmicity was significantly lower in obese children (79.3% vs. 88.0%, p = 0.038 and 33.3% vs. 45.2%, p = 0.031, respectively). The prevalence of the remaining MAP and HR rhythmicity was similar in both groups. No differences were found in the median values of amplitudes and acrophases of MAP and HR rhythms.  Discussion: The alterations found in rhythmicity suggest that circadian and ultradian rhythmicity analysis might be sensitive in detecting early cardiovascular dysregulations, but future studies are needed to reinforce our findings and to better understand their long-term implications.<\/jats:p>","DOI":"10.1590\/2175-8239-jbn-2022-0138en","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T08:18:44Z","timestamp":1690791524000},"page":"449-457","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular rhythmicity in overweight and obese children"],"prefix":"10.1590","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6728-4149","authenticated-orcid":false,"given":"Catarina","family":"Pinto-Silva","sequence":"first","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio de Coimbra,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3197-5842","authenticated-orcid":false,"given":"Ana","family":"Correia-Costa","sequence":"additional","affiliation":[{"name":"Universidade do Porto,  Portugal; Centro Hospitalar e Universit\u00e1rio de S\u00e3o Jo\u00e3o,  Portugal"}]},{"given":"Cl\u00e1udia","family":"Moura","sequence":"additional","affiliation":[{"name":"Universidade do Porto,  Portugal; Centro Hospitalar e Universit\u00e1rio de S\u00e3o Jo\u00e3o,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7888-2351","authenticated-orcid":false,"given":"Cl\u00e1udia","family":"Mota","sequence":"additional","affiliation":[{"name":"Universidade do Porto,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7951-3911","authenticated-orcid":false,"given":"Ant\u00f3nio","family":"Guerra","sequence":"additional","affiliation":[{"name":"Centro Hospitalar e Universit\u00e1rio de S\u00e3o Jo\u00e3o,  Portugal; Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9833-2518","authenticated-orcid":false,"given":"Jos\u00e9 Carlos","family":"Areias","sequence":"additional","affiliation":[{"name":"Universidade do Porto,  Portugal; Centro Hospitalar e Universit\u00e1rio de S\u00e3o Jo\u00e3o,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7564-9937","authenticated-orcid":false,"given":"Franz","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Universidade de Heidelberg,  Alemanha"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2574-4132","authenticated-orcid":false,"given":"Alberto Caldas","family":"Afonso","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio,  Portugal; Universidade do Porto,  Portugal; Universidade do Porto,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1205-2620","authenticated-orcid":false,"given":"Elke","family":"W\u00fchl","sequence":"additional","affiliation":[{"name":"Universidade de Heidelberg,  Alemanha"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7368-9609","authenticated-orcid":false,"given":"Ana","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Universidade do Porto,  Portugal; Universidade do Porto, Faculdade de Medicina,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8216-090X","authenticated-orcid":false,"given":"Liane","family":"Correia-Costa","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio,  Portugal; Universidade do Porto,  Portugal; Universidade do Porto,  Portugal"}]}],"member":"530","published-online":{"date-parts":[[2023,12]]},"reference":[{"issue":"9986","key":"ref1","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1016\/S0140-6736(14)61746-3","article-title":"Child and adolescent obesity: part of a bigger picture","volume":"385","author":"Lobstein T","year":"2015","journal-title":"Lancet."},{"issue":"10113","key":"ref2","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1016\/S0140-6736(17)32129-3","article-title":"Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults","volume":"390","author":"Abarca-G\u00f3mez L","year":"2017","journal-title":"Lancet."},{"issue":"14","key":"ref3","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1161\/CIRCULATIONAHA.111.047738","article-title":"Childhood obesity","volume":"126","author":"Lakshman R","year":"2012","journal-title":"Circulation."},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/pch\/14.3.177","article-title":"Childhood obesity and cardiovascular disease","volume":"14","author":"Bridger T.","year":"2009","journal-title":"Paediatr Child Health."},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF02322051","article-title":"Heart rate variability in childhood obesity","volume":"11","author":"Martini G","year":"2001","journal-title":"Clin Auton Res."},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1097\/HJH.0b013e3282775992","article-title":"Ambulatory blood pressure monitoring and target organ damage in pediatrics","volume":"25","author":"Stabouli S","year":"2007","journal-title":"J Hypertens."},{"issue":"14","key":"ref7","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1161\/01.CIR.0000160923.04524.5B","article-title":"Prognostic value of ambulatory and home blood pressures compared with office blood pressure in the general population: follow-up results from the Pressioni Arteriose Monitorate e Loro Associazioni (PAMELA) study","volume":"111","author":"Sega R","year":"2005","journal-title":"Circulation."},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1161\/HYP.0000000000000007","article-title":"Update: ambulatory blood pressure monitoring in children and adolescents: a scientific statement from the American Heart Association","volume":"63","author":"Flynn JT","year":"2014","journal-title":"Hypertension."},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11906-009-0024-7","article-title":"Ambulatory blood pressure monitoring in childhood and adult obesity","volume":"11","author":"Ben-Dov IZ","year":"2009","journal-title":"Curr Hypertens Rep."},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1097\/HJH.0000000000000188","article-title":"Effect of changes in BMI and waist circumference on ambulatory blood pressure in obese children and adolescents","volume":"32","author":"Hvidt KN","year":"2014","journal-title":"J Hypertens."},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1161\/01.HYP.0000116754.15808.d8","article-title":"German Study Group for Pediatric Hypertension. 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