{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:18:59Z","timestamp":1753888739877,"version":"3.41.2"},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Saude soc."],"abstract":"<jats:p>Abstract Geographical variation on hip fractures (HF) may be related to the geographical variation of drinking water composition (DWC); minerals in drinking water may contribute to its fragility. We aim to investigate the effects of DWC on HF risk in Portugal (2000-2010). From National Hospital Discharge Register we selected admissions of patients aged \u226550 years, diagnosed with HF caused by low\/moderate energy traumas. Water components and characteristics were selected at the municipality level. A spatial generalized additive model with a negative binomial distribution as a link function was used to estimate the association of HF with variations in DWC. There were 96,905HF (77.3% in women). The spatial pattern of HF risk was attenuated after being adjusted for water parameters. Results show an indirect association between calcium, magnesium, and iron and HF risk but no clear relation between aluminum, cadmium, fluoride, manganese, or color and HF risk. Regarding pH, the 6.7pH and 7pH interval seems to pose a lower risk. Different dose-response relationships were identified. The increase of calcium, magnesium, and iron values in DWC seems to reduce regional HF risk. Long-term exposure to water parameters, even within the regulatory limits, might increase the regional HF risk.<\/jats:p>","DOI":"10.1590\/s0104-12902020200094","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T20:09:40Z","timestamp":1603138180000},"source":"Crossref","is-referenced-by-count":0,"title":["Regional drinking water composition effects on hip fracture risk: a spatial analysis of nationwide hospital admissions in Portugal, from 2000 to 2010"],"prefix":"10.1590","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4594-1723","authenticated-orcid":false,"given":"Carla Maria","family":"Oliveira","sequence":"first","affiliation":[{"name":"Universidade do Porto,  Portugal; Universidade do Porto,  Portugal; Instituto Polit\u00e9cnico do Porto,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8283-5826","authenticated-orcid":false,"given":"Hugo","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Universidade do Porto,  Portugal; Universidade do Porto,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2318-7491","authenticated-orcid":false,"given":"Sandra Maria","family":"Alves","sequence":"additional","affiliation":[{"name":"Universidade do Porto,  Portugal; Universidade do Porto,  Portugal; Instituto Polit\u00e9cnico do Porto,  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1521-7865","authenticated-orcid":false,"given":"Maria F\u00e1tima","family":"Pina","sequence":"additional","affiliation":[{"name":"Universidade do Porto,  Portugal; Universidade do Porto,  Portugal; Funda\u00e7\u00e3o Oswaldo Cruz,  Brasil"}]}],"member":"530","published-online":{"date-parts":[[2020]]},"reference":[{"issue":"2-3","key":"ref1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jtemb.2012.03.017","article-title":"Osteoporosis and trace elements--an overview","volume":"26","author":"AASETH J.","year":"2012","journal-title":"Journal of Trace Elements in Medicine and Biology"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3109\/17453678008990817","article-title":"The effect of drinking water fluoridation on the fluoride content, strength and mineral density of human bone","volume":"51","author":"ALHAVA E. 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