{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T07:50:24Z","timestamp":1649058624414},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>PURPOSE: To investigate whether a third generation colloid, hydroxyethyl starch (HES 130\/0.4), used for perioperative fluid therapy, protects the rat liver against the late-phase response of ischemia\/reperfusion injury (IRI) and if inhibition of neutrophil hepatic infiltration plays a part in this mechanism. METHODS: Wistar rats were used (8 in each group). Three groups had IRI induced by lobar vascular occlusion (60 minutes) and reperfusion (24 hours) and received HES (13 mL\/kg iv), 7.5% saline (HS) (13 mL\/kg iv) or no fluid. Three other groups were sham-operated and received the same fluid as the test groups. After 24 hours of reperfusion, blood was drawn for alanine aminotransferase (ALT) quantification and ischemic liver samples were taken for histological study (hematoxylin and eosin and chloroacetate staining of neutrophils). RESULTS: HES treatment attenuated the elevation in serum ALT (P=0.001) and reduced the extent of hepatocellular necrosis (P&lt;0.01) compared with the IRI controls. HES-mediated cytoprotection was associated with a decrease of infiltration of neutrophils in the necrotic areas (P&lt;0.05) compared with the untreated IRI rats, but not with the volume control IRI rats (P&gt;0.05). CONCLUSION: Hydroxyethyl starch suppresses inflammatory response and ameliorates the late-phase response of hepatic ischemia\/reperfusion injury.<\/jats:p>","DOI":"10.1590\/s0102-86502011000600009","type":"journal-article","created":{"date-parts":[[2011,10,29]],"date-time":"2011-10-29T04:01:22Z","timestamp":1319860882000},"page":"456-462","source":"Crossref","is-referenced-by-count":0,"title":["Protective perioperative strategy using a third generation hydroxyethyl starch during surgery in a murine model of liver reperfusion injury"],"prefix":"10.1590","volume":"26","author":[{"given":"Dora","family":"Catr\u00e9","sequence":"first","affiliation":[{"name":"EPE, Portugal"}]},{"given":"Maria Francelina","family":"Lopes","sequence":"additional","affiliation":[{"name":"University of Coimbra; EPE"}]},{"given":"Celeste","family":"Bento","sequence":"additional","affiliation":[{"name":"EPE"}]},{"given":"Ant\u00f3nio Silv\u00e9rio","family":"Cabrita","sequence":"additional","affiliation":[{"name":"University of Coimbra"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0014-4800(03)00008-X","article-title":"Hepatic ischemia\/reperfusion injury - a fresh look","volume":"74","author":"Fondevila C","year":"2003","journal-title":"Exp Mol Pathol."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"G1083","DOI":"10.1152\/ajpgi.00568.2005","article-title":"Mechanisms of liver injury: II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions","volume":"290","author":"Jaeschke H.","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2147\/IJGM.S3495","article-title":"Update on transfusion solutions during surgery: review of hydroxyethyl starches 130\/0.4","volume":"3","author":"Piazza O","year":"2010","journal-title":"Int J Gen Med."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1097\/00000539-200104000-00011","article-title":"Voluven, a lower substituted novel hydroxyethyl starch (HES 130\/0.4), causes fewer effects on coagulation in major orthopedic surgery than HES 200\/0.5","volume":"92","author":"Langeron O","year":"2001","journal-title":"Anesth Analg."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1017\/S026502150800447X","article-title":"Safety of HES 130\/0.4 (Voluven(R) in patients with preoperative renal dysfunction undergoing abdominal aortic surgery: a prospective, randomized, controlled, parallel-group multicentre trial","volume":"25","author":"Godet G","year":"2008","journal-title":"Eur J Anaesthesiol."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1161\/01.STR.31.9.2218","article-title":"Hydroxyethyl starch reduces leukocyte adherence and vascular injury in the newborn pig cerebral circulation after asphyxia","volume":"31","author":"Kaplan SS","year":"2000","journal-title":"Stroke","ISSN":"http:\/\/id.crossref.org\/issn\/0039-2499","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00003643-200404000-00010","article-title":"Differential platelet receptor expression following hydroxyethyl starch infusion in thrombocytopaenic orthotopic liver transplantation recipients","volume":"21","author":"J\u00fcttner B","year":"2004","journal-title":"Eur J Anaesthesiol."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/BF03018364","article-title":"Volume replacement with HES 130\/0.4 may reduce the inflammatory response in patients undergoing major abdominal surgery","volume":"50","author":"Lang K","year":"2003","journal-title":"Can J Anaesth."},{"key":"ref9","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0002-9440(10)64214-9","article-title":"Ischemic preconditioning increases the tolerance of Fatty liver to hepatic ischemia-reperfusion injury in the rat","volume":"161","author":"Seraf\u00edn A","year":"2002","journal-title":"Am J Pathol."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"G760","DOI":"10.1152\/ajpgi.00141.2005","article-title":"Generation of hypochlorite-modified proteins by neutrophils during ischemia-reperfusion injury in rat liver: attenuation by ischemic preconditioning","volume":"289","author":"Hasegawa T","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"ref11","first-page":"248","article-title":"Dextran vs. hydroxyethylstarch in inhibition of postischemic leukocyte adherence in striated muscle","volume":"41","author":"Menger MD","year":"1993","journal-title":"Circ Shock."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1097\/00003246-198912000-00012","article-title":"Macromolecules reduce abnormal microvascular permeability in rat limb ischemia\/reperfusion injury","volume":"17","author":"Zikria BA","year":"1989","journal-title":"Crit Care Med."},{"key":"ref13","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/01.shk.0000180625.53800.63","article-title":"Hydroxyethyl starch inhibits neutrophil adhesion and transendothelial migration","volume":"24","author":"Handrigan MT","year":"2005","journal-title":"Shock","ISSN":"http:\/\/id.crossref.org\/issn\/1073-2322","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s12630-010-9282-8","article-title":"Hydroxyethyl starch 130\/0.4 attenuates early hepatic damage in ischemia\/reperfusion injury","volume":"57","author":"Catr\u00e9 D","year":"2010","journal-title":"Can J Anaesth."},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1152\/physrev.00027.2008","article-title":"The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair","volume":"89","author":"Vollmar B","year":"2009","journal-title":"Physiol Rev."}],"container-title":["Acta Cirurgica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/acb\/v26n6\/09.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T19:52:26Z","timestamp":1560887546000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502011000600009&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0102-86502011000600009"],"URL":"https:\/\/doi.org\/10.1590\/s0102-86502011000600009","relation":{},"ISSN":["0102-8650"],"issn-type":[{"value":"0102-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}