{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:40:23Z","timestamp":1762641623910,"version":"3.40.5"},"reference-count":8,"publisher":"FapUNIFESP (SciELO)","issue":"6 suppl 1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An. Bras. Dermatol."],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>Crohn's disease is a multisystem chronic granulomatous inflammatory disease that primarily affects the gastrointestinal tract. In the majority of the cases, the cutaneous manifestations follow the intestinal disease, but occasionally dermatological lesions are the inaugural event and may constitute the only sign of the disease. Vulvoperineal involvement is rare, may precede bowel symptoms by months to years and may go unrecognized. Due to the paucity of reports of Crohn's disease at this location and in the absence of randomized trials, there are no standard treatments for the cutaneous disease. We describe the case of a 47 year-old woman with vulvoperineal Crohn's disease without digestive involvement, that was successfully managed with metronidazole.<\/jats:p>","DOI":"10.1590\/abd1806-4841.20132243","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T19:47:19Z","timestamp":1391111239000},"page":"71-74","source":"Crossref","is-referenced-by-count":10,"title":["Vulvoperineal Crohn's disease responsive to metronidazole"],"prefix":"10.1590","volume":"88","author":[{"given":"Arist\u00f3teles","family":"Rosmaninho","sequence":"first","affiliation":[{"name":"Hospital Center at Porto, Portugal"}]},{"given":"Madalena","family":"Sanches","sequence":"additional","affiliation":[{"name":"Hospital Center at Porto, Portugal"}]},{"given":"Marta","family":"Salgado","sequence":"additional","affiliation":[{"name":"Hospital Center at Porto, Portugal"}]},{"given":"Ros\u00e1rio","family":"Alves","sequence":"additional","affiliation":[{"name":"Hospital Center at Porto, Portugal"}]},{"given":"Manuela","family":"Selores","sequence":"additional","affiliation":[{"name":"Hospital Center at Porto, Portugal"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1684\/ejd.2009.0674","article-title":"Crohn's disease: an important differential diagnosis of granulomatous skin diseases","volume":"19","author":"Eames T","year":"2009","journal-title":"Eur J Dermatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ijsu.2009.09.012","article-title":"Crohn's disease of the vulva","volume":"8","author":"Andreani SM","year":"2010","journal-title":"Int J Surg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"342","DOI":"10.4103\/0378-6323.79724","article-title":"Isolated Crohn's disease of the vulva","volume":"77","author":"Madnani NA","year":"2011","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"ref4","first-page":"240","article-title":"Vulvoperineal Crohn's disease: response to metronidazole","volume":"8","author":"Khaled A","year":"2010","journal-title":"Skinmed"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jaad.2009.07.041","article-title":"Metastatic Crohn disease: clearance with metronidazole","volume":"64","author":"Abide JM","year":"2011","journal-title":"J Am Acad Dermatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s11938-005-0014-z","article-title":"The role of antibiotics in inflammatory bowel disease","volume":"8","author":"Thukral C","year":"2005","journal-title":"Curr Treat Options Gastroenterol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1590\/S0365-05962009000600011","article-title":"Metastatic Crohn's disease without intestinal clinical manifestation","volume":"84","author":"Fernandes MD","year":"2009","journal-title":"An Bras Dermatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0016-5085(82)80332-6","article-title":"Metronidazole therapy for perineal Crohn's disease: a follow-up study","volume":"83","author":"Brandt LJ","year":"1982","journal-title":"Gastroenterology"}],"container-title":["Anais Brasileiros de Dermatologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abd\/v88n6s1\/0365-0596-abd-88-06-s1-0071.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T15:00:42Z","timestamp":1747666842000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0365-05962013000800071&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":8,"journal-issue":{"issue":"6 suppl 1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0365-05962013000800071"],"URL":"https:\/\/doi.org\/10.1590\/abd1806-4841.20132243","relation":{},"ISSN":["0365-0596"],"issn-type":[{"type":"electronic","value":"0365-0596"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}