{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T22:57:14Z","timestamp":1772233034028,"version":"3.50.1"},"reference-count":44,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Nephrol."],"abstract":"<jats:p>RESUMO  Introdu\u00e7\u00e3o: Insufici\u00eancia renal aguda (IRA) \u00e9 uma deteriora\u00e7\u00e3o abrupta da fun\u00e7\u00e3o renal. A incid\u00eancia de IRA pedi\u00e1trica est\u00e1 aumentando em todo o mundo, em ambientes cr\u00edticos e n\u00e3o cr\u00edticos. Nosso objetivo foi caracterizar apresenta\u00e7\u00e3o, etiologia, evolu\u00e7\u00e3o e desfechos da IRA em pacientes pedi\u00e1tricos internados em um centro de atendimento terci\u00e1rio.  M\u00e9todos: Realizamos estudo retrospectivo observacional de centro \u00fanico de pacientes com idade entre 29 dias a 17 anos e 365 dias internados em nossa Unidade de Nefrologia Pedi\u00e1trica, de janeiro de 2012 a dezembro de 2021, com diagn\u00f3stico de IRA. A gravidade da IRA foi categorizada de acordo com os crit\u00e9rios do Kidney Disease Improving Global Outcomes (KDIGO). Os desfechos considerados foram \u00f3bito ou sequelas (protein\u00faria, hipertens\u00e3o ou altera\u00e7\u00f5es na fun\u00e7\u00e3o renal em avalia\u00e7\u00f5es de acompanhamento de 3 a 6 meses).  Resultados: Inclu\u00edmos 46 pacientes com idade mediana de 13,0 (3,5\u201315,5) anos. Cerca de metade (n = 24; 52,2%) apresentou um fator de risco identific\u00e1vel para o desenvolvimento de IRA. Treze pacientes (28,3%) eram an\u00faricos; todos foram classificados como IRA KDIGO 3 (p &lt; 0,001). Quase um quarto (n = 10; 21,7%) dos pacientes necessitaram de terapia renal substitutiva. Aproximadamente 60% (n = 26) apresentou pelo menos uma sequela, sendo protein\u00faria a mais comum (n = 15; 38,5%; mediana (P25\u201375) da rela\u00e7\u00e3o prote\u00edna\/creatinina urin\u00e1ria 0,30 (0,27\u20130,44) mg\/mg), seguida de taxa de filtra\u00e7\u00e3o glomerular (TFG) reduzida (n = 11; 27,5%; mediana (P25\u201375) da TFG 75 (62\u201383) mL\/min\/1,73 m2).  Conclus\u00f5es: A IRA pedi\u00e1trica est\u00e1 associada \u00e0 morbidade substancial, com potencial para desenvolvimento de protein\u00faria e comprometimento da fun\u00e7\u00e3o renal e impacto relevante no progn\u00f3stico de longo prazo.<\/jats:p>","DOI":"10.1590\/2175-8239-jbn-2024-0012pt","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T16:01:48Z","timestamp":1714752108000},"source":"Crossref","is-referenced-by-count":0,"title":["Insufici\u00eancia renal aguda: experi\u00eancia de um centro terci\u00e1rio de Nefrologia Pedi\u00e1trica"],"prefix":"10.1590","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4491-6948","authenticated-orcid":false,"given":"Carolina Silva","family":"Figueiredo","sequence":"first","affiliation":[{"name":"Hospital do Divino Esp\u00edrito Santo de Ponta Delgada,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5804-0845","authenticated-orcid":false,"given":"Ana Margarida Neto da","family":"Rocha","sequence":"additional","affiliation":[{"name":"Universidade do Porto,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8216-090X","authenticated-orcid":false,"given":"Liane Maria Correia Rodrigues da Costa Nogueira","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade do Porto,  Portugal; Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio,  Portugal; Universidade do Porto,  Portugal; Universidade do Porto,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8061-9289","authenticated-orcid":false,"given":"Maria do Sameiro Pinto C\u00e9sar de","family":"Faria","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio,  Portugal; Universidade do Porto e Universidade NOVA de Lisboa,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6478-4241","authenticated-orcid":false,"given":"Teresa Maria Tavares Vieira da Costa","family":"Tavares","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4741-0002","authenticated-orcid":false,"given":"Maria da Concei\u00e7\u00e3o Oliveira Costa","family":"Mota","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio,  Portugal"}]}],"member":"530","published-online":{"date-parts":[[2024,9]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3339\/jkspn.2020.24.1.19","article-title":"Pediatric acute kidney injury: focusing on diagnosis and management.","volume":"24","author":"Cho M","year":"2020","journal-title":"Child Kidney Dis."},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/kisup.2012.7","article-title":"KDIGO clinical practice guideline for acute kidney injury: summary of recommendation 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