{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T20:52:48Z","timestamp":1761339168858},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Med. Vet. Zootec."],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p>Values of serum tartrate-resistant acid phosphatase ( TRAP) activity were obtained in adult dogs and its biological variability was assessed. Nine healthy skeletally mature Portuguese Podengo dogs were used for the determination of TRAP, total and bone alkaline phosphatase serum activities, and also to study their relationship with serum minerals, namely calcium (Ca), phosphorous (P), and magnesium (Mg). The serum TRAP activity was 2.19\u00b10.56IU\/mL, with intra-individual variation of 18.3% and inter-individual variation of 25.6%. Significant correlations were observed between serum TRAP activity and Ca (r=-0.3431; P&lt;0.05), Ca and Mg (r=-0.787; P&lt;0.01), and TRAP and Mg (r=0.397; P&lt;0.05). The results indicate that serum TRAP activity in dog could be of great value in research and in clinical practice, providing complementary non-invasive information on bone metabolism<\/jats:p>","DOI":"10.1590\/s0102-09352011000100007","type":"journal-article","created":{"date-parts":[[2011,4,15]],"date-time":"2011-04-15T06:13:49Z","timestamp":1302848029000},"page":"40-45","source":"Crossref","is-referenced-by-count":7,"title":["Tartrate-resistant acid phosphatase as a biomarker of bone turnover in dog"],"prefix":"10.1590","volume":"63","author":[{"given":"C.P","family":"Sousa","sequence":"first","affiliation":[{"name":"UTAD, Portugal; UM, Portugal; PT Gov. Assoc. Lab, Portugal"}]},{"given":"F","family":"Nery","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pathology of Pioledo SA, Portugal"}]},{"given":"J.T","family":"Azevedo","sequence":"additional","affiliation":[{"name":"UTAD, Portugal"}]},{"given":"C.A","family":"Viegas","sequence":"additional","affiliation":[{"name":"UTAD, Portugal; UM, Portugal; PT Gov. Assoc. Lab, Portugal"}]},{"given":"M.E","family":"Gomes","sequence":"additional","affiliation":[{"name":"UM, Portugal; PT Gov. Assoc. Lab, Portugal"}]},{"given":"I.R","family":"Dias","sequence":"additional","affiliation":[{"name":"UTAD, Portugal; UM, Portugal; PT Gov. Assoc. Lab, Portugal"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1053\/rvsc.1999.0369","article-title":"A comparison of two techniques for the determination of serum bone-specific alkaline phosphatase activity in dogs","volume":"68","author":"ALLEN L.C.V","year":"2000","journal-title":"Res. Vet. Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.2460\/ajvr.1998.59.03.250","article-title":"Serum markers of bone metabolism in dogs","volume":"59","author":"ALLEN M","year":"1998","journal-title":"Am. J. Vet. Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1939-165X.2003.tb00323.x","article-title":"Biochemical markers of bone metabolism in animals: uses and limitations","volume":"32","author":"ALLEN M.J","year":"2003","journal-title":"Vet. Clin. Pathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1158\/1078-0432.544.11.2","article-title":"Tartrate-resistant acid phopshatase 5b is a useful serum marker for extensive bone metastasis in breast cancer patients","volume":"11","author":"CHAO T.Y","year":"2005","journal-title":"Clin. Cancer Res","ISSN":"http:\/\/id.crossref.org\/issn\/1078-0432","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1359\/jbmr.1999.14.9.1614","article-title":"Markers of bone turnover predict postmenopausal forearm bone loss over 4 years: the Ofely study","volume":"14","author":"GARNERO P","year":"2002","journal-title":"J. Bone Miner. Res","ISSN":"http:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1359\/JBMR.0301244","article-title":"Biochemical markers of bone metabolism and prediction of fracture in elderly women","volume":"19","author":"GERDHEM P","year":"2004","journal-title":"J. Bone Miner. Res","ISSN":"http:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"key":"ref7","first-page":"1","article-title":"Tartrate-acid phosphatase 5b (TRAP 5b) as a marker of bone resorption","volume":"3","author":"HALLEN J","year":"2006","journal-title":"Immunodiagn. Syst"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s00223-001-2122-7","article-title":"Serum tartrate-acid phosphatase 5b, but not 5a, correlates with other markers of bone turnover and bone mineral density","volume":"71","author":"HALLEN J.M","year":"2002","journal-title":"Calcif. Tissue Int"},{"key":"ref9","first-page":"2263","article-title":"Different kinetics of bone markers in normal and delayed fracture healing of long bones","volume":"48","author":"HERRMANN M","year":"2002","journal-title":"Clin. Chem","ISSN":"http:\/\/id.crossref.org\/issn\/0009-9147","issn-type":"print"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF00571521","article-title":"Types I and III procollagen extension peptides in serum respond to fracture in humans","volume":"111","author":"JOERRING S","year":"1992","journal-title":"Arch. Orthop. Trauma Surg"},{"key":"ref11","series-title":"Clinical biochemistry in domestic animals","author":"KANEKO J.J","year":"2008"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1939-165X.2005.tb00006.x","article-title":"Correlation of serum alkaline phosphatase activity with the healing process of long bone fractures in dogs","volume":"34","author":"KOMNENOU A","year":"2005","journal-title":"Vet. Clin. Pathol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/00005131-200001000-00010","article-title":"Serology of abnormal fracture healing: the role of PIIINP, PICP, and BsALP","volume":"14","author":"KURDY N.M.G","year":"2000","journal-title":"J. Orthop. Trauma"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s00223-001-1026-x","article-title":"Biological variability in serumand urinary indices of bone formation and resorption in dogs","volume":"70","author":"LADLOW J.F","year":"2002","journal-title":"Calcif. Tissue Int"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/PL00002436","article-title":"Sequential changes and pattern of bone-specific alkaline phosphatase after trauma","volume":"26","author":"LAURER H","year":"2000","journal-title":"Eur. J. Trauma"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"214","DOI":"10.17221\/1921-VETMED","article-title":"Tartrate-resistant acid phosphatase, matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in early stages of canine osteoarthritis","volume":"53","author":"LEE H.B","year":"2008","journal-title":"Vet. Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s00228-006-0174-3","article-title":"An update on biomarkers of bone turnover and their utility in biomedical research and clinical practice","volume":"62","author":"LEEMING D.J","year":"2006","journal-title":"Eur. J. Clin. Pharmacol","ISSN":"http:\/\/id.crossref.org\/issn\/0031-6970","issn-type":"print"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1359\/JBMR.050403","article-title":"Serum TRAP 5b is a useful marker for monitoring alendronate tratment: comparison with other markers of bone turnover","volume":"20","author":"NENONEN A","year":"2005","journal-title":"J. Bone Miner. Res","ISSN":"http:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3109\/00365519509110260","article-title":"Biological variation in bone-derived biochemical markers in serum","volume":"55","author":"PANTEGHINI M","year":"1995","journal-title":"Scand. J. Clin. Lab. Invest","ISSN":"http:\/\/id.crossref.org\/issn\/0036-5513","issn-type":"print"},{"key":"ref20","first-page":"46","article-title":"Changes in some serum bone markers after experimental fracture and intramedullary osteosynthesis in dogs","volume":"3","author":"PASKALEV M","year":"1995","journal-title":"Trakia J. Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/BF00298436","article-title":"Serum carboxyterminal telopeptide of type I collagen in an experimental model of canine osteomyelitis","volume":"57","author":"PHILIPOV J.P","year":"1995","journal-title":"Calcif. Tissue Int"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.bone.2005.06.008","article-title":"Do serological tissue markers represent callus formation during fracture healing?","volume":"37","author":"SEEBECK P","year":"2005","journal-title":"Bone","ISSN":"http:\/\/id.crossref.org\/issn\/8756-3282","issn-type":"print"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/j.1365-2265.2007.03112.x","article-title":"The use of molecular markers of bone turnover in the management of patients with metastatic bone disease","volume":"68","author":"SEIBEL M","year":"2008","journal-title":"Clin. Endocrinol","ISSN":"http:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"727","DOI":"10.2460\/ajvr.2003.64.727","article-title":"Evaluation of serum biochemical markers of bone metabolism for early diagnosis of nonunion and infected nonunion fractures in rabbits","volume":"64","author":"SOUTHWOOD L.L","year":"2003","journal-title":"Am. J. Vet. Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.tvjl.2005.02.001","article-title":"The efficacy of the bone markers osteocalcin and the carboxyterminal cross-linked telopeptide of type-I collagen in evaluating osteogenesis in a canine crural lengthening model","volume":"171","author":"THEYSE L","year":"2005","journal-title":"Vet. J"}],"container-title":["Arquivo Brasileiro de Medicina Veterin\u00e1ria e Zootecnia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abmvz\/v63n1\/v63n1a07.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T05:01:03Z","timestamp":1712379663000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-09352011000100007&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0102-09352011000100007"],"URL":"https:\/\/doi.org\/10.1590\/s0102-09352011000100007","relation":{},"ISSN":["0102-0935"],"issn-type":[{"value":"0102-0935","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}