{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:17:39Z","timestamp":1761707859560},"reference-count":37,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p>Adenomas clinicamente n\u00e3o-funcionantes de hip\u00f3fise, n\u00e3o produzem cl\u00ednica de hipersecre\u00e7\u00e3o hormonal. Por esse motivo, seus sinais e sintomas dependem de seu efeito de massa no sistema nervoso central. A sua etiopatogenia \u00e9 complexa com v\u00e1rios fatores provavelmente influenciando seu desenvolvimento como os horm\u00f4nios hipotal\u00e2micos (GHRH), fatores de crescimento (FGF), fatores de prolifera\u00e7\u00e3o (PCNA, e KI-67), prote\u00edna P53 e proto-oncogene c-erb-B2. OBJETIVOS: 1) Determinar as caracter\u00edsticas cl\u00ednicas da popula\u00e7\u00e3o de 117 pacientes tratados com adenoma clinicamente n\u00e3o-funcionante de hip\u00f3fise (idade, sexo, tamanho do tumor, n\u00famero de procedimento cir\u00fargico, desenvolvimento de defici\u00eancia hormonal e hiperprolactinemia). 2) Identificar, ap\u00f3s a caracteriza\u00e7\u00e3o cl\u00ednica desses pacientes, aqueles com adenoma clinicamente n\u00e3o-funcionante que apresentam imunoistoqu\u00edmica positiva para os horm\u00f4nios hipofis\u00e1rios PRL LH, FSH, GH, TSH e ACTH. 3) Precisar nessa popula\u00e7\u00e3o a positividade imunoistoqu\u00edmica para o fator de prolifera\u00e7\u00e3o celular Ki-67, para a prote\u00edna P53 e para a prote\u00edna C-erb-B2 correlacionando a sua positividade com o tamanho e invas\u00e3o tumoral. Dessa forma avaliando o valor progn\u00f3stico desses fatores de prolifera\u00e7\u00e3o. 4) Confrontar os resultados da imunoistoqu\u00edmica realizada atrav\u00e9s do bloco padr\u00e3o com os resultados da imunoistoqu\u00edmica obtidos atrav\u00e9s do tissue micro-array. M\u00c9TODO: Estudo das caracter\u00edsticas cl\u00ednicas de 117 pacientes com adenoma clinicamente n\u00e3o-funcionate de hip\u00f3fise (idade, sexo, tamanho do tumor, n\u00famero de procedimento cir\u00fargico, desenvolvimento de defici\u00eancia hormonal e hiperprolactinemia). Estudo imunoistoqu\u00edmico (H&amp;E) de 39 pacientes para horm\u00f4nios hipofis\u00e1rios, para a prote\u00edna P53, prote\u00edna C-erb-B2, Ki-67 e sua correla\u00e7\u00e3o com crescimento tumoral. A seguir, tamb\u00e9m foi realizado o tissue micro-array dos 39 casos, estudados anteriormente, com imunoistoqu\u00edmica para os horm\u00f4nios hipofis\u00e1rios, para a prote\u00edna P 53, prote\u00edna C-erb-B2, Ki-67 e sua correla\u00e7\u00e3o com o crescimento tumoral. RESULTADOS: N\u00e3o houve diferen\u00e7a estatisticamente significante entre os sexos masculino e feminino com rela\u00e7\u00e3o \u00e0 idade, tamanho tumoral e n\u00famero de procedimentos cir\u00fargicos (p=0,279, p=0,813, p=0,139 respectivamente). Existe uma correla\u00e7\u00e3o estatisticamente significativa entre tamanho do tumor, n\u00famero de procedimentos cir\u00fargicos realizados e defici\u00eancia hormonal (p=0,032, p=0,0223 respectivamente). N\u00e3o houve correla\u00e7\u00e3o estatisticamente significativa entre imuno\u00edstoqu\u00edmica positiva para prote\u00edna P53, para a prote\u00edna C-erb-B2, Ki-67 e o tamanho do tumor (r=0,182, p=0,396; r=-0,181, p=0,397; r=0,272, p=0,199, respectivamente) .O tissue micro-array tamb\u00e9m n\u00e3o demonstrou uma correla\u00e7\u00e3o entre a imunoistoqu\u00edmica positiva para Ki-67 e C-erb-B2 e o tamanho do tumor, por\u00e9m mostrou uma correla\u00e7\u00e3o negativa estatisticamente significativa entre a positividade imunoistoqu\u00edmica para p53 e o tamanho do tumor (r=-0,696;p&lt;0,001). CONCLUS\u00c3O: O adenoma clinicamente n\u00e3o-funcionante possui comportamento biol\u00f3gico semelhante em ambos os sexos. Quanto maior o tamanho do tumor maior o n\u00famero de procedimentos cir\u00fargicos necess\u00e1rios e a ocorr\u00eancia de defici\u00eancia hormonal. Esse trabalho sugere que a positividade imunoistoqu\u00edmica para p53 correlaciona negativamente com o tamanho do tumor, demonstrando ter valor progn\u00f3stico. J\u00e1 a imunoistoqu\u00edmica positiva para o Ki-67 a prote\u00edna C-erb-B2 n\u00e3o parece ser um fator progn\u00f3stico nos adenomas de hip\u00f3fise clinicamente n\u00e3o-funcionantes, como s\u00e3o em outros tipos de neoplasias.<\/jats:p>","DOI":"10.1590\/s0004-282x2005000600029","type":"journal-article","created":{"date-parts":[[2006,1,10]],"date-time":"2006-01-10T18:36:52Z","timestamp":1136918212000},"page":"1070-1078","source":"Crossref","is-referenced-by-count":15,"title":["Caracteriza\u00e7\u00e3o cl\u00ednica e imunoistoqu\u00edmica dos adenomas clinicamente n\u00e3o-funcionantes de hip\u00f3fise: clinical features and immunohistochemistry"],"prefix":"10.1590","volume":"63","author":[{"given":"Jane Eyre Alves","family":"Ferreira","sequence":"first","affiliation":[{"name":"Universidade Nacional de Bras\u00edlia Brasilia, Brasil"}]},{"given":"Paulo Andrade de","family":"Mello","sequence":"additional","affiliation":[{"name":"UNB"}]},{"given":"Albino Ver\u00e7osa de","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"UNB"}]},{"given":"Carlos Henrique Aguiar","family":"Botelho","sequence":"additional","affiliation":[{"name":"UNB"}]},{"given":"Luciana Ansaneli","family":"Naves","sequence":"additional","affiliation":[{"name":"Universidade Nacional de Bras\u00edlia Brasilia, Brasil"}]},{"given":"Vania","family":"Nos\u00e9","sequence":"additional","affiliation":[{"name":"Universidade de Harvard, EUA"}]},{"given":"Fernando","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Universidade de Porto, Portugal"}]}],"member":"530","reference":[{"key":"ref1","first-page":"1094","article-title":"Clinically nonfunctional pituitary adenomas","volume":"1089","author":"Katznelson L","year":"1993","journal-title":"J. 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