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Nephrol."],"abstract":"<jats:p>Resumo  Introdu\u00e7\u00e3o: No noroeste de Portugal, a amiloidose AA foi relatada como a nefropatia amiloide mais frequente, embora n\u00e3o esteja claro se a incid\u00eancia e desfechos da doen\u00e7a mudaram. Os autores analisaram altera\u00e7\u00f5es na epidemiologia, etiologias e desfechos de pacientes com amiloidose renal AA nos \u00faltimos 40 anos.  M\u00e9todos: Estudo de coorte retrospectivo de centro \u00fanico, envolvendo pacientes com diagn\u00f3stico de amiloidose AA comprovada por bi\u00f3psia renal, realizado no noroeste de Portugal entre 1978 e 2019. Os pacientes foram agrupados em coortes de 14 anos baseadas no ano do diagn\u00f3stico (CA 1978\u20131991; CB 1992\u20132005; CC 2006\u20132019), com an\u00e1lises de evolu\u00e7\u00e3o cl\u00ednica e desfechos.  Resultados: Inclu\u00edmos 69 pacientes com amiloidose AA. A incid\u00eancia da doen\u00e7a permaneceu est\u00e1vel em CA (64%) e CB (62,7%), em oposi\u00e7\u00e3o \u00e0 redu\u00e7\u00e3o significativa na coorte mais recente (44%, p = 0,027). A idade m\u00e9dia na apresenta\u00e7\u00e3o aumentou em dez anos de CA para CC. No geral, infec\u00e7\u00f5es foram a principal causa de \u00f3bito, com aumento significativo ao longo do tempo (9,1% na CA para 76,9% na CC; p = 0,002). N\u00e3o houve diferen\u00e7as significativas de sobrevida global e renal entre as tr\u00eas coortes. Entretanto, pacientes na CC faleceram com idade mais avan\u00e7ada (61,4 anos) do que na CA (52,3 anos).  Conclus\u00e3o: A incid\u00eancia de amiloidose AA tem diminu\u00eddo nos \u00faltimos 40 anos. Em contrapartida, a idade de apresenta\u00e7\u00e3o da nefropatia amiloide tem aumentado. Desfechos globais e renais n\u00e3o melhoraram, mas a expectativa de vida m\u00e9dia aumentou, sugerindo progresso no manejo geral e no tratamento de suporte da patologia renal e subjacente.<\/jats:p>","DOI":"10.1590\/2175-8239-jbn-2024-0127pt","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T11:31:58Z","timestamp":1738582318000},"source":"Crossref","is-referenced-by-count":0,"title":["Novas tend\u00eancias na amiloidose AA com envolvimento renal: experi\u00eancia de um \u00fanico centro"],"prefix":"10.1590","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5520-6899","authenticated-orcid":false,"given":"N\u00eddia","family":"Marques","sequence":"first","affiliation":[{"name":"Unidade Local de Sa\u00fade S\u00e3o Jo\u00e3o,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5447-0644","authenticated-orcid":false,"given":"Catarina","family":"Oliveira-Silva","sequence":"additional","affiliation":[{"name":"Unidade Local de Sa\u00fade de Braga,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9115-4683","authenticated-orcid":false,"given":"Ana","family":"Pinho","sequence":"additional","affiliation":[{"name":"Unidade Local de Sa\u00fade S\u00e3o Jo\u00e3o,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3483-4981","authenticated-orcid":false,"given":"Ana Teresa","family":"Nunes","sequence":"additional","affiliation":[{"name":"Unidade Local de Sa\u00fade S\u00e3o Jo\u00e3o,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8626-9235","authenticated-orcid":false,"given":"Susana","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Unidade Local de Sa\u00fade S\u00e3o Jo\u00e3o,  Portugal; Universidade do Porto,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5728-4572","authenticated-orcid":false,"given":"Ana","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Unidade Local de Sa\u00fade S\u00e3o Jo\u00e3o,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3497-8416","authenticated-orcid":false,"given":"Isabel","family":"Tavares","sequence":"additional","affiliation":[{"name":"Unidade Local de Sa\u00fade S\u00e3o Jo\u00e3o,  Portugal; Universidade do Porto,  Portugal"}]}],"member":"530","published-online":{"date-parts":[[2025,4]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1080\/13506129.2019.1640672","article-title":"A new era of amyloidosis: the trends at a major US referral centre","volume":"26","author":"Staron A","year":"2019","journal-title":"Amyloid"},{"issue":"6","key":"ref2","first-page":"535","article-title":"Clinical outcomes and survival in AA amyloidosis patients","volume":"57","author":"Ayar Y","year":"2017","journal-title":"Rev Bras Reumatol Engl Ed"},{"issue":"16","key":"ref3","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1056\/NEJMc1917321","article-title":"Epidemiologic and survival trends in Amyloidosis, 1987\u20132019","volume":"382","author":"Ravichandran S","year":"2020","journal-title":"N Engl J Med"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s11255-009-9524-2","article-title":"Renal AA amyloidosis: survey of epidemiologic and laboratory data from one nephrology centre","volume":"41","author":"Poty\u0161ov\u00e1 Z","year":"2009","journal-title":"Int Urol Nephrol"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"e13966","DOI":"10.1111\/ijcp.13966","article-title":"Infections and AA amyloidosis: an overview","volume":"75","author":"Deshayes S","year":"2021","journal-title":"Int J Clin Pract"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.kint.2021.12.002","article-title":"AA amyloidosis without systemic inflammation: when clinical evidence validates predictions of experimental medicine","volume":"101","author":"Laura Obici VB.","year":"2022","journal-title":"Kidney Int"},{"issue":"23","key":"ref7","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1056\/NEJMoa070265","article-title":"Natural history and outcome in Systemic AA amyloidosis","volume":"356","author":"Lachmann HJ","year":"2007","journal-title":"N Engl J Med"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1093\/ndt\/gfm041","article-title":"Renal involvement in systemic amyloidosis - 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