{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:49:46Z","timestamp":1773409786259,"version":"3.50.1"},"reference-count":17,"publisher":"FapUNIFESP (SciELO)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>Ectopic ACTH syndrome is a rare disease often associated with severe hypercortisolism. When feasible, optimal management is surgical excision of the tumor. A 33-year-old male patient was admitted to the hospital in 1993 with clinical manifestations suggestive of Cushing's syndrome. He presented high plasma ACTH and markedly elevated urinary free cortisol excretion that was not suppressed with high-dose dexamethasone administration. Pituitary MRI scan was normal. No central-to-peripheral ACTH gradient was present in bilateral inferior petrosal sinus sampling. Thoracic CT scan showed a 1.7 cm nodule at the left lung. Pulmonary fine needle cytology and immunocytochemical and ultrastructural studies, together with the presence of bone metastases, led to the diagnosis of an ACTH-producing neuroendocrine carcinoma. He was initially submitted to chemotherapy and has been on treatment with octreotide LAR since 1998, having shown a favorable clinical, biochemical and imaging response. We highlight the excellent long-term response to medical therapy with octreotide LAR, without tachyphylaxis, probably due to its antiproliferative effect.<\/jats:p>","DOI":"10.1590\/s0004-27302012000700009","type":"journal-article","created":{"date-parts":[[2012,10,27]],"date-time":"2012-10-27T04:37:35Z","timestamp":1351312655000},"page":"461-464","source":"Crossref","is-referenced-by-count":7,"title":["Ectopic Cushing's syndrome caused by a pulmonary ACTH-secreting tumor in a patient treated with octreotide"],"prefix":"10.1590","volume":"56","author":[{"given":"Pedro","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Centro Hospitalar de S\u00e3o Jo\u00e3o EPE,  Portugal; Porto Medical School,  Portugal"}]},{"given":"Jos\u00e9 Lu\u00eds","family":"Castedo","sequence":"additional","affiliation":[{"name":"Centro Hospitalar de S\u00e3o Jo\u00e3o EPE,  Portugal"}]},{"given":"Margarida","family":"Damasceno","sequence":"additional","affiliation":[{"name":"Centro Hospitalar de S\u00e3o Jo\u00e3o EPE,  Portugal"}]},{"given":"Davide","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Centro Hospitalar de S\u00e3o Jo\u00e3o EPE,  Portugal; Porto Medical School,  Portugal"}]}],"member":"530","reference":[{"issue":"8","key":"ref1","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1590\/S0004-27302007000800007","article-title":"Ectopic ACTH syndrome","volume":"51","author":"Isidori AM","year":"2007","journal-title":"Arq Bras Endocrinol Metab"},{"key":"ref2","first-page":"752","article-title":"Ectopic hormone production by tumors: mechanisms involved and the biological and clinical implications","volume":"15","author":"Baylin SB","year":"1980","journal-title":"Endocr Rev","ISSN":"https:\/\/id.crossref.org\/issn\/0163-769X","issn-type":"print"},{"key":"ref3","series-title":"Greenspan's Basic and Clinical Endocrinology","first-page":"346","volume-title":"Glucocorticoids and adrenal androgens","author":"Aron 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