{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:38:44Z","timestamp":1771493924779,"version":"3.50.1"},"reference-count":33,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. esc. enferm. USP"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>Abstract  OBJECTIVE Determining which is the most effective solution (heparin flush compared to 0.9% saline flush) for reducing the risk of occlusions in central venous catheters (CVC) in adults.  METHOD The systematic review followed the principles proposed by the Cochrane Handbook; critical analysis, extraction and synthesis of data were performed by two independent researchers; statistical analysis was performed using the RevMan program 5.2.8.  RESULTS Eight randomized controlled trials and one cohort study were included and the results of the meta-analysis showed no difference (RR=0.68, 95% CI=0.41-1.10; p=0.12). Analysis by subgroups showed that there was no difference in fully deployed CVC (RR=1.09, CI 95%=0.53-2.22;p=0.82); Multi-Lumen CVC showed beneficial effects in the heparin group (RR=0.53, CI 95%=0.29-0.95; p=0.03); in Double-Lumen CVC for hemodialysis (RR=1.18, CI 95%=0.08-17.82;p=0.90) and Peripherally inserted CVC (RR=0.14, CI 95%=0.01-2.60; p=0.19) also showed no difference.  CONCLUSION Saline solution is sufficient for maintaining patency of the central venous catheter, preventing the risks associated with heparin administration.<\/jats:p>","DOI":"10.1590\/s0080-623420150000600017","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T21:18:43Z","timestamp":1449695923000},"page":"995-1003","source":"Crossref","is-referenced-by-count":16,"title":["Effectiveness of heparin versus 0.9% saline solution in maintaining the permeability of central venous catheters: a systematic review"],"prefix":"10.1590","volume":"49","author":[{"given":"Eduardo Jos\u00e9 Ferreira dos","family":"Santos","sequence":"first","affiliation":[{"name":"Escola Superior de Enfermagem de Coimbra,  Portugal"}]},{"given":"Maria Madalena Jesus Cunha","family":"Nunes","sequence":"additional","affiliation":[{"name":"Instituto Polit\u00e9cnico de Viseu,  Portugal"}]},{"given":"Daniela Filipa Batista","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Escola Superior de Enfermagem de Coimbra,  Portugal"}]},{"given":"Jo\u00e3o Lu\u00eds Alves","family":"Ap\u00f3stolo","sequence":"additional","affiliation":[{"name":"Escola Superior de Enfermagem de Coimbra,  Portugal"}]},{"given":"Paulo Joaquim Pina","family":"Queir\u00f3s","sequence":"additional","affiliation":[{"name":"Escola Superior de Enfermagem de Coimbra,  Portugal"}]},{"given":"Manuel Alves","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Escola Superior de Enfermagem de Coimbra,  Portugal"}]}],"member":"530","reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.12707\/RIII1298","article-title":"Permeabilidade do cateter venoso central: uma revis\u00e3o sistem\u00e1tica da literatura","volume":"serIII","author":"Encarna\u00e7\u00e3o RMC","year":"2013","journal-title":"Rev Enf 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