{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T22:10:53Z","timestamp":1777155053736,"version":"3.51.4"},"reference-count":27,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p>The subcellular events implicated on the formation and behavior of pituitary adenomas are not fully understood. In this study we investigated the presence of p53, Ki-67 and c-erb B2 in 38 pituitary adenomas with immunohistochemical positivity for GH and prolactin (n=26; 68.4%), for prolactin (n=9; 23.7%) and for GH (n=3. 7.8%). The analyses revealed the following results: 24 (63.2%) tumors expressed variable positivity for c-erb B2, 11 (28.9%) expressed p53 positivity and 11 (28.9%) tumors were variably positive for Ki-67. Our results demonstrated a high percentage of GH\/prolactin-, prolactin- and GH-secreting tumors with immunohistochemical positivity for c-erb B2. Once this membrane receptor is related to growth factors EGF and TGFalpha and both have a definite effect on tumor growth, our data suggest a possible role for c-erb B2 on the evolution of these tumors.<\/jats:p>","DOI":"10.1590\/s0004-282x2006000100013","type":"journal-article","created":{"date-parts":[[2006,4,17]],"date-time":"2006-04-17T18:48:52Z","timestamp":1145299732000},"page":"60-66","source":"Crossref","is-referenced-by-count":27,"title":["Expression of p53, Ki-67 and c-erb B2 in growth hormone-and\/or prolactin-secreting pituitary adenomas"],"prefix":"10.1590","volume":"64","author":[{"given":"Carlos Henrique A.","family":"Botelho","sequence":"first","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade do Distrito Federal,  Brazil"}]},{"given":"Albino Ver\u00e7osa de","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia,  Brazil"}]},{"given":"Paulo Andrade de","family":"Mello","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio de Bras\u00edlia,  Brazil"}]},{"given":"Fernando C.","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Medical Faculty of Porto University"}]},{"given":"Luiz Augusto","family":"Casulari","sequence":"additional","affiliation":[{"name":"IPATIMUP,  Portugal"}]}],"member":"530","reference":[{"key":"ref1","series-title":"The pituitary","first-page":"98","volume-title":"Growth hormone","author":"Herman-Bonert VS","year":"1995"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/BF02890257","article-title":"Distribution of growth hormone and prolactin in secretory granules of the normal and neoplastic human adenohypophysis","volume":"53","author":"Zurschmiede C","year":"1987","journal-title":"Virchows Arch B"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1210\/jcem-66-1-24","article-title":"Detection of a potential progenitor 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