{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T02:41:46Z","timestamp":1699238506558},"reference-count":16,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>OBJETIVO: Detectar altera\u00e7\u00f5es nos \u00edndices plaquet\u00e1rios em indiv\u00edduos com doen\u00e7a hep\u00e1tica alco\u00f3lica cr\u00f3nica e trombocitopenia e determinar o seu grau de correla\u00e7\u00e3o com outros par\u00e2metros hematol\u00f3gicos. M\u00c9TODOS: Foram estudados um total de 65 indiv\u00edduos, divididos em dois grupos: controlos (n = 35) e com doen\u00e7a hep\u00e1tica alco\u00f3lica cr\u00f3nica e trombocitopenia (n = 30). O grupo controlo foi emparelhado por idade e sexo com o grupo de doentes. A todos eles, foi efectuado hemograma completo, incluindo \u00edndices plaquet\u00e1rios. RESULTADOS: Os doentes com doen\u00e7a hep\u00e1tica alco\u00f3lica cr\u00f3nica apresentaram contagem de eritr\u00f3citos, leuc\u00f3citos e plaquetas significativamente inferiores aos encontrados na popula\u00e7\u00e3o controlo. O mesmo se verificou com os valores de hemoglobina, hemat\u00f3crito e valores absolutos de linf\u00f3citos e neutr\u00f3filos. O volume globular m\u00e9dio, a hemoglobina globular m\u00e9dia e o RDW (\"red cell distribution width\") revelaram-se significativamente superiores no grupo de doentes. Relativamente aos \u00edndices plaquet\u00e1rios, foi encontrado aumento estatisticamente significativo do PDW (\"platelet distribution width\") e uma diminui\u00e7\u00e3o estatisticamente significativa no plaquetr\u00f3crito no grupo de doentes quando comparado com o grupo controlo. Em rela\u00e7\u00e3o ao volume plaquet\u00e1rio m\u00e9dio n\u00e3o se encontraram diferen\u00e7as estatisticamente significativas entre os dois grupos. Foi encontrada correla\u00e7\u00e3o estatisticamente significativa entre a contagem de plaquetas e os outros par\u00e2metros hematol\u00f3gicos analisados. O plaquetr\u00f3cito revelou-se o \u00edndice plaquet\u00e1rio que mais se relaciona com os restantes par\u00e2metros hematol\u00f3gicos. CONCLUS\u00c3O: Os doentes com doen\u00e7a hep\u00e1tica alco\u00f3lica cr\u00f3nica apresentam diminui\u00e7\u00e3o nas tr\u00eas linhas hematopoi\u00e9ticas, possivelmente associada com o hiperesplenismo que estes doentes apresentam. Adicionalmente \u00e0s altera\u00e7\u00f5es num\u00e9ricas, encontraram-se altera\u00e7\u00f5es morfol\u00f3gicas a n\u00edvel dos eritr\u00f3citos e plaquetas, demonstr\u00e1veis pelos \u00edndices eritrocit\u00e1rios e plaquet\u00e1rios.<\/jats:p>","DOI":"10.1590\/s0004-28032007000300004","type":"journal-article","created":{"date-parts":[[2007,11,28]],"date-time":"2007-11-28T23:02:18Z","timestamp":1196290938000},"page":"201-204","source":"Crossref","is-referenced-by-count":3,"title":["\u00cdndices plaquet\u00e1rios em indiv\u00edduos com doen\u00e7a hep\u00e1tica alco\u00f3lica cr\u00f4nica"],"prefix":"10.1590","volume":"44","author":[{"given":"Ana Cl\u00e1udia","family":"Costa","sequence":"first","affiliation":[{"name":"Instituto Polit\u00e9cnico de Bragan\u00e7a; Hospital Distrital de Chaves, Portugal"}]},{"given":"Barbara","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Hospital Distrital de Chaves, 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