{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T21:06:22Z","timestamp":1648847182500},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. paul. pediatr."],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>OBJETIVO: Descrever as caracter\u00edsticas cl\u00ednicas e a letalidade, al\u00e9m de analisar os fatores progn\u00f3sticos da infec\u00e7\u00e3o pela influenza pand\u00eamica A (H1N1), em crian\u00e7as do estado do Paran\u00e1. M\u00c9TODOS: Estudo observacional e retrospectivo. Os dados foram coletados a partir do Sistema Nacional de Agravos de Notifica\u00e7\u00e3o (Sinan), do Minist\u00e9rio da Sa\u00fade, entre mar\u00e7o e dezembro de 2010. Foram inclu\u00eddas as crian\u00e7as com idade entre zero e 12 anos, com confirma\u00e7\u00e3o laboratorial da infec\u00e7\u00e3o. As vari\u00e1veis referentes \u00e0s caracter\u00edsticas demogr\u00e1ficas e cl\u00ednicas e aos desfechos foram avaliadas estatisticamente a fim de comparar as taxas de letalidade na presen\u00e7a e na aus\u00eancia desses fatores. Os fatores progn\u00f3sticos foram identificados por regress\u00e3o log\u00edstica. Consideraram-se como significativos os valores de p&lt;0,05. RESULTADOS: Foram inclu\u00eddas 1.307 crian\u00e7as, das quais 19 foram a \u00f3bito. Os fatores de risco para o \u00f3bito foram cardiopatias (OR 7,1; IC95% 1,5 - 32,7), imunodepress\u00e3o (OR 14,9; IC95% 3,9 - 56,2), dispneia (OR 9,5; IC95% 2,8 - 32,9), pneumonia (OR 23,8; IC95% 2,4 - 239,8), presen\u00e7a de sibilos (OR 11,9; IC95% 1,4 - 103,7) e tempo para o in\u00edcio do tratamento a partir do in\u00edcio dos sintomas (OR 1,3; IC95% 1,2 - 1,5). O tratamento precoce com o antiviral oseltamivir foi um fator de prote\u00e7\u00e3o ao \u00f3bito (OR 0,012; IC95% 0,003 - 0,05). CONCLUS\u00d5ES: Os fatores de risco subjacentes apresentaram papel fundamental na determina\u00e7\u00e3o dos desfechos. O diagn\u00f3stico e o tratamento precoce foram importantes para a diminui\u00e7\u00e3o dos \u00f3bitos pela influenza A (H1N1) 2009 em crian\u00e7as.<\/jats:p>","DOI":"10.1590\/s0103-05822012000300007","type":"journal-article","created":{"date-parts":[[2012,10,31]],"date-time":"2012-10-31T14:21:09Z","timestamp":1351693269000},"page":"346-352","source":"Crossref","is-referenced-by-count":10,"title":["Manifesta\u00e7\u00f5es cl\u00ednicas, desfechos e fatores progn\u00f3sticos da influenza pand\u00eamica A (H1N1) de 2009 em crian\u00e7as"],"prefix":"10.1590","volume":"30","author":[{"given":"Luana","family":"Lenzi","sequence":"first","affiliation":[]},{"given":"\u00c2ngela Maron de","family":"Mello","sequence":"additional","affiliation":[{"name":"Secretaria Estadual de Sa\u00fade, Brasil"}]},{"given":"Lineu Roberto da","family":"Silva","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade, Brasil"}]},{"given":"M\u00f4nica Holtz 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