{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:10:23Z","timestamp":1768518623701,"version":"3.49.0"},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p> Background Inflammatory Bowel Disease is known for its extra intestinal manifestations, the oral cavity is no exception. Objectives The aim of this study was to evaluate the association between Inflammatory Bowel Disease and oral mucosa lesions and symptoms, and complementary to evaluate their possible relation with oral hygiene, smoking habits, drug therapy, duration and activity of the disease. Methods Patients were selected from the Gastroenterology Clinic of a Portuguese tertiary referral hospital. This sample consisted of 113 patients previously diagnosed with ulcerative colitis or Crohn\u2019s disease along with a control group of 58 healthy individuals that were accompanying the study group patients to their appointments. Clinical interviews and clinical examinations were performed for data collection. Results The patients in the study group were more affected by oral symptoms (P=0.011), and showed a trend towards a higher incidence of oral mucosal lesions, even though statistical significance was not reached (8.8% versus 3.4% in the control group; P=0.159). Patients in active phase were the most affected. No differences were detected between Crohn\u2019s disease and ulcerative colitis, or concerning smoking habits. The corticosteroid and immunosuppressant therapy seemed to increase the incidence of oral symptoms (P=0.052). The oral mucosa lesions increased and the oral symptoms decreased over the course of the disease, however without statistical significance. Conclusion Oral mucosa\u2019s lesions and oral symptoms were positively associated with Inflammatory Bowel Disease, mainly during disease activity periods and conceivably, associated with corticosteroid and immunosuppressant therapy.<\/jats:p>","DOI":"10.1590\/s0004-28032015000200006","type":"journal-article","created":{"date-parts":[[2015,5,30]],"date-time":"2015-05-30T18:17:05Z","timestamp":1433009825000},"page":"105-110","source":"Crossref","is-referenced-by-count":31,"title":["ORAL MUCOSA LESIONS AND ORAL SYMPTOMS IN INFLAMMATORY BOWEL DISEASE PATIENTS"],"prefix":"10.1590","volume":"52","author":[{"given":"Nuno","family":"LARANJEIRA","sequence":"first","affiliation":[{"name":"Egas Moniz Health Science Institute,  Portugal"}]},{"given":"Jorge","family":"FONSECA","sequence":"additional","affiliation":[{"name":"Egas Moniz Health Science Institute,  Portugal; Garcia de Orta Hospital,  Portugal"}]},{"given":"T\u00e2nia","family":"MEIRA","sequence":"additional","affiliation":[{"name":"Garcia de Orta Hospital,  Portugal"}]},{"given":"Jo\u00e3o","family":"FREITAS","sequence":"additional","affiliation":[{"name":"Garcia de Orta Hospital,  Portugal"}]},{"given":"Sara","family":"VALIDO","sequence":"additional","affiliation":[{"name":"Egas Moniz Health Science Institute,  Portugal"}]},{"given":"Jorge","family":"LEIT\u00c3O","sequence":"additional","affiliation":[{"name":"Portuguese Catholic University,  Portugal"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"S253","DOI":"10.1016\/S1590-8658(08)60534-4","article-title":"Extraintestinal manifestations of inflammatory bowel disease","volume":"40","author":"Ardizzone S","year":"2008","journal-title":"Dig Liver Dis"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1136\/gut.16.4.249","article-title":"Oral manifestations of Crohn\u2019s disease","volume":"16","author":"Asquith P","year":"1975","journal-title":"Gut"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/S0952-7915(99)00032-1","article-title":"Animal models of mucosal inflammation and their relation to human inflammatory bowel disease","volume":"11","author":"Blumberg RS","year":"1999","journal-title":"Curr Opin Immunol"},{"issue":"4","key":"ref4","first-page":"370","article-title":"Cheilitis","volume":"52","author":"Boisnic S","year":"2002","journal-title":"Rev Prat"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1600-051X.2008.01231.x","article-title":"Prevalence of periodontitis and DMFT index in patients with Crohn\u2019s disease and ulcerative colitis","volume":"35","author":"Brito F","year":"2008","journal-title":"J Clin Periodontol"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1155\/2007\/952673","article-title":"Oral manifestations of gastrointestinal diseases","volume":"21","author":"Daley TD","year":"2007","journal-title":"Can J Gastroenterol"},{"issue":"3","key":"ref7","first-page":"155","article-title":"Association of oral manifestations with ulcerative colitis","volume":"5","author":"Elahi M","year":"2012","journal-title":"Gastroenterol Hepatol Bed Bench"},{"issue":"5","key":"ref8","article-title":"Inflammatory bowel disease","volume":"108","author":"Fatahzadeh M","year":"2009","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 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