{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T14:55:39Z","timestamp":1767192939408},"reference-count":19,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Sa\u00fade P\u00fablica"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p>OBJETIVO: Avaliar os resultados de interven\u00e7\u00e3o para melhoria da quantidade e relev\u00e2ncia das notifica\u00e7\u00f5es de reac\u00e7\u00f5es adversas a medicamentos. M\u00c9TODOS: Foi implementado um estudo controlado aleatorizado, por agrupamentos em farmac\u00eauticos a exercer actividade profissional na regi\u00e3o norte de Portugal, em 2007. Ap\u00f3s aleatoriza\u00e7\u00e3o, 364 indiv\u00edduos foram alocados ao grupo de interven\u00e7\u00e3o (261 na interven\u00e7\u00e3o telef\u00f3nica e 103 nos workshops); o grupo de controlo foi constitu\u00eddo por 1.103 farmac\u00eauticos. Na interven\u00e7\u00e3o educativa foram abordados a problem\u00e1tica das reac\u00e7\u00f5es adversas a medicamentos, o impacto na sa\u00fade p\u00fablica e a notifica\u00e7\u00e3o espont\u00e2nea. Quanto \u00e0 relev\u00e2ncia, as rea\u00e7\u00f5es adversas foram classificadas em graves e inesperadas. A an\u00e1lise estat\u00edstica foi efectuada com base no princ\u00edpio intention-to-treat; aplicaram-se modelos lineares generalizados mistos, utilizando o m\u00e9todo penalized quasi-likelihood. Os farmac\u00eauticos estudados foram seguidos durante um per\u00edodo de 20 meses. RESULTADOS: A interven\u00e7\u00e3o aumentou tr\u00eas vezes a taxa de notifica\u00e7\u00e3o espont\u00e2nea das rea\u00e7\u00f5es adversas (RR = 3,22; IC 95%: 1,33; 7,80) relativamente ao grupo de controlo. Houve incremento da relev\u00e2ncia das notifica\u00e7\u00f5es com aumento das rea\u00e7\u00f5es adversas graves em cerca de quatro vezes (RR = 3,87; IC 95%: 1,29;11,61) e inesperadas em cinco vezes (RR = 5,02; IC 95%: 1,33;18,93), relativamente ao grupo de controlo. CONCLUS\u00d5ES: As interven\u00e7\u00f5es educativas aumentam significativamente, por at\u00e9 quatro meses, a quantidade e a relev\u00e2ncia das notifica\u00e7\u00f5es espont\u00e2neas de reac\u00e7\u00f5es adversas a medicamentos por parte dos farmac\u00eauticos da regi\u00e3o norte de Portugal.<\/jats:p>","DOI":"10.1590\/s0034-89102010005000050","type":"journal-article","created":{"date-parts":[[2010,11,9]],"date-time":"2010-11-09T20:30:44Z","timestamp":1289334644000},"page":"129-135","source":"Crossref","is-referenced-by-count":41,"title":["Estrat\u00e9gias para aumentar a sensibilidade da farmacovigil\u00e2ncia em Portugal"],"prefix":"10.1590","volume":"45","author":[{"given":"In\u00eas","family":"Ribeiro-Vaz","sequence":"first","affiliation":[{"name":"Universidade do Porto,  Portugal"}]},{"given":"Maria Teresa","family":"Herdeiro","sequence":"additional","affiliation":[{"name":"nstituto Polit\u00e9cnico de Sa\u00fade do Norte,  Portugal"}]},{"given":"Jorge","family":"Pol\u00f3nia","sequence":"additional","affiliation":[{"name":"Universidade do Porto,  Portugal"}]},{"given":"Adolfo","family":"Figueiras","sequence":"additional","affiliation":[{"name":"Universidade de Santiago de Compostela,  Espa\u00f1a"}]}],"member":"530","reference":[{"issue":"14","key":"ref1","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.2165\/00002018-200326140-00005","article-title":"Stimulating adverse drug reaction reporting: effect of a drug safety bulletin and of including yellow cards in prescription pads","volume":"26","author":"Castel J","year":"2003","journal-title":"Drug Saf."},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1001\/jama.1995.03530090032018","article-title":"Changing physician performance: A systematic review of the effect of continuing medical education strategies","volume":"274","author":"Davis 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